Griseofulvin Pharmacology

Griseofulvin

About Griseofulvin
Penicillium antibiotic,Mitotic inhibitor, Oral antifungal.
Mechanism of Action of Griseofulvin
Griseofulvin is a fungistatic drug. It disorients microtubule and inhibits mitosis especially at metaphase. It actually prevents the separation of the 2 daughter chromosomes. This results in multinucleated and stunted fungal hyphae
Pharmacokinets of Griseofulvin
Absorption: It is well absorbed after oral administration.Distribution: It is mainly distributed to skin, hair, nail, skeletal muscle
Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted mainly through urine and also through faeces
Onset of Action for Griseofulvin
Few weeks to few months
Duration of Action for Griseofulvin
1 day
Half Life of Griseofulvin
24 - 36 hours
Side Effects of Griseofulvin
1.Headache
2.Bleeding
3.Nausea
4.Vomiting
5.Diarrhoea
6.Rash
7.Photosensitivity
8.Granulocytopenia
9.Albuminuria
10.Peripheral neuritis
11.Vertigo
Contra-indications of Griseofulvin
1.Hypersensitivity to Griseofulvin
2.Liver failure
3.Porphyria
Special Precautions while taking Griseofulvin
Penicillin sensitive patients
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use wih caution
Breast Feeding Related Information
Use wih caution
Children Related Information
Above 2 years: may be used

Indications for Griseofulvin
1.Tinea cruris
2.Tinea capitis
3.Tinea corporis
4.Tinea barbae
5.Tinea unguium
6.Tinea pedis
Interactions for Griseofulvin
Anticoagulants: Griseofulvin may decrease the efficacy of anticoagulants.
Barbiturates: Depress the serum levels of griseofulvin.
Oral contraceptives: Efficacy of oral contraceptives decreased leading to breakthrough bleeding, amenorrhoea or pregnancy.
Alcohol: Disulfiram like reaction (flushing, nausea, giddiness).
Food: High fat meal enhances absorption.
Typical Dosage for Griseofulvin
Adult: 125 - 250 mg every 6 hourly
Tinea infection of body and skin requires 3 weeks treatment
Tinea infection of palm and sole requires 4 - 6 weeks treatment
Tinea infection of finger and nail requires 4 - 6 months treatment
Tinea infection of toe and nail requires 8 - 12 months treatment
Schedule of Griseofulvin
N/A
Storage Requirements for Griseofulvin
The drug should be stored in room temperature. Keep away from moisture and sunlight.

Effects of Missed Dosage of Griseofulvin
Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Griseofulvin
Give supportive measures and treatment. Induce emesis or gastric lavage has to be done followed by charcoal administration.

Home Delivery for Griseofulvin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including griseofulvin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for griseofulvin and other medicines and health products. Home delivery services for griseofulvin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take griseofulvin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for griseofulvin before they complete the sale. You can get this information while placing the order for griseofulvin with the pharmacy.

Griseofulvin is a generic medicine name and there are several brands available for it. Some of the brands for griseofulvin might be better known than griseofulvin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have griseofulvin in stock, you can ask for one of the branded alternatives for griseofulvin.