- Medicine India
- Generic Medicines
- F
- Pharmacology For Fluconazole + Secnidazole + Azithromycin
Fluconazole + Secnidazole + Azithromycin Pharmacology
Fluconazole + Secnidazole + Azithromycin
About Fluconazole + Secnidazole + AzithromycinN/AMechanism of Action of Fluconazole + Secnidazole + AzithromycinN/APharmacokinets of Fluconazole + Secnidazole + AzithromycinN/AOnset of Action for Fluconazole + Secnidazole + AzithromycinN/ADuration of Action for Fluconazole + Secnidazole + AzithromycinN/AHalf Life of Fluconazole + Secnidazole + AzithromycinN/ASide Effects of Fluconazole + Secnidazole + AzithromycinN/AContra-indications of Fluconazole + Secnidazole + AzithromycinN/ASpecial Precautions while taking Fluconazole + Secnidazole + AzithromycinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Fluconazole + Secnidazole + AzithromycinN/AInteractions for Fluconazole + Secnidazole + AzithromycinN/ATypical Dosage for Fluconazole + Secnidazole + AzithromycinN/ASchedule of Fluconazole + Secnidazole + AzithromycinN/AStorage Requirements for Fluconazole + Secnidazole + AzithromycinN/AEffects of Missed Dosage of Fluconazole + Secnidazole + AzithromycinN/AEffects of Overdose of Fluconazole + Secnidazole + AzithromycinN/AFluconazole
About FluconazoleA triazole derivative, A board range Antifungal.Mechanism of Action of FluconazoleFluconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesisPharmacokinets of FluconazoleAbsorption: It is well absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes insignificant metabolism. Excretion: It is excreted mainly through urine.Onset of Action for FluconazoleN/ADuration of Action for Fluconazole1 dayHalf Life of FluconazoleN/ASide Effects of Fluconazole1.Abdominal pain
2.Nausea
3.Vomiting
4.Diarrhoea
5.Alopecia
6.Headache
7.Rash
8.Alteration in liver enzyme
Contra-indications of Fluconazole1.Hypersensitivity to Fluconazole and other Azole antifungalsSpecial Precautions while taking Fluconazole1. Hepatic dysfunctionPregnancy Related InformationContraindicatedOld Age Related InformationUse with caution.Breast Feeding Related InformationContraindicatedChildren Related InformationCHILDREN below13:Use with caution.
NEONATES:contraindicatedIndications for Fluconazole1.Oesophageal candidiasis
2.Oropharyngeal candidiasis
3.Vaginal candidiasis
4.Systemic candidiasis
5.Cryptococcal meningitis
6.Coccidioidomycosis
7.Histoplasmosis
8.Prophylaxis in bone marrow transplantation
9.Candidiasis in immunocompromised individuals
10.Peritonitis
Interactions for FluconazoleCimetidine: Decreased efficacy of fluconazole.
Cyclosporine: Increase in serum cyclosporine plasma concentration.
Hydrochlorothiazide: Reduction in renal clearance of fluconazole.
Phenytoin: Efficacy of phenytoin enhanced.
Rifampicin: Efficacy of fluconazole decreased, higher dosage required.
Sulfonylureas: Efficacy of tolbutamide, glyburide and glipizide increased.
Warfarin: Potentiates the anticoagulant effect resulting in increase in prothrombin time.
Typical Dosage for FluconazoleAdult: 200 - 400 mg once daily
Systemic candidiasis: Maximum dose: 400 mg .The drug should be administered 2 more weeks after resolution of symptoms.
Oropharyngeal candidiasis: Initial dose: 200 mg once daily followed by 100 mg once daily. The drug should be administered at least 14 days after resolution of symptoms.
Oesophageal candidiasis: Initial dose: 200 mg once daily followed by 100 mg once daily and dose can be increased to 400 mg. The drug should be administered at least 14 days after resolution of symptoms.
Cryptococcal Meningitis: : Initial dose: 400 mg once daily followed by 200 mg once daily for 2 - 3 month until CSF culture is negative.
Vaginal candidiasis: 150 mg once daily
Peritonitis: 50 - 200 mg once daily.
Before bone marrow transplantation as prophylaxis:400 mg once daily for several days before transplantation and after 7 days after Neutrophil count rises above 1000 cells per cub.mm.
Candidiasis in immunocompromised individuals: 100 -200 mg once daily.
CHILDREN:
2 - 8 mg / kg body weight /day
Systemic candidiasis: 6 - 12 mg / kg body weight /day
Oropharyngeal candidiasis: Initial dose: 6 mg / kg body weight / day followed by 3 mg / kg body weight / day. The drug should be administered at least 14 days after resolution of symptoms.
Schedule of FluconazoleN/AStorage Requirements for FluconazoleThe drug should be stored in room temperature. Keep away from moisture and sunlight.Effects of Missed Dosage of FluconazoleTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose and continue the regular schedule.Effects of Overdose of FluconazoleGive supportive measures and treatment.Secnidazole
About SecnidazoleA nitroimidazole derivative, Antiprotozoal.Mechanism of Action of SecnidazoleSecnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which exerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization & strand breakage has been observed.Pharmacokinets of SecnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed
Metabolism: Metabolized in liver, Excretion: Excreted in urine.
