Moxifloxacin Pharmacology

Moxifloxacin

About Moxifloxacin

A third generation synthetic fluoroquinolone Antibiotic, A broad spectrum antibiotic.

Mechanism of Action of Moxifloxacin

Moxifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Moxifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.

Pharmacokinets of Moxifloxacin

Absorption: They are adequately absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes hepatic metabolism. Excretion: Drug is excreted mainly through urine.

Onset of Action for Moxifloxacin

N/A

Duration of Action for Moxifloxacin

N/A

Half Life of Moxifloxacin

N/A

Side Effects of Moxifloxacin

1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Dizziness
6.Drowsiness
7.Rash
8.Headache
9.Photosensitivity

Contra-indications of Moxifloxacin

1.Hypersensitivity to Moxifloxacin and other Fluoroquinolones.

Special Precautions while taking Moxifloxacin

1.Hepatic impairment
2.Renal impairment
3.Seizure
4.Concomitant use of antiarrhythmic drugs.
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated
NEONATES: contraindicated

Indications for Moxifloxacin

1.Pneumonia
2.Bronchitis
3.Sinusitis
4.Skin infections

Interactions for Moxifloxacin

Antiarrhythmic agents (amiodarone, bretylium, disopyramide, procainamide, quinidine, sotalol): The risk of threatening cardiac arrhythmias may be increased.

Typical Dosage for Moxifloxacin

Adults: 400 mg once daily for 5 - 10 days
Dose is determined on the basis of severity of the infection, type of infecting organism.

Schedule of Moxifloxacin

Storage Requirements for Moxifloxacin

Store at room temperature in a tightly closed container.

Effects of Missed Dosage of Moxifloxacin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.

Effects of Overdose of Moxifloxacin

Give supportive measures and symptomatic treatment.

Home Delivery for Moxifloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including moxifloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for moxifloxacin and other medicines and health products. Home delivery services for moxifloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take moxifloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for moxifloxacin before they complete the sale. You can get this information while placing the order for moxifloxacin with the pharmacy.

Moxifloxacin is a generic medicine name and there are several brands available for it. Some of the brands for moxifloxacin might be better known than moxifloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have moxifloxacin in stock, you can ask for one of the branded alternatives for moxifloxacin.