Spiramycin Pharmacology

Spiramycin

About Spiramycin
Macrolide Antibiotic, Antibacterial (systemic,antiprotozoal,In toxoplasmosis, cryptosporidiosis.
Mechanism of Action of Spiramycin
Spiramycin is a member of macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they: interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.
Pharmacokinets of Spiramycin
Absorption: Spiramycin is completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: It is excreted through bile
Onset of Action for Spiramycin
1.5 - 3 hours
Duration of Action for Spiramycin
N/A
Half Life of Spiramycin
8 hours
Side Effects of Spiramycin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Epigastric pain
5. Urticaria
6. Skin rash
7. Pruritis
Contra-indications of Spiramycin
1. Hypersensitivity to Spiramycin and other macrolide
Special Precautions while taking Spiramycin
1. Hepatic dysfunction
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Spiramycin
1. Tonsilitis
2. Pharyngitis
3. Prostatitis
4. Toxoplasmosis
5. Urethritis
6. Skin and soft tissue infections
7. Amebiasis
8. Cryptosporidiosis
Interactions for Spiramycin
Carbamazepine: Plasma levels of carbamazepine increased.
Terfenadine and astemizole: Risk of cardiac arrhythmias.
Digoxin: May lead to digoxin toxicity.
Theophylline: Increased adverse efects of this drug.
Oral anticoagulants: Risk of bleeding.
Typical Dosage for Spiramycin
Adult: 3 - 6 million IU two times daily
Toxoplasmosis in pregnancy: 6000000 - 9000000 IU /day in divided dose for 3 weeks; Repeat the dose after 2 weeks interval till delivery
Child: 75000 - 150000 IU units/kg body weight two times daily
Schedule of Spiramycin
H
Storage Requirements for Spiramycin
Store in a cool dark place. Keep away from heat and moisture.
Effects of Missed Dosage of Spiramycin
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Spiramycin
Give supportive measures and treatment.

Home Delivery for Spiramycin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including spiramycin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for spiramycin and other medicines and health products. Home delivery services for spiramycin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take spiramycin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for spiramycin before they complete the sale. You can get this information while placing the order for spiramycin with the pharmacy.

Spiramycin is a generic medicine name and there are several brands available for it. Some of the brands for spiramycin might be better known than spiramycin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have spiramycin in stock, you can ask for one of the branded alternatives for spiramycin.