Clindamycin Pharmacology

Clindamycin

About Clindamycin
Macrolide, Lincosamide Antibiotic.
Mechanism of Action of Clindamycin
It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis. Along with Quinine sulfate, Clindamycin is used in the treatment of Chloroquine resistant falciparum malaria.
Pharmacokinets of Clindamycin
Absorption: It is well absorbed after oral administration.Distribution: It is very widely distributed in the body as protein bound form.Metabolism: Small amount is metabolized in the liver to inactive compound.Excretion: The drug is excreted through urine and small amount through bile and breast milk.
Onset of Action for Clindamycin
With in minutes
Duration of Action for Clindamycin
6 hour
Half Life of Clindamycin
3 hour
Side Effects of Clindamycin
1.Abdominal pain
2.Nausea
3.Vomiting
4.Diarrhoea
5.Pseudomembrnous colitis
6.Urticaria
7.Rash
8.Dermatitis
9.Anaphylaxis
10.Leucopenia
11.Eosinophilia
Contra-indications of Clindamycin
1.Hypersensitive to Clindamycin
2.Ulcerative colitis
Special Precautions while taking Clindamycin
1.Hepatic dysfunction
2.Renal impairment
3.Asthma
4.Allergy
Pregnancy Related Information
Contra indicated
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contra indicated
Children Related Information
Use with caution.
Indications for Clindamycin
1 Intra abdominal abscess
2.Lung abscess
3.Acne
4.Toxoplasmosis
5.Peritonitis
6.Endocarditis
7.Malaria
8.Empyema
9.Skin and soft tissue infection
10.Bacterial vaginosis
Interactions for Clindamycin
Neuromuscular blocking agents: Efficacy of these agents (e.g. tubocurarine) enhanced.
Cholinergics: Effects of neostigmine and pyridostigmine antagonised.
Erythromycin: Antagonism
Typical Dosage for Clindamycin
Adult: 150 - 300 mg four times daily
Severe infection: 300 - 450 mg four times daily
Malaria: 450 mg 3 times daily for 7 days in a regimen with quinine sulfate
Bacterial vaginosis: 300mg twice daily for 7 days
Children:8 - 16 mg / kg body weight/day in 3 - 4 divided dose
Severe infection: 16 - 20 mg/ kg body weight/ day in 3 - 4 divided dose

Schedule of Clindamycin
H
Storage Requirements for Clindamycin
The drug should be store at room temperature.
Effects of Missed Dosage of Clindamycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clindamycin
Give supportive measures and symptomatic treatment.

Home Delivery for Clindamycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clindamycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clindamycin and other medicines and health products. Home delivery services for clindamycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clindamycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clindamycin before they complete the sale. You can get this information while placing the order for clindamycin with the pharmacy.

Clindamycin is a generic medicine name and there are several brands available for it. Some of the brands for clindamycin might be better known than clindamycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clindamycin in stock, you can ask for one of the branded alternatives for clindamycin.