Tigecycline Pharmacology

Tigecycline

About Tigecycline
A tetracycline derivative(glycylcycline), Antibiotic.
Mechanism of Action of Tigecycline
Tigecycline has expanded broad spectrum antibacterial activity. It produces its action by attaching to 30 S subunit of bacterial ribosome. This will interfere the attachment of aminoacyl- tRNA to the mRNA-ribosome complex and subsequently preventing protein synthesis. In addition to Tetracycline activity it also has activity against Tetracycline resistant organisms.
Pharmacokinets of Tigecycline
Absorption: It is completely absorbed after intravenous administration. Distribution: It is extensively distributed in the body.
Metabolism: Tigecycline is not extensively metabolized in the liver and
secondarily through urine.
Onset of Action for Tigecycline
N/A
Duration of Action for Tigecycline
N/A
Half Life of Tigecycline
42.4 hours
Side Effects of Tigecycline
1.Inflammation and pain at injection site
2.Diarrhoea
3.Nausea
4.Tachycardia
5.Vasodilatation
6.Anorexia
7.Dry mouth
8.Hypocalcemia
9.Hypoglycemia
10.Somnolence
11.Taste perversion
12.Vaginitis
13.Eosinophilia
14. Thrombophlebitis
15. Bradycardia
Contra-indications of Tigecycline
Hypersensitivity to Tigecycline
Special Precautions while taking Tigecycline
Hepatic impairment
Renal impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Tigecycline
1.Skin and skin structure infections
2.Intra-abdominal infections
Interactions for Tigecycline
N/A
Typical Dosage for Tigecycline
Intravenous infusion:
Initial dose: 100 mg as Intravenous infusion over 30 to 60 minutes, followed by 50 mg every 12 hours for 5 - 14 days.
Schedule of Tigecycline
N/A
Storage Requirements for Tigecycline
N/A
Effects of Missed Dosage of Tigecycline
N/A
Effects of Overdose of Tigecycline
Give supportive measures and symptomatic treatment.

Home Delivery for Tigecycline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tigecycline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tigecycline and other medicines and health products. Home delivery services for tigecycline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tigecycline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tigecycline before they complete the sale. You can get this information while placing the order for tigecycline with the pharmacy.

Tigecycline is a generic medicine name and there are several brands available for it. Some of the brands for tigecycline might be better known than tigecycline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tigecycline in stock, you can ask for one of the branded alternatives for tigecycline.