Clarithromycin Pharmacology

Clarithromycin

About Clarithromycin

It is a new macrolide antimicrobial drug.It is the most effective macrolide against Haemophilus influenzae, chlamydia trachomaitis and chlamydia pneumoniae.

Mechanism of Action of Clarithromycin

Clarithromycin is a member of macrolide antibiotic.It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl tRNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.

Pharmacokinets of Clarithromycin

Absorption: Clarithromycin is completely absorbed after oral administration. Distribution: It is widely distributed in the body .Metabolism: It is metabolized in to active and inactive compound .Excretion: It is excreted through urine.

Onset of Action for Clarithromycin

0.5 - 1 hour

Duration of Action for Clarithromycin

8 - 12 hour

Half Life of Clarithromycin

N/A

Side Effects of Clarithromycin

1.Nausea
2.Vomiting
3.Diarrhoea
4.Epigastric pain
5.Abnormal taste
6.Headache
7.Dizziness
8.Elevated hepatic enzyme
9.Pseudomembranous colitis

Contra-indications of Clarithromycin

1.Hypersensitivity to clarithromycin and other macrolide
2.Liver disease

Special Precautions while taking Clarithromycin

1.Renal impairment
2.Hepatic dysfunction
3.cardiac abnormalities

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

N/A

Indications for Clarithromycin

1.Tonsilitis
2.Pharyngitis
3.Pneumonia
4.Skin and soft tissue infections
5.Bronchitis
6.Otitis media
7.Prophylaxis of MAC
8.Leprosy
9.Acne
10.Nocardiosis

Interactions for Clarithromycin

Terfenadine: Concomitant use may cause cardiac arrhythmia.
Carbamazepine & Theophylline: Concurrent use causes increase in serum levels of these drugs.
Zidovudine: In HIV infected patients steady state Zidovudine levels decreased.
Increased efficacy of the following drugs which are metabolised by the cytochrome P450 system: Digoxin, Warfarin, Ergot alkaloids, Triazolam, Midazolam and Cyclosporine.

Typical Dosage for Clarithromycin

Adult: 250 - 500 mg twice daily for 1 - 2 week
Children: 7.5 mg/kg body weight two times daily for 1 - 2 week

Schedule of Clarithromycin

Storage Requirements for Clarithromycin

Store in a cool dark place. Keep away from heat and moisture.

Effects of Missed Dosage of Clarithromycin

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Clarithromycin

Give supportive measures and treatment

Home Delivery for Clarithromycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clarithromycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clarithromycin and other medicines and health products. Home delivery services for clarithromycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clarithromycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clarithromycin before they complete the sale. You can get this information while placing the order for clarithromycin with the pharmacy.

Clarithromycin is a generic medicine name and there are several brands available for it. Some of the brands for clarithromycin might be better known than clarithromycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clarithromycin in stock, you can ask for one of the branded alternatives for clarithromycin.