Gatifloxacin + Ambroxol Pharmacology

Gatifloxacin + Ambroxol

About Gatifloxacin + Ambroxol

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Mechanism of Action of Gatifloxacin + Ambroxol

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Pharmacokinets of Gatifloxacin + Ambroxol

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Onset of Action for Gatifloxacin + Ambroxol

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Duration of Action for Gatifloxacin + Ambroxol

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Half Life of Gatifloxacin + Ambroxol

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Side Effects of Gatifloxacin + Ambroxol

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Contra-indications of Gatifloxacin + Ambroxol

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Special Precautions while taking Gatifloxacin + Ambroxol

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Pregnancy Related Information

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Old Age Related Information

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Breast Feeding Related Information

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Children Related Information

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Indications for Gatifloxacin + Ambroxol

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Interactions for Gatifloxacin + Ambroxol

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Typical Dosage for Gatifloxacin + Ambroxol

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Schedule of Gatifloxacin + Ambroxol

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Storage Requirements for Gatifloxacin + Ambroxol

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Effects of Missed Dosage of Gatifloxacin + Ambroxol

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Effects of Overdose of Gatifloxacin + Ambroxol

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Gatifloxacin

About Gatifloxacin

Fourth-generation fluoroquinolone, DNA Gyrase Inhibitor,Topoisomerase I Inhibitor, Antibiotic.

Mechanism of Action of Gatifloxacin

Gatifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Gatifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis in microorganisms.

Pharmacokinets of Gatifloxacin

Absorption: Gatifloxacin is well absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes limited metabolism. Excretion: Drug is excreted mainly through urine.

Onset of Action for Gatifloxacin

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Duration of Action for Gatifloxacin

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Half Life of Gatifloxacin

8 hour

Side Effects of Gatifloxacin

1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Vaginitis
6.Dizziness
7.Headache

Contra-indications of Gatifloxacin

Hypersensitivity to Gatifloxacin and other Fluoroquinolones

Special Precautions while taking Gatifloxacin

1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Concomitant use of antiarrhythmic drugs
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.
6.Avoid long exposure to sunlight.

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated
NEONATES: contraindicated

Indications for Gatifloxacin

1.Pneumonia
2.Bronchitis
3.Sinusitis
4.Urinary tract infections
5.Pyelonephritis
6.Skin and skin structure infections
7.Gonorrhoea.

Interactions for Gatifloxacin

Probenicid : Systemic exposure to gatifloxacin is increased following concomitant administration of gatifloxacin and probenicid.
Ferrous sulphate /Antacid : Systemic exposure is reduced when gatifloxacin is given concomitantly with Ferrous sulphate or with antacids containing aluminium or magnesium salts.

Typical Dosage for Gatifloxacin

Adults: 400 mg once daily for 1 - 2 week
Dose is determined on the basis of severity of the infection and type of infecting organism
Bronchitis: 400 mg once daily for 5 days
Sinusitis: 400 mg once daily for 10 days
Pneumonia: 400 mg once daily for 1 - 2 week
Skin and skin structure infections, Complicated UTI, Pyelonephritis: 400 mg once daily for 7 - 10 days
Uncomplicated UTI: 200 mg / day for 3 days
Gonorrhoea: 400 mg as a single dose.

Schedule of Gatifloxacin

Storage Requirements for Gatifloxacin

Store at room temperature in a tightly closed container.

Effects of Missed Dosage of Gatifloxacin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.

Effects of Overdose of Gatifloxacin

Give supportive measures and symptomatic treatment.

Ambroxol

About Ambroxol

Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.

Mechanism of Action of Ambroxol

Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.

Pharmacokinets of Ambroxol

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Onset of Action for Ambroxol

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Duration of Action for Ambroxol

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Half Life of Ambroxol

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Side Effects of Ambroxol

1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.

Contra-indications of Ambroxol

Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.

Special Precautions while taking Ambroxol

1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Ambroxol

1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.

Interactions for Ambroxol

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Typical Dosage for Ambroxol

Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily

Schedule of Ambroxol

Storage Requirements for Ambroxol

Store in a cool dry place and protect from light. Keep out of reach of children.

Effects of Missed Dosage of Ambroxol

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Ambroxol

Provide symptomatic treatment and supportive measures.

Home Delivery for Gatifloxacin + Ambroxol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including gatifloxacin + ambroxol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gatifloxacin + ambroxol and other medicines and health products. Home delivery services for gatifloxacin + ambroxol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take gatifloxacin + ambroxol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gatifloxacin + ambroxol before they complete the sale. You can get this information while placing the order for gatifloxacin + ambroxol with the pharmacy.

Gatifloxacin + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for gatifloxacin + ambroxol might be better known than gatifloxacin + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gatifloxacin + ambroxol in stock, you can ask for one of the branded alternatives for gatifloxacin + ambroxol.