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- Pharmacology For Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
Tinidazole + Diloxanide Furoate + Methyl Polysiloxane Pharmacology
Tinidazole + Diloxanide Furoate + Methyl Polysiloxane
About Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AMechanism of Action of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/APharmacokinets of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AOnset of Action for Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/ADuration of Action for Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AHalf Life of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/ASide Effects of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AContra-indications of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/ASpecial Precautions while taking Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AInteractions for Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/ATypical Dosage for Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/ASchedule of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AStorage Requirements for Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AEffects of Missed Dosage of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/AEffects of Overdose of Tinidazole + Diloxanide Furoate + Methyl PolysiloxaneN/ATinidazole
About TinidazoleNitroimidazole antibiotic, Antibacterial, antiprotozoal.Mechanism of Action of TinidazoleTinidazole is nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. .DNA helix destabilization &strand breakage has been observed.Pharmacokinets of TinidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by oxidation &glucuronide conjugation, Excretion: Excreted in urine.
Onset of Action for TinidazoleWithin few hoursDuration of Action for Tinidazole16 hoursHalf Life of Tinidazole12 hoursSide Effects of Tinidazole1.Anorexia
2.Bitter taste
3.Nausea
4.Vomiting
5.Diarrhoea
6.Fatigue
7.Dry mouth
8.Abdominal distress
9.Headache
10.Dizziness
11.Vertigo
12.Rash
13.Urticaria
14.Angioedema
15.Peripheral neuropathy & CNS effects,
Contra-indications of Tinidazole1.Hypersensitivity to the drug
2.Blood dyscrasias
3.CNS disorders
Special Precautions while taking Tinidazole1.Hepatic impairment
2.Alcoholic cirrhosis
3.Obstructive liver diseases
4. Use cautiously along with other hepatotoxic drugs & In visual field changes
5. Avoid alcohol use during therapy
Pregnancy Related InformationUse with caution, but contra indicated in first trimesterOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Tinidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Prophylactic agent after colorectal surgery
6.H. pylori infections
Interactions for TinidazoleAlcohol: Disulfiram like reaction.
Ampicillin, Doxycycline and Cotrimoxaole: Synergism with these agents.Typical Dosage for TinidazoleAmoebiasis:
Adults: 2gm once daily for 3 days
Children: 30 to 50mg/kg/day or 600mg 12hourly for 5 to 10 days
Trichomoniasis & Giardiasis:
600mg once daily for a week or 2gm single dose
Anaerobic bacterial infections:
2 gm followed by 500mg 12 hourly for 5 days
Prophylaxis after colorectal surgery:
2gm single dose before surgery
H. pylori infections:
0.5gm 12hourly for 7 to14 days in triple combination
Schedule of TinidazoleHStorage Requirements for TinidazoleStore at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.Effects of Missed Dosage of TinidazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TinidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. For controlling seizures diazepam & phenytoin may be used Diloxanide Furoate
About Diloxanide FuroateDichloroacetamide derivative, anti-protozoal, Luminal amebicides.Mechanism of Action of Diloxanide FuroateDiloxanide Furoate is a dicloroacetamide derivative which acts as a luminal amoebicide. It exerts its action by directly killing the trophozoites responsible for production of cysts.Pharmacokinets of Diloxanide FuroateAbsorption: Orally well absorbed.
Metabolism: It is metabolized by glucuronide conjugation.
Excretion: Excreted through urine.
Onset of Action for Diloxanide FuroateN/ADuration of Action for Diloxanide FuroateN/AHalf Life of Diloxanide FuroateN/ASide Effects of Diloxanide Furoate1. Flatulence
2. Nausea
3. Itching
4. Urticaria rashes
Contra-indications of Diloxanide FuroateN/ASpecial Precautions while taking Diloxanide Furoate1. Hepatic impairmentPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 2 years : ContraindicatedIndications for Diloxanide Furoate1. Mild intestinal Amoebiasis,
2. Asymptomatic cyst passers of Entamoeba histolitica
Interactions for Diloxanide FuroateNo known interaction.Typical Dosage for Diloxanide FuroateAdults: 0.5gm 8hourly for 5 to 10days.
Children (above 2years): 20mg/kg/day in divided doses up to 10days.
Schedule of Diloxanide FuroateHStorage Requirements for Diloxanide FuroateStore in a cool dry place.Protect from heat and light.Keep out of the reach of children.Effects of Missed Dosage of Diloxanide FuroateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diloxanide FuroateGive supportive measures and symptomatic treatment.Methyl Polysiloxane
About Methyl PolysiloxaneSiloxanes, Antiflatulent.Mechanism of Action of Methyl PolysiloxaneMethyl Polysiloxane relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas.Pharmacokinets of Methyl PolysiloxaneN/AOnset of Action for Methyl PolysiloxaneN/ADuration of Action for Methyl PolysiloxaneN/AHalf Life of Methyl PolysiloxaneN/ASide Effects of Methyl PolysiloxaneN/AContra-indications of Methyl PolysiloxaneHypersensitivity to Methyl PolysiloxaneSpecial Precautions while taking Methyl PolysiloxaneKidney failurePregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Methyl Polysiloxane1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Methyl PolysiloxaneN/ATypical Dosage for Methyl Polysiloxane125 - 166 mg taken half an hour before food.
Methyl Polysiloxane in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Methyl Polysiloxane
Schedule of Methyl PolysiloxaneN/AStorage Requirements for Methyl PolysiloxaneStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of Methyl PolysiloxaneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Methyl PolysiloxaneGive symptomatic and supportive treatment.Home Delivery for Tinidazole + Diloxanide Furoate + Methyl Polysiloxane in Your City
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