Lopinavir Pharmacology

Lopinavir

About Lopinavir
Protease Inhibitor, Antiretroviral.
Mechanism of Action of Lopinavir
Lopinavir is a peptide analogue. It reversibly binds to the catalytic site of HIV encoded aspartyl protease enzyme which is involved in the degradation of poly protein into structural protein and subsequent maturation of virus particle. Binding of Lopinavir to the enzyme results in immature noninfectious viral progeny
Pharmacokinets of Lopinavir
Absorption: It is orally absorbed
Distribution: It is distributed mainly in protein bound form
Metabolism: It undergoes metabolism in the liver.
Excretion: Drug and its metabolites are excreted mainly in faeces.
Onset of Action for Lopinavir
N/A
Duration of Action for Lopinavir
N/A
Half Life of Lopinavir
5 to 6 hours
Side Effects of Lopinavir
1.Diarrhoea
2.Nausea
3.Abdominal pain
4.Asthenia
5.Headache
6.Vomiting
7.Stomach pain
8.Unusual bleeding
9.Extreme tiredness
10.Loss of appetite
11.Flu-like symptoms
12.Thirst
13.Dry mouth
14.Tiredness
15.Flushing
16.Dry skin
17.Frequent urination
Contra-indications of Lopinavir
Hypersensitivity to Lopinavir
Special Precautions while taking Lopinavir
1.Hepatic impairment
2.Renal impairment
3.Cardiac impairment
4.Diabetes Mellitus
5.Hemophilia
6.Pancreatitis
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Lopinavir
1. HIV infection
Interactions for Lopinavir
N/A
Typical Dosage for Lopinavir
Adult: 800mg/ day in 2 divided doses
Schedule of Lopinavir
N/A
Storage Requirements for Lopinavir
Store at room temperature. Keep away from heat, light and moisture.
Effects of Missed Dosage of Lopinavir
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Lopinavir
Give supportive measures and symptomatic treatment.

Home Delivery for Lopinavir in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lopinavir.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lopinavir and other medicines and health products. Home delivery services for lopinavir may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lopinavir only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lopinavir before they complete the sale. You can get this information while placing the order for lopinavir with the pharmacy.

Lopinavir is a generic medicine name and there are several brands available for it. Some of the brands for lopinavir might be better known than lopinavir itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lopinavir in stock, you can ask for one of the branded alternatives for lopinavir.