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- Pharmacology For Roxithromycin + Serratiopeptidase
Roxithromycin + Serratiopeptidase Pharmacology
Roxithromycin + Serratiopeptidase
About Roxithromycin + SerratiopeptidaseN/AMechanism of Action of Roxithromycin + SerratiopeptidaseN/APharmacokinets of Roxithromycin + SerratiopeptidaseN/AOnset of Action for Roxithromycin + SerratiopeptidaseN/ADuration of Action for Roxithromycin + SerratiopeptidaseN/AHalf Life of Roxithromycin + SerratiopeptidaseN/ASide Effects of Roxithromycin + SerratiopeptidaseN/AContra-indications of Roxithromycin + SerratiopeptidaseN/ASpecial Precautions while taking Roxithromycin + SerratiopeptidaseN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Roxithromycin + SerratiopeptidaseN/AInteractions for Roxithromycin + SerratiopeptidaseN/ATypical Dosage for Roxithromycin + SerratiopeptidaseN/ASchedule of Roxithromycin + SerratiopeptidaseN/AStorage Requirements for Roxithromycin + SerratiopeptidaseN/AEffects of Missed Dosage of Roxithromycin + SerratiopeptidaseN/AEffects of Overdose of Roxithromycin + SerratiopeptidaseN/ARoxithromycin
About RoxithromycinIt is a semi-synthetic macrolide, Antibiotic.Mechanism of Action of RoxithromycinRoxithromycin is a semi synthetic long acting macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.Pharmacokinets of RoxithromycinAbsorption: Roxithromycin is absorbed after oral administration.
Distribution: It is widely distributed in the body in protein bound form. Metabolism: small portion undergo metabolism.
Excretion: It is primarily excreted through bile and also excreted through urine and breast milk
Onset of Action for Roxithromycin1 - 2 hoursDuration of Action for Roxithromycin8 - 12 hoursHalf Life of RoxithromycinN/ASide Effects of Roxithromycin1. Nausea
2. Vomiting
3. Diarrhoea
4. Epigastric pain
5. Fever
6. Rash
7. Urticaria
8. Increase in liver enzyme concentrations
Contra-indications of Roxithromycin1. Hypersensitivity to Roxithromycin and other macrolide
2. Use of ergotamine type compound along with Roxithromycin
Special Precautions while taking Roxithromycin1. Hepatic dysfunctionPregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Roxithromycin1. Pneumonia
2. Tonsilitis
3. Pharyngitis
4. Bronchitis
5. ENT infection
6. Tetanus
7. Diphtheria
8. Sinusitis
9. Gonorrhea
10. Wound and burn infection
11. Skin and soft tissue infections
12. Pertusis
13. Urogenital infection
Interactions for RoxithromycinDigoxin: Increases absorption.
Midazolam: Increases its half-life.
Terfenadine: Serum levels elevated leading to ventricular arrhythmias.
Disopyramide: Displaced from its protein bound sites.Typical Dosage for RoxithromycinAdult: 300 mg in two divided dose for 1 - 2 week
Children: 4 - 8 mg/kg body weight/day in divided dose
Schedule of RoxithromycinHStorage Requirements for RoxithromycinStore in a cool dark place. Keep away from heat and moisture.Effects of Missed Dosage of RoxithromycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RoxithromycinGive supportive measures and treatmentSerratiopeptidase
About SerratiopeptidaseA proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.Mechanism of Action of SerratiopeptidaseThis anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.Pharmacokinets of SerratiopeptidaseOrally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.Onset of Action for SerratiopeptidaseN/ADuration of Action for Serratiopeptidase8 to 10 hrsHalf Life of SerratiopeptidaseN/ASide Effects of Serratiopeptidase1. Hypersensitivity
2. Anorexia
3. Gastric discomfort
4. Nausea
5. Vomiting
6. Epistaxis
7. Diarrhoea
8. Skin rash
Contra-indications of Serratiopeptidase1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase1. In patients with renal failure or hepatic failurePregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Serratiopeptidase1. Antiinflammatory
2. Antiswelling
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
6. Bronchitis
7. Fibrocystic breast swelling
8. Sinusitis
9. Cough
10. Laryngitis
11. Fibromyalgia
12. Emphysema
13. Gout
Interactions for SerratiopeptidaseN/ATypical Dosage for SerratiopeptidaseOral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of SerratiopeptidaseN/AStorage Requirements for SerratiopeptidaseStore below 25 degree Celsius, protect from light and moisture.Effects of Missed Dosage of SerratiopeptidaseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SerratiopeptidaseGive supportive measures and symptomatic treatment.Home Delivery for Roxithromycin + Serratiopeptidase in Your City
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Roxithromycin + Serratiopeptidase is a generic medicine name and there are several brands available for it. Some of the brands for roxithromycin + serratiopeptidase might be better known than roxithromycin + serratiopeptidase itself. If the pharmacy that's willing to deliver medicines to your home doesn't have roxithromycin + serratiopeptidase in stock, you can ask for one of the branded alternatives for roxithromycin + serratiopeptidase.