Pyrantel Pamoate Pharmacology

Pyrantel Pamoate

About Pyrantel Pamoate
A depolarizing neuromuscular blocking agent, Anthelmintic, antinematodal.
Mechanism of Action of Pyrantel Pamoate
It is a pyramidine derivative used as an anthelminthic agent. It acts by producing paralysis in worms by causing activation of nicotinic cholinergic receptors in the worms which leads to persistent depolarization & slowly developing contracture and spastic paralysis. The paralyzed worms are expelled out. The drug also posses anticholisterase action.

Pharmacokinets of Pyrantel Pamoate
Absorption: Poorly absorbed orally, Metabolism: It is partially metabolized in liver, Excretion: Excreted mainly through urine and a small portion is excreted through urine.
Onset of Action for Pyrantel Pamoate
N/A
Duration of Action for Pyrantel Pamoate
N/A
Half Life of Pyrantel Pamoate
N/A
Side Effects of Pyrantel Pamoate
1. Headache
2. Dizziness
3. Insomnia
4. Nausea
5. Vomiting
6. Gastro intestinal disturbances
7. Rashes
8. Transient elevation of liver enzymes.
Contra-indications of Pyrantel Pamoate
1.Along with piperazine
2.Hepatic impairment
3.Hypersensitivity to the drug
Special Precautions while taking Pyrantel Pamoate
1.Anaemic and malnourished individuals
Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Children (Above 2 years) May be used
Neonates & Children below 2 years: Contraindicated
Indications for Pyrantel Pamoate
1.Pinworm infections
2.Round worm infections
3.Hook worm infections
4.Strongyloides infection
5.Trichinosis
6.Necatoriasis


Interactions for Pyrantel Pamoate
Piperazine: In ascariasis, pyrantel and piperazine are mutually antagonistic.
Theophylline: Serum levels of theophlline may be increased.

Typical Dosage for Pyrantel Pamoate
11mg/kg body weight. Maximum: 1g in a single oral dose.
In heavy hookworm infestation give for two successive days.

Schedule of Pyrantel Pamoate
H
Storage Requirements for Pyrantel Pamoate
Store in a well closed container and protect from light
Effects of Missed Dosage of Pyrantel Pamoate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Pyrantel Pamoate
Treatment is supportive & symptomatic. Empty stomach by induced emesis & gastric lavage; within 4 hours after ingestion. Give activated charcoal to reduce absorption.

Home Delivery for Pyrantel Pamoate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pyrantel pamoate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pyrantel pamoate and other medicines and health products. Home delivery services for pyrantel pamoate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pyrantel pamoate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pyrantel pamoate before they complete the sale. You can get this information while placing the order for pyrantel pamoate with the pharmacy.

Pyrantel Pamoate is a generic medicine name and there are several brands available for it. Some of the brands for pyrantel pamoate might be better known than pyrantel pamoate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pyrantel pamoate in stock, you can ask for one of the branded alternatives for pyrantel pamoate.