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- Pharmacology For Cefixime + Lactobacillus
Cefixime + Lactobacillus Pharmacology
Cefixime + Lactobacillus
About Cefixime + LactobacillusN/AMechanism of Action of Cefixime + LactobacillusN/APharmacokinets of Cefixime + LactobacillusN/AOnset of Action for Cefixime + LactobacillusN/ADuration of Action for Cefixime + LactobacillusN/AHalf Life of Cefixime + LactobacillusN/ASide Effects of Cefixime + LactobacillusN/AContra-indications of Cefixime + LactobacillusN/ASpecial Precautions while taking Cefixime + LactobacillusN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Cefixime is contraindicated in breast feeding, the combination generic cannot be used in breast feedingChildren Related InformationN/AIndications for Cefixime + LactobacillusIt is a combination of third generation Cephalosporins Cefixime and probiotic Lactobacillus. Lactobacillus is used to prevent diarrhoea associated with the intake of Cefixime
1.Tonsillitis
2.Pharyngitis
3.Pneumonia
4.Bronchitis & other respiratory tract infections
5.Skin & soft tissue infections
6.Urinary tract infections
Interactions for Cefixime + LactobacillusN/ATypical Dosage for Cefixime + LactobacillusAdult:1 tablet to be taken 2 times daily.Schedule of Cefixime + LactobacillusN/AStorage Requirements for Cefixime + LactobacillusN/AEffects of Missed Dosage of Cefixime + LactobacillusN/AEffects of Overdose of Cefixime + LactobacillusN/ACefixime
About CefiximeThird Generation Cephalosporin Oral antibioticMechanism of Action of CefiximeCefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.Pharmacokinets of CefiximeAbsorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urineOnset of Action for CefiximeWithin one hourDuration of Action for Cefixime18 hoursHalf Life of Cefixime3 hourSide Effects of Cefixime1. Diarrhea & stool changes
2. Rashes & allergic manifestation
3. Vaginitis
4. Nephrotoxicity
5. Pseudo membranous colitis
6. Nausea
7. Vomiting
8. Elevated liver enzymes
9. Leucopenia
10.Thrombocytopenia
11. Headache
12. Dizziness
13.Pruritus
14.Candidiasis
Contra-indications of Cefixime1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 6 months: may be used
Neonates: contraindicatedIndications for Cefixime1.Tonsillitis
2.Pharyngitis
3.Otitismedia
4.Bronchitis
5.Urinary tract infections
6.Gonorrhea
7.Infections caused by susceptible organisms.
Interactions for CefiximeProbenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.Typical Dosage for CefiximeAdults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of CefiximeHStorage Requirements for CefiximeN/AEffects of Missed Dosage of CefiximeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefiximeAdopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis Lactobacillus
About LactobacillusLactic acid bacteria, Probiotic,Antidiarrhoeal.Mechanism of Action of LactobacillusLactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.Pharmacokinets of LactobacillusAbsorption: It is orally well absorbed after oral administration.
Onset of Action for LactobacillusN/ADuration of Action for LactobacillusN/AHalf Life of LactobacillusN/ASide Effects of Lactobacillus1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus1.Recent bowel surgery
2.Intestinal damage
3.Weakened immune system
Special Precautions while taking LactobacillusPatient on Inulin treatmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Lactobacillus1.Aphthous stomatitis
2.Hypochlorhydria
3.Hepatic encephalopathy
4.Adjuvant to antibiotic therapy
5.Diarrhoea.Interactions for LactobacillusN/ATypical Dosage for LactobacillusAdult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Suppositories:
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of LactobacillusN/AStorage Requirements for LactobacillusRefrigerate below 5 degree C.Effects of Missed Dosage of LactobacillusN/AEffects of Overdose of LactobacillusGive supportive measures and symptomatic treatmentHome Delivery for Cefixime + Lactobacillus in Your City
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