Colistin Sulphate Pharmacology

Colistin Sulphate

About Colistin Sulphate
A polymyxin antibiotic(mixture of cyclic polypeptides colistin A and B).
Mechanism of Action of Colistin Sulphate
Colistin is a member of poly peptide antibiotic. Being poly peptide they exert a detergent like effect. They have high affinity for phospholipids. Peptide molecules orient between these phospholipids and cause cell membrane distortion and amino acids and ions come out with in the cell.Colistin is useful against gram negative bacteria only.
Pharmacokinets of Colistin Sulphate
Absorption: It is well absorbed after parenteral administration. Distribution: It is very widely distributed in the body.Metabolism: It does not undergo significant metabolism.Excretion: It is excreted mainly through urine.
Onset of Action for Colistin Sulphate
N/A
Duration of Action for Colistin Sulphate
N/A
Half Life of Colistin Sulphate
N/A
Side Effects of Colistin Sulphate
1.Pain at the site of injection
2.Nystagmus
3.Flushing
4.Nausea
5.Vomiting
6.Diarrhoea
7.Rash
8.Partial deafness
9.Pruritis
10.Ataxia
11.Vertigo
12.Nephrotoxicity
13.Disturbances of vision
14.Slurred speech
15.Super infection
Contra-indications of Colistin Sulphate
1.Hypersensitive to Colistin and other polypeptide antibiotic
2 Myasthenia gravis
Special Precautions while taking Colistin Sulphate
1.Perforated ear drum
2.Renal dysfunction
3.Porphyria
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
Indications for Colistin Sulphate
1.Enteric infection
2.Systemic infection
3.Urinary tract infection
Interactions for Colistin Sulphate
N/A
Typical Dosage for Colistin Sulphate
Adult :( IM / IV):2.5 - 5 mg / kg body weight / day in 2 - 4 divided dose
Children (IM/IV) 2.5 - 5 mg /kg body weight in 2 - 4 divided dose
Schedule of Colistin Sulphate
H
Storage Requirements for Colistin Sulphate
Store in a cool and dry place. Keep away from heat and moisture.

Effects of Missed Dosage of Colistin Sulphate
Take the missed dose as soon as noticed. If it is the time to take the next dose then take that dose and skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Colistin Sulphate
Give supportive measures and symptomatic treatment.

Home Delivery for Colistin Sulphate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including colistin sulphate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for colistin sulphate and other medicines and health products. Home delivery services for colistin sulphate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take colistin sulphate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for colistin sulphate before they complete the sale. You can get this information while placing the order for colistin sulphate with the pharmacy.

Colistin Sulphate is a generic medicine name and there are several brands available for it. Some of the brands for colistin sulphate might be better known than colistin sulphate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have colistin sulphate in stock, you can ask for one of the branded alternatives for colistin sulphate.