Sulfadiazine Pharmacology

Sulfadiazine

About Sulfadiazine
Short acting sulfonamide, Antibiotic.
Mechanism of Action of Sulfadiazine
Sulfadiazine is a short-acting sulfonamide. Sulfadiazine is a structural analogs and competitive antagonists of para-aminobenzoic acid (PABA). They inhibit normal bacterial utilization of PABA for the synthesis of dihydrofolic acid, a compound that bacteria must be able to make in order to survive for the synthesis of folic acid, an important metabolite in DNA synthesis. It is usually given with Pyrimethamine in the treatment of Chloroquine resistant Plasmodium falciparum in a fixed dose formulation.
Sulfadiazine has also been used with other sulfonamides, particularly Sulfamerazine and Sulfadimidine, to reduce the problems of low solubility in urine.

Pharmacokinets of Sulfadiazine
Pharmaco Kinetic
Absorption: Sulfadiazine is readily absorbed from the gastrointestinal tract.
Distribution: About 20 - 55% of the drug is distributed in protein bound form.It penetrates into the CSF. Excretion: Drug and its metabolites are excreted in urine.
Onset of Action for Sulfadiazine
N/A
Duration of Action for Sulfadiazine
N/A
Half Life of Sulfadiazine
10 hours
Side Effects of Sulfadiazine
1.Loss of appetite
2.Diarrhoea.
3.Headache
4.Fatigue
5.Dizziness
6.Difficulty sleeping
7.Allergic reactions
Contra-indications of Sulfadiazine
N/A
Special Precautions while taking Sulfadiazine
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Sulfadiazine
1.Nocardiosis
2.Lymphogranuloma venereum
3.Rheumatic fever in penicillin-allergic patients
4.Toxoplasmosis
Interactions for Sulfadiazine
N/A
Typical Dosage for Sulfadiazine
Adult: Initial doses of 2 to 4 g, followed by up to 6 g daily in divided doses.
Children:
Initial dose: 75 mg/kg, then 150 mg/kg daily in divided doses to a maximum of 6 g daily. Infants less than 2 months:
Congenital toxoplasmosis: 50 mg/kg twice daily for 12 months
Toxoplasmosis (Immuno compromised patients): 4 to 6 g daily in 4 divided doses for at least 6 weeks, followed by 2 to 4 g daily
For the prophylaxis of rheumatic fever: 500mg - 1 g daily
Schedule of Sulfadiazine
N/A
Storage Requirements for Sulfadiazine
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light.
Effects of Missed Dosage of Sulfadiazine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Sulfadiazine
Give symptomatic and supportive treatment. Induce gastric lavage.

Home Delivery for Sulfadiazine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sulfadiazine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sulfadiazine and other medicines and health products. Home delivery services for sulfadiazine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sulfadiazine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sulfadiazine before they complete the sale. You can get this information while placing the order for sulfadiazine with the pharmacy.

Sulfadiazine is a generic medicine name and there are several brands available for it. Some of the brands for sulfadiazine might be better known than sulfadiazine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sulfadiazine in stock, you can ask for one of the branded alternatives for sulfadiazine.