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- Pharmacology For Folic Acid + L-Carnitine
Folic Acid + L-Carnitine Pharmacology
Folic Acid + L-Carnitine
About Folic Acid + L-CarnitineN/AMechanism of Action of Folic Acid + L-CarnitineN/APharmacokinets of Folic Acid + L-CarnitineN/AOnset of Action for Folic Acid + L-CarnitineN/ADuration of Action for Folic Acid + L-CarnitineN/AHalf Life of Folic Acid + L-CarnitineN/ASide Effects of Folic Acid + L-CarnitineN/AContra-indications of Folic Acid + L-CarnitineN/ASpecial Precautions while taking Folic Acid + L-CarnitineN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid + L-CarnitineN/AInteractions for Folic Acid + L-CarnitineN/ATypical Dosage for Folic Acid + L-CarnitineN/ASchedule of Folic Acid + L-CarnitineN/AStorage Requirements for Folic Acid + L-CarnitineN/AEffects of Missed Dosage of Folic Acid + L-CarnitineN/AEffects of Overdose of Folic Acid + L-CarnitineN/AFolic Acid
About Folic AcidDietary supplement, Folate derivative( B9 ), Water Soluble Vitamin.Mechanism of Action of Folic AcidFolic acid reduced by enzymes folate reductase and dihydrofolate reductase and forms dihydrofolic acid tetrahydrofolic acid respectively. Tetrahydrofolic acid acts as a coenzyme which mediates a number of one carbon transfer reactions by carrying a methyl group as an adduct. It involves a number of reactions such as 1).conversion of homocysteine to methionine. 2).synthesis of thymidylate which is an essential constituent of DNA from methylene-tetrahydrofolic acid. 3). Conversion of serine to glycine by tetrahydrofolic acid and forms methylene-tetrahydrofolic acid. 4).to introduce carbon units at position 2 and 8 during de novo purine synthesis requires formyl-tetrahydrofolic acid and methenyl-tetrahydrofolic acid.5).generation and utilization of "formate pool". 6).For mediating formino group transfer in histidine metabolism. Folic acid is required to maintain normal erythropoiesis and nucleoprotein synthesis.Pharmacokinets of Folic AcidAbsorption: Well absorbed orally
Distribution: Widely distributed in the body and highest concentration is seen in liver. It appears in the CSF and breast milk
Metabolism: Metabolized in to N-methyl tetrahydrofolic acid in liver
Excretion: Extra drug is excreted unchanged in urine. A small portion of folate is lost by a combination of urinary and fecal excretion and oxidative cleavage of molecule.
Onset of Action for Folic AcidOral: 20 to 30minutes
I.V.: 5 minutes
I.M.:10 to 20minutes
Duration of Action for Folic AcidOral: 3 to 6 hours
I.V.:3 to 6minutes
I.M.:3 to 6hours
Half Life of Folic AcidN/ASide Effects of Folic AcidN/AContra-indications of Folic AcidN/ASpecial Precautions while taking Folic Acid1. In patients with undiagnosed anaemia; because it may mask pernicious anaemia
2. In pernicious anaemia and other megaloblastic where vitamin B12 is deficient
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Folic Acid1. Megaloblastic anaemia
2. Folic acid deficiency
3. Anaemias of pregnancy
4. Nutritional anaemia
5. Alcoholism
6. Tropical sprue
7. Non tropical sprue
Interactions for Folic Acid1. Hypersensitivity reactions with injection form
2. Bronchospasm
Typical Dosage for Folic AcidOral: 5mg 1 to 4 times daily; depending up on the severity of deficiency.
Maintenance dosage: Half of the therapeutic dosage.
Children: 2.5 to 5mg 1 to 2 times daily.
Schedule of Folic AcidC1 (Oral)
C (Parenteral)
Storage Requirements for Folic AcidStore at controlled room temperature at a range of 15 to 25 degree C in a well closed container. Protect from excess heat, light and moisture.Effects of Missed Dosage of Folic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Folic AcidRelatively non toxic. Provide symptomatic treatment and supportive measures.L-carnitine
About L-carnitineDietary supplement, Amino acid derivative, Antioxidant.Mechanism of Action of L-carnitineCarnitine is an essential co-factor of fatty acid metabolism in the heart, liver, and skeletal muscle. It is normally synthesised in the liver, brain, and kidneys in sufficient quantities to meet human requirements. It is an antioxidant. It protects neurons from damage caused by super oxide radicals.Pharmacokinets of L-carnitineLevocarnitine is absorbed slowly and incompletely from the small intestine. Distribution: It is distributed mainly in free form. Metabolism: It undergoes minimal metabolism. Excretion: It is excreted mainly in urine and small amount through faeces.Onset of Action for L-carnitineN/ADuration of Action for L-carnitineN/AHalf Life of L-carnitineN/ASide Effects of L-carnitine1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal cramps
Contra-indications of L-carnitineN/ASpecial Precautions while taking L-carnitine1.Severe renal impairment
2.Diabetic patients
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for L-carnitine1.As antioxidant
2.Carnitine deficiency
Interactions for L-carnitineN/ATypical Dosage for L-carnitineOral
Adult: 100 - 200 mg/kg daily in 2 to 4 divided doses.
Children: 50 to 100 mg/kg daily in 2 to 4 divided doses
Parenteral (IV)
Adult: 50 to 100 mg/kg daily is given in 3 to 4 divided doses by slow intravenous injection over 2 to 3 minutes.
Schedule of L-carnitineHStorage Requirements for L-carnitineN/AEffects of Missed Dosage of L-carnitineN/AEffects of Overdose of L-carnitineN/AHome Delivery for Folic Acid + L-Carnitine in Your City
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