Hydroxychloroquine sulphate Pharmacology

Hydroxychloroquine sulphate

About Hydroxychloroquine sulphate
Aminoquinolone derivative, Antimalarial, antirheumatic.
Mechanism of Action of Hydroxychloroquine sulphate
Malarial parasites digest their own haemoglobin and release highly toxic heme.But this haeme is used up by parasitic polymerase enzyme and converted to non toxic haemozoin.Since Hydroxychloroquine is a weak base it has high affinity towards acidic lysosome.Hydroxychloroquine inhibits polymerase enzyme and interfere the formation of haemozoin and results in accumulation of toxic haeme and haeme - Hydroxychloroquine complex. Formations of these lead to membrane lysis and kill the parasite. Hydroxychloroquine binds to DNA and inhibits protein synthesis.
Anti-inflammatory action: Hydroxychloroquine antagonizes the inflammatory mediators such as histamine and serotonin. It also inhibits the conversion of arachidonic acid to prostaglandin F2 and also inhibits the chemotaxis of polymorphonuclear leukocytes, macrophages and eosinophils.
Pharmacokinets of Hydroxychloroquine sulphate
Absorption: It is well absorbed after oral administration. Distribution: It is distributed in protein bound form and concentrated in melanin containing cells. Metabolism: some drugs undergo metabolism in the liver. Excretion: It is excreted mainly through urine.
Onset of Action for Hydroxychloroquine sulphate
N/A
Duration of Action for Hydroxychloroquine sulphate
N/A
Half Life of Hydroxychloroquine sulphate
N/A
Side Effects of Hydroxychloroquine sulphate
1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal cramps
5.Nystagmus
6.Retinal changes
7.Dizziness
8.Aplastic anaemia
9. Pruritis
10.Headache
11.Ototoxicity
Contra-indications of Hydroxychloroquine sulphate
1.Hypersensitivity to Hydroxychloroquine and other 4- Amino quinolines,
2.Porphyria,
3.Retinal damage
Special Precautions while taking Hydroxychloroquine sulphate
1.Hepatic dysfunction
2.Renal impairment
3.Epilepsy
4.Patients with G -6-PD deficiency
5.Preexisting retinal damage
6.Hematological disorder
7.Gastrointestinal disorder
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Hydroxychloroquine sulphate
1.Malaria
2.Rheumatoid arthritis
3.Discoid Lupus Erythematosus
Interactions for Hydroxychloroquine sulphate
N/A
Typical Dosage for Hydroxychloroquine sulphate
Adult: Malarial prophylaxis: 310 mg base (400 mg sulphate) once in 7 days
Acute attack of Malaria: Initial dose: 620 mg base (800 mg sulphate);after 6 hours
400 mg (310 mg base); third and forth dose (310 mg base) is administered after 24 and 48 hours of initial dose:
Rheumatoid arthritis: 400 - 600 mg once daily for 1 - 3 month and then dose can be reduced to half.
Systemic and Chronic Discoid Lupus Erythematosus: 400mg once or twice daily.
Maintenance dose: 200 - 400 mg daily
Children: : Malarial prophylaxis: 5mg base /kg body weight / day once in 7 days
Acute attack of Malaria:
Initial dose: 10mg base /kg body weight; after 6 hours 5mg base /kg body weight; third and forth dose (5mg base/kg body weight) is administered after 24 and 48 hours of initial dose.
Schedule of Hydroxychloroquine sulphate
H
Storage Requirements for Hydroxychloroquine sulphate
The drug should be stored in cool dark place. Protect away from sun light. Keep out of the reach of children.
Effects of Missed Dosage of Hydroxychloroquine sulphate
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Hydroxychloroquine sulphate
Give supportive measures and treatment. Induce emesis or gastric lavage has to be done followed by administration of charcoal. To control seizure Thiopentone can be given to the patient. Peritoneal dialysis may be used in emergency conditions.

Home Delivery for Hydroxychloroquine sulphate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including hydroxychloroquine sulphate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydroxychloroquine sulphate and other medicines and health products. Home delivery services for hydroxychloroquine sulphate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hydroxychloroquine sulphate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydroxychloroquine sulphate before they complete the sale. You can get this information while placing the order for hydroxychloroquine sulphate with the pharmacy.

Hydroxychloroquine sulphate is a generic medicine name and there are several brands available for it. Some of the brands for hydroxychloroquine sulphate might be better known than hydroxychloroquine sulphate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroxychloroquine sulphate in stock, you can ask for one of the branded alternatives for hydroxychloroquine sulphate.