Cefoperazone Sodium Pharmacology

Cefoperazone Sodium

About Cefoperazone Sodium
A third generation cephalosporin antibiotic, Parenteral antibiotic.
Mechanism of Action of Cefoperazone Sodium
Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis
Pharmacokinets of Cefoperazone Sodium
Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed & good CSF penetration, Metabolism: It is not significantly metabolized inside the body. Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.

Onset of Action for Cefoperazone Sodium
Sudden
Duration of Action for Cefoperazone Sodium
12 hours
Half Life of Cefoperazone Sodium
2 hours
Side Effects of Cefoperazone Sodium
1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestation
3.Super infection
4.Pseudo membranous colitis
5.Nausea
6.Vomiting
7.Diarrhea
8.Elevated liver enzymes
9.Neutropenia
10.Hypoprothrombinemia
Contra-indications of Cefoperazone Sodium
1.Hypersensitivity to cephalosporins
2.Pseudo membranous colitis
Special Precautions while taking Cefoperazone Sodium
1.Renal impairment
2.Hepatic impairment
3 Patient allergic to penicillins
4.Neuromuscular disorders
5.Along with other nephrotoxic drugs
Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
Neonates: contraindicated
Indications for Cefoperazone Sodium
1.Meningitis
2.Biliary infections
3.Septicemia
4.Infections in immunocompromised patients
5.Urinary tract &genital tract infections
6.Surgical prophylaxis
7.Skin & soft tissue infections
8.Bone & Joint infections
9.Gonorrhea,
10.Peritonitis.
Interactions for Cefoperazone Sodium
Alcohol: Disulfiram like reaction upto 72 hours after cefoperazone intake.
Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated.
Oral anticoagulants: Hypothrombinemic effect potentiated, bleeding complications may occur.
Bacteriostatic agents like Chloramphenicol: Decreases efficacy of Cefoperazone sodium.
Probenecid: Slows tubular excretion and this enhances efficacy.
Frusemide & Ethacrynic Acid: Potentiate nephrotoxicity of Cefoperazone Sodium.
Lab. Test: Urine Glucose: False positive with Benedicts solution and Fehlings solution.
Direct Coomb?s Test: False positive.
Urinary 17-Ketosteroid values: Falsely elevated values.

Typical Dosage for Cefoperazone Sodium
Adults: 1g to 2gm I.M. or I.V. two times daily to three times daily.
In severe infections: 12gm/day in two to four divided doses
Children: 50 to 200 mg/kg/day I.M or I.V. two times daily
In meningitis child dosage: Up to 300mg/kg/day
Maximum adult dose: Up to 12gm/day
Maximum child dose: 300mg/kg/day

Schedule of Cefoperazone Sodium
H
Storage Requirements for Cefoperazone Sodium
Store in a refrigerator & away from light.
Effects of Missed Dosage of Cefoperazone Sodium
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefoperazone Sodium
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Hypoprothrombinemia may also occur. Treatment includes removal of drug from the body by dialysis, administration of vitamin K or blood products & supportive measures

Home Delivery for Cefoperazone Sodium in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefoperazone sodium and other medicines and health products. Home delivery services for cefoperazone sodium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefoperazone sodium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefoperazone sodium before they complete the sale. You can get this information while placing the order for cefoperazone sodium with the pharmacy.

Cefoperazone Sodium is a generic medicine name and there are several brands available for it. Some of the brands for cefoperazone sodium might be better known than cefoperazone sodium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefoperazone sodium in stock, you can ask for one of the branded alternatives for cefoperazone sodium.