Demeclocycline Pharmacology

Demeclocycline

About Demeclocycline
Tetracycline Derivative Antibiotic, A broad spectrum antibiotic.
Mechanism of Action of Demeclocycline
Demeclocycline is a broad spectrum antibiotic which has action against both gram positive organisms & gram negative organisms. It exerts its bacteriostatic action by accumulating inside the bacteria through specific transporter protein & inhibits bacterial protein synthesis by attaching to 30S subunit of bacterial ribosome (which are absent in mammals). Demeclocycline interfering the attachment of aminoacyl-tRNA to the mRNA-ribosome complex and peptide chain fails to grow. It chelates cations like Ca & Mg and inhibits functioning of various enzymes & ribosome.

Pharmacokinets of Demeclocycline
Absorption: orally well absorbed, food reduces absorption Distribution: widely distributed; shows protein- binding, Metabolism: Not metabolized, Excretion: excreted through urine. A small amount of drug is present in breast milk

Onset of Action for Demeclocycline
3 hours
Duration of Action for Demeclocycline
12-16 hours
Half Life of Demeclocycline
16 to18 hours
Side Effects of Demeclocycline
1.Headache
2.Dizziness
3.Intracranial
4.Hypertension
5.Nausea
6.Vomiting
7.Diarrhoea
8.Epigastric distress
9.Pancreatitis
10.Super infection
11.Skin rashes
12.Hypersensitivity reactions
13.Pericarditis
14.Neutropenia
15.Thrombocytopenia
16.Elevated liver enzymes
17.Discoloration of teeth
18.Retardation of bone growth
13.Esophageal ulceration

Contra-indications of Demeclocycline
1.Hypersensitive individuals

Special Precautions while taking Demeclocycline
1.Renal impairment:
2.Hepatic impairment:
3.Avoid use together with milk & milk products, Antacids, Cations, Vitamins, Products which contain divalent or trivalent cations
4.Potentiation of action of anticoagulants; so avoid use together.
5.Diabetes mellitus
6.Hyperthyroidism
7.Hypertensions

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Neonates:Contraindicated
Indications for Demeclocycline
1.Pneumonia
2.Chlamydia infections
3.Rickettsial infections
4.Brucellosis
5.Sexually transmitted diseases like Syphilis, Gonorrhea, Chancroid
6.Urinogenital tract infections
7.Ophthalmic infections
8.Dental infections
9.ENT infections
Interactions for Demeclocycline
Antacids (aluminium, calcium, zinc, magnesium), Iron salts, Bismuth salts: Impair absorption of demeclocycline thus reducing its efficacy.
Anticoagulants: Increases the hypothrombinemic effects of anti-coagulants.
Cimetidine: Decreases GI absorption leading to decreased efficacy of demeclocyline.
Digoxin: Increases serum levels leading to digoxin toxicity.
Methoxyflurane: Nephrotoxic effects of both increased.
Oral contraceptives: Breakthrough bleeding or pregnancy due to decreased efficacy.
Penicillins: Efficacy reduced.
Food: Dairy products decrease efficacy of demeclocycline.
Lab Tests: Bacteriosuppressive levels of demeclocycline persist in both urine and blood interfering with culture studies.

Typical Dosage for Demeclocycline
Adults: 300mg orally twice daily or 150mg orally four times daily
In severe infections: 300 mg orally thrice daily
Children (above 8years of age): 8 to12mg/kg/day 2 - 4times daily


Schedule of Demeclocycline
H
Storage Requirements for Demeclocycline
Store in a cool place.

Effects of Missed Dosage of Demeclocycline
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Demeclocycline
Treatment is supportive & symptomatic. Gastric lavage & administration of antacids as soon as possible

Home Delivery for Demeclocycline in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including demeclocycline.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for demeclocycline and other medicines and health products. Home delivery services for demeclocycline may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take demeclocycline only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for demeclocycline before they complete the sale. You can get this information while placing the order for demeclocycline with the pharmacy.

Demeclocycline is a generic medicine name and there are several brands available for it. Some of the brands for demeclocycline might be better known than demeclocycline itself. If the pharmacy that's willing to deliver medicines to your home doesn't have demeclocycline in stock, you can ask for one of the branded alternatives for demeclocycline.