Norfloxacin Pharmacology

Norfloxacin

About Norfloxacin
A synthetic second generation synthetic fluoroquinolone (quinolone), Broad spectrum Antibiotic.
Mechanism of Action of Norfloxacin
Norfloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Norfloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Norfloxacin
Absorption: About 30 - 40 % of the drug is absorbed after oral administration.
Distribution: It is distributed in the body.
Metabolism: It undergoes hepatic metabolism.
Excretion: Drug is excreted mainly through urine and also through faeces.
Onset of Action for Norfloxacin
0.5 - 1 hours
Duration of Action for Norfloxacin
8 - 12 hours
Half Life of Norfloxacin
3 - 4 hours
Side Effects of Norfloxacin
1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Seizure
6. Dizziness
7. Depression
8. Headache
9. Rash
10. Confusion
11. Insomnia
12. Anorexia
13. Pruritis
14. Photosensitivity

Contra-indications of Norfloxacin
1. Hypersensitivity to Norfloxacin and other Fluoroquinolones
Special Precautions while taking Norfloxacin
1. Hepatic impairment
2. Renal impairment
3. Epilepsy
4. Dehydration
5. Caution while driving the vehicle or operating machine or involved in any hazardous activities
6. Avoid exposure to sunlight.

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Norfloxacin
1. Urinary tract infection
2. Gonorrhoea
3. Typhoid fever
4. Gastroenteritis
5. Prostatitis
6. Traveler`s diarrhoea

Interactions for Norfloxacin
Antineoplastic drugs: Decrease serum levels of norfloxacin.
Caffeine: Enhanced efficacy of caffeine.
Oral anticoagulants: Enhanced effects of anticoagulants.
Cyclosporine: Nephrotoxicity increased by norfloxacin.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
Typical Dosage for Norfloxacin
Adults: 400 mg twice daily.
UTI: 800 mg / day in 2 divided doses for 3 - 21 days; Dose is determined on the basis of severity of the infection, type of infecting organism
Typhoid fever: 800 mg / day in 2 divided doses for 2 weeks.
Gonorrhoea: 800 mg / day as a single dose
Prostatitis: 800 mg / day in 2 divided doses for 4 weeks
Gastroenteritis: 800 mg / day in 2 divided doses for 5 days.
Traveler`s diarrhoea: 800 mg / day in 2 divided doses for up to 3 days
Schedule of Norfloxacin
H
Storage Requirements for Norfloxacin
Store at 15 - 30 degree C in a tightly closed container
Effects of Missed Dosage of Norfloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Norfloxacin
Give supportive measures and symptomatic treatment.

Home Delivery for Norfloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including norfloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for norfloxacin and other medicines and health products. Home delivery services for norfloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take norfloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for norfloxacin before they complete the sale. You can get this information while placing the order for norfloxacin with the pharmacy.

Norfloxacin is a generic medicine name and there are several brands available for it. Some of the brands for norfloxacin might be better known than norfloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have norfloxacin in stock, you can ask for one of the branded alternatives for norfloxacin.