Indinavir Pharmacology

Indinavir

About Indinavir

Protease Inhibitor , Antiretroviral Agent.

Mechanism of Action of Indinavir

Indinavir is a peptide analogue. It reversibly binds to the HIV encoded aspartyl protease enzyme which is involved in the degradation of poly protein into structural protein and subsequent maturation of virus particle. Binding of Indinavir to the enzyme results in immature noninfectious viral progeny

Pharmacokinets of Indinavir

Absorption: It is rapidly absorbed after oral administration. Distribution: About half of the drug is distributed as protein bound form. Metabolism: It undergoes metabolism in the liver. Excretion: The metabolites are excreted through faeces and the parent drug through urine.

Onset of Action for Indinavir

60 minute

Duration of Action for Indinavir

N/A

Half Life of Indinavir

90 - 120 minute

Side Effects of Indinavir

1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal pain
5. Crystalluria
6. Nephrolithiasis
7. Headache
8. Dizziness
9. Hyperpigmentation
10. Anaemia
11. Hyperbilirubinaemia

Contra-indications of Indinavir

Hypersensitivity to Indinavir

Special Precautions while taking Indinavir

1.Renal impairment
2.Hepatic dysfunction

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated
NEONATES: contraindicated

Indications for Indinavir

HIV infection

Interactions for Indinavir

HMG-CoA reductase inhibitors: Risk of myopathy including rhabdomyolysis.
Rifampin: AUC of indinavir decreased by 89%?9%.
Rifabutin: Efficacy of indinavir reduced.
Ketoconazole: Efficacy of indinavir enhanced.
Grapefruit Juice: Efficacy of indinavir decreased.
Nevirapine: Efficacy of indinavir decreased.

Typical Dosage for Indinavir

Adult: 2.4 g / day in 3 equal divided dose; given along with other antiretroviral drugs

Schedule of Indinavir

Storage Requirements for Indinavir

Store at 15 - 30 degree C.Protect away from heat and light. Keep out of the reach of children

Effects of Missed Dosage of Indinavir

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose

Effects of Overdose of Indinavir

Give supportive measures and treatment

Home Delivery for Indinavir in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including indinavir.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for indinavir and other medicines and health products. Home delivery services for indinavir may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take indinavir only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for indinavir before they complete the sale. You can get this information while placing the order for indinavir with the pharmacy.

Indinavir is a generic medicine name and there are several brands available for it. Some of the brands for indinavir might be better known than indinavir itself. If the pharmacy that's willing to deliver medicines to your home doesn't have indinavir in stock, you can ask for one of the branded alternatives for indinavir.