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- Pharmacology For Ornidazole + Norfloxacin
Ornidazole + Norfloxacin Pharmacology
Ornidazole + Norfloxacin
About Ornidazole + NorfloxacinN/AMechanism of Action of Ornidazole + NorfloxacinN/APharmacokinets of Ornidazole + NorfloxacinN/AOnset of Action for Ornidazole + NorfloxacinN/ADuration of Action for Ornidazole + NorfloxacinN/AHalf Life of Ornidazole + NorfloxacinN/ASide Effects of Ornidazole + NorfloxacinN/AContra-indications of Ornidazole + NorfloxacinN/ASpecial Precautions while taking Ornidazole + NorfloxacinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ornidazole + NorfloxacinN/AInteractions for Ornidazole + NorfloxacinN/ATypical Dosage for Ornidazole + NorfloxacinN/ASchedule of Ornidazole + NorfloxacinN/AStorage Requirements for Ornidazole + NorfloxacinN/AEffects of Missed Dosage of Ornidazole + NorfloxacinN/AEffects of Overdose of Ornidazole + NorfloxacinN/AOrnidazole
About OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. Norfloxacin
About NorfloxacinA synthetic second generation synthetic fluoroquinolone (quinolone), Broad spectrum Antibiotic.Mechanism of Action of NorfloxacinNorfloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Norfloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of NorfloxacinAbsorption: About 30 - 40 % of the drug is absorbed after oral administration.
Distribution: It is distributed in the body.
Metabolism: It undergoes hepatic metabolism.
Excretion: Drug is excreted mainly through urine and also through faeces.
Onset of Action for Norfloxacin0.5 - 1 hoursDuration of Action for Norfloxacin8 - 12 hoursHalf Life of Norfloxacin3 - 4 hoursSide Effects of Norfloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Seizure
6. Dizziness
7. Depression
8. Headache
9. Rash
10. Confusion
11. Insomnia
12. Anorexia
13. Pruritis
14. Photosensitivity
Contra-indications of Norfloxacin1. Hypersensitivity to Norfloxacin and other FluoroquinolonesSpecial Precautions while taking Norfloxacin1. Hepatic impairment
2. Renal impairment
3. Epilepsy
4. Dehydration
5. Caution while driving the vehicle or operating machine or involved in any hazardous activities
6. Avoid exposure to sunlight.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: Contraindicated
Indications for Norfloxacin1. Urinary tract infection
2. Gonorrhoea
3. Typhoid fever
4. Gastroenteritis
5. Prostatitis
6. Traveler`s diarrhoea
Interactions for NorfloxacinAntineoplastic drugs: Decrease serum levels of norfloxacin.
Caffeine: Enhanced efficacy of caffeine.
Oral anticoagulants: Enhanced effects of anticoagulants.
Cyclosporine: Nephrotoxicity increased by norfloxacin.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.Typical Dosage for NorfloxacinAdults: 400 mg twice daily.
UTI: 800 mg / day in 2 divided doses for 3 - 21 days; Dose is determined on the basis of severity of the infection, type of infecting organism
Typhoid fever: 800 mg / day in 2 divided doses for 2 weeks.
Gonorrhoea: 800 mg / day as a single dose
Prostatitis: 800 mg / day in 2 divided doses for 4 weeks
Gastroenteritis: 800 mg / day in 2 divided doses for 5 days.
Traveler`s diarrhoea: 800 mg / day in 2 divided doses for up to 3 days
Schedule of NorfloxacinHStorage Requirements for NorfloxacinStore at 15 - 30 degree C in a tightly closed containerEffects of Missed Dosage of NorfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of NorfloxacinGive supportive measures and symptomatic treatment. Home Delivery for Ornidazole + Norfloxacin in Your City
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Please be aware that you should take ornidazole + norfloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ornidazole + norfloxacin before they complete the sale. You can get this information while placing the order for ornidazole + norfloxacin with the pharmacy.
Ornidazole + Norfloxacin is a generic medicine name and there are several brands available for it. Some of the brands for ornidazole + norfloxacin might be better known than ornidazole + norfloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ornidazole + norfloxacin in stock, you can ask for one of the branded alternatives for ornidazole + norfloxacin.