Sulphadoxine Pharmacology

Sulphadoxine

About Sulphadoxine
An ultra-long-lasting sulfonamide, Antimalarial with pyrimethamine.
Mechanism of Action of Sulphadoxine
Sulphadoxine is a structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of dihydrofolic acid, a compound that bacteria must be able to make in order to survive for the synthesis of folic acid, an important metabolite in DNA synthesis. It is usually given with Pyrimethamine in the treatment of Chloroquine resistant Plasmodium falciparum in a fixed dose formulation.
Pharmacokinets of Sulphadoxine
Absorption: Sulfadoxine is readily absorbed from the gastrointestinal tract. Distribution: It is distributed mainly in protein bound form. It is widely distributed to body tissues and fluids and it passes into the fetal circulation. Excretion: It is excreted very slowly in urine mainly in unchanged form.
Onset of Action for Sulphadoxine
N/A
Duration of Action for Sulphadoxine
N/A
Half Life of Sulphadoxine
4 to 9 days.
Side Effects of Sulphadoxine
1. Brownish coloration of urine
2. Skin rashes
3. Hives
4. Itching
5. Localized swelling
6. Reddened eyes
7. Headache
8. Dizziness
9. Ringing in ears
10. Loss of appetite
11. Irritation of mouth and tongue
12. Nausea
13. Abdominal pain
14. Diarrhea
Contra-indications of Sulphadoxine
1. Hypersensitivity to the drug or other ingredients it or other sulfonamides
2. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
3. Kidney disease
4. Liver disease
5. Porphyria
6. Anemia or other blood problems
Special Precautions while taking Sulphadoxine
1.Renal impairment
2.Hepatic impairment
3.Blood disorders
4.Drink lots of high calorie fluids such as cranberry juice and nectars, up to 2 quarts daily, to make sure you have adequate volume of urine to prevent dehydration.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Sulphadoxine
1. Malaria along with Pyrimethamine
Interactions for Sulphadoxine
N/A
Typical Dosage for Sulphadoxine
Adult: Initially 2 g, followed by 1 to 1.5 g weekly.
Children: 250 mg - 1 g dose is depend on body weight of children.
Schedule of Sulphadoxine
H
Storage Requirements for Sulphadoxine
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light.
Effects of Missed Dosage of Sulphadoxine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sulphadoxine
Give symptomatic and supportive treatment. Induce gastric lavage. Treat with blood products if needed.

Home Delivery for Sulphadoxine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sulphadoxine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sulphadoxine and other medicines and health products. Home delivery services for sulphadoxine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sulphadoxine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sulphadoxine before they complete the sale. You can get this information while placing the order for sulphadoxine with the pharmacy.

Sulphadoxine is a generic medicine name and there are several brands available for it. Some of the brands for sulphadoxine might be better known than sulphadoxine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sulphadoxine in stock, you can ask for one of the branded alternatives for sulphadoxine.