Onset of Action for SecnidazoleWithin few hoursDuration of Action for SecnidazoleBelow 24 hoursHalf Life of Secnidazole17 to 29 hoursSide Effects of Secnidazole1. Anorexia,
2. Glossitis,
3. Nausea,
4. Vomiting,
5. Diarrhoea,
6. Fatigue,
7. Dry mouth,
8. Abdominal distress,
9. Headache,
10. Dizziness,
11. Rash,
12. Urticaria,
13. Leucopenia,
Contra-indications of SecnidazoleHypersensitivity to the drugSpecial Precautions while taking Secnidazole1.Hepatic impairment
2.Alcoholic cirrhosis
3.In obstructive liver diseases
4.Use cautiously along with other hepatotoxic drugs & In visual field changes
5 Avoid alcohol use during therapy
6.Neurological disorders
Pregnancy Related InformationUse with caution, but contra indicated in first trimesterOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Secnidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Bacterial vaginosis
Interactions for SecnidazoleAnticoagulants: May potentiate anticoagulant effect of warfarin; increased risk of haemorrhage.
Disulfiram: Antabuse-like effects.
Cimetidine: Half-life of secnidazole is prolonged.
Lithium: Plasma levels of lithium increased leading to toxicity.
Typical Dosage for SecnidazoleAmoebiasis, Trichomoniasis & Giardiasis
Adults: 2gm once only dosage
Children: 30 mg/kg once only
Schedule of SecnidazoleHStorage Requirements for SecnidazoleStore in cool dry place.Protect from heat nd light.Keep out of the reach of children.Effects of Missed Dosage of SecnidazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SecnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, administration of activated charcoal & use of cathartics. For controlling seizures diazepam & phenytoin may be used.Azithromycin
About AzithromycinAn Azalide, macrolide antibiotic.
Mechanism of Action of AzithromycinAzithromycin is a member of macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they: interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Azithromycin is active against both gram positive and gram negative aerobic and anaerobic bacteriaPharmacokinets of AzithromycinAbsorption: Azithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is not metabolized in the body. Excretion: It is primarily excreted through bile and a very small amount excreted through urine.Onset of Action for Azithromycin1-2 hours.Duration of Action for AzithromycinN/AHalf Life of Azithromycin68 hourSide Effects of Azithromycin1. Nausea
2.Vomiting
3.Diarrhoea
4.Epigastric pain
5.Angioedema
6.Rash
7.Urticaria
8.Headache
9.Dizziness
10.Fever
11.Cholestatic jaundice
12.Hearing disturbances
13.Vertigo
Contra-indications of Azithromycin1.Hypersensitivity to Azithromycin and other macrolideSpecial Precautions while taking Azithromycin1.Renal impairment
2.Hepatic dysfunction
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with cautionIndications for Azithromycin1.Pneumonia
2.Tonsilitis
3.Pharyngitis
4.Sinusitis
5.Urethritis
6.Cervicitis
7.SABE
8.Trachoma
9.Prevention of disseminated Mycobacterium avium complex infection
10.Otitis media
11.Chancroid
12..Acne
13.Urogenital infection
14.Skin and soft tissue infections
15.Toxoplasmosis
Interactions for AzithromycinAluminium & Magnesium containing Antacids: Decrease peak serum levels.
Theophylline: Serum concentration of Theophylline increased.
Warfarin: Anticoagulant effects enhanced.
Digoxin & Cyclosporine: Increase in their serum concentration.
Carbamazepine: Toxicity occurs which may require hospitalization.
Triazolam: Increases serum levels of Triazolam leading to toxicity.
Ergot Alkaloids: Acute ergotism manifested as peripheral ischaemia.
Food: Absorption reduced by as much as 52% (should be taken 1 hr before or 2 hrs after meal).
Typical Dosage for AzithromycinAdult:
500 mg once daily for 1 day followed by 250 mg once daily for 4 days.
For the treatment of urethritis and cervicitis: 1 - 2 g as a single dose
Prophylaxis of MAC: 1200 mg once weekly
Chancroid: 1000 mg as a single dose
Children: 10 mg / kg body weight once daily on 1 day followed by 5 mg / kg body weight once daily for 4 days.
Schedule of AzithromycinHStorage Requirements for AzithromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of AzithromycinTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of AzithromycinGive supportive measures and symptomatic treatmentHome Delivery for Fluconazole + Secnidazole + Azithromycin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluconazole + secnidazole + azithromycin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluconazole + secnidazole + azithromycin and other medicines and health products. Home delivery services for fluconazole + secnidazole + azithromycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take fluconazole + secnidazole + azithromycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluconazole + secnidazole + azithromycin before they complete the sale. You can get this information while placing the order for fluconazole + secnidazole + azithromycin with the pharmacy.
Fluconazole + Secnidazole + Azithromycin is a generic medicine name and there are several brands available for it. Some of the brands for fluconazole + secnidazole + azithromycin might be better known than fluconazole + secnidazole + azithromycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluconazole + secnidazole + azithromycin in stock, you can ask for one of the branded alternatives for fluconazole + secnidazole + azithromycin.