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- Pharmacology For Etoricoxib + Serratiopeptidase
Etoricoxib + Serratiopeptidase Pharmacology
Etoricoxib + Serratiopeptidase
About Etoricoxib + SerratiopeptidaseN/AMechanism of Action of Etoricoxib + SerratiopeptidaseN/APharmacokinets of Etoricoxib + SerratiopeptidaseN/AOnset of Action for Etoricoxib + SerratiopeptidaseN/ADuration of Action for Etoricoxib + SerratiopeptidaseN/AHalf Life of Etoricoxib + SerratiopeptidaseN/ASide Effects of Etoricoxib + SerratiopeptidaseN/AContra-indications of Etoricoxib + SerratiopeptidaseN/ASpecial Precautions while taking Etoricoxib + SerratiopeptidaseN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Etoricoxib + Serratiopeptidase1.Osteoarthritis
2.Rheumatoid arthritis
3.Acute gout
Interactions for Etoricoxib + SerratiopeptidaseN/ATypical Dosage for Etoricoxib + SerratiopeptidaseN/ASchedule of Etoricoxib + SerratiopeptidaseN/AStorage Requirements for Etoricoxib + SerratiopeptidaseN/AEffects of Missed Dosage of Etoricoxib + SerratiopeptidaseN/AEffects of Overdose of Etoricoxib + SerratiopeptidaseN/AEtoricoxib
About EtoricoxibNSAID, selective COX-2 inhibitor, Analgesic,Anti-inflammatory,Antiarthritic.Mechanism of Action of EtoricoxibThis NSAID is a selective COX2 inhibitor (blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in producing prostaglandins, in response to injury or certain diseases. These prostaglandins cause pain, swelling and inflammation). This inhibition results the analgesics and anti-inflammatory action peripherallyPharmacokinets of EtoricoxibAbsorption- Well absorbed after administration
Distribution- Widely distributed in the body
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted through urine and feces
Onset of Action for Etoricoxib24 minDuration of Action for Etoricoxib24 hrsHalf Life of EtoricoxibIts plasma half life is 22 hrsSide Effects of Etoricoxib1. Dry mouth
2. Taste disturbances
3. Mouth ulcers
4. Flatulence
5. Constipation
6. Appetite and weight changes
7. Chest pain
8. Fatigue
9. Paresthesia
10. Myalgia
11. Rash
12. Blurred vision
13. Insomnia
14. Muscle cramps
15. Ulceration of the stomach or intestine
16. Cold or flu-like symptoms
17. Dizziness
18. Excessive fluid retention in the body tissues, resulting in swelling (oedema)
19. Epistaxis
20. Difficulty in breathing (dyspnoea)
21. Weakness or loss of strength (asthenia)
22. High blood pressure (hypertension)
23. Anxiety
24. Headache
Contra-indications of Etoricoxib1. Hypersensitivity to the drug
2. Hyper sensitivity to other NSAID
3. Active peptic ulceration
4. Inflammatory bowel disease
5. Severe congestive heart failureSpecial Precautions while taking Etoricoxib1. Allergic disorders
2. Renal impairment
3. Cardiac diseases
4. Hepatic impairmentPregnancy Related InformationContraindicated
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Etoricoxib1. Rheumatoid Arthritis
2. Osteoarthritis
3. Acute gouty ArthritisInteractions for EtoricoxibAnticoagulants : May prolong prothrombin time. Instruct patients to watch for signs & symptoms of bleeding.
ACE inhibitors : Antihypertensive effects of captopril may be blunted or completely abolished by etoricoxib.
b-Blockers : Antihypertensive effect may be blunted.
Cyclosporine : Nephrotoxicity of both agents may be increased.
Digoxin : Serum digoxin levels may be increased by ibuprofen and etoricoxib.
Hydantoins : Serum hydantoin levels increased resulting in increased pharmacological and toxic effects.
Lithium : Serum lithium levels may be increased.
Loop diuretics : Decreased effects.
Methotrexate : Risk of methotrexate toxicity (bone marrow suppression, nephrotoxicity, stomatitis) may be increased.
Salicylates : displaces NSAIDs from serum binding sites resulting in decreased plasma concentrations of NSAIDs and increased incidence of GI effects.
Sympathomimetics : Rofecoxib coadministration may result in increased blood pressure.
Thiazide diuretics : Naproxen and etoricoxib may cause decreased antihypertensive and diuretic action.Typical Dosage for EtoricoxibOral- Adults-
Osteoarthritis- 60 mg once daily
Rheumatoid Arthritis- 90 mg once daily
Acute gouty Arthritis-120 mg once daily
Schedule of EtoricoxibN/AStorage Requirements for EtoricoxibStore at room temperature away from moisture and heatEffects of Missed Dosage of EtoricoxibTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of EtoricoxibGive symptomatic and supportive treatment. Induce gastric emesis and administer activated charcoal to reduce further adsorption of drugs.
Serratiopeptidase
About SerratiopeptidaseA proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.Mechanism of Action of SerratiopeptidaseThis anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.Pharmacokinets of SerratiopeptidaseOrally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.Onset of Action for SerratiopeptidaseN/ADuration of Action for Serratiopeptidase8 to 10 hrsHalf Life of SerratiopeptidaseN/ASide Effects of Serratiopeptidase1. Hypersensitivity
2. Anorexia
3. Gastric discomfort
4. Nausea
5. Vomiting
6. Epistaxis
7. Diarrhoea
8. Skin rash
Contra-indications of Serratiopeptidase1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase1. In patients with renal failure or hepatic failurePregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Serratiopeptidase1. Antiinflammatory
2. Antiswelling
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
6. Bronchitis
7. Fibrocystic breast swelling
8. Sinusitis
9. Cough
10. Laryngitis
11. Fibromyalgia
12. Emphysema
13. Gout
Interactions for SerratiopeptidaseN/ATypical Dosage for SerratiopeptidaseOral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of SerratiopeptidaseN/AStorage Requirements for SerratiopeptidaseStore below 25 degree Celsius, protect from light and moisture.Effects of Missed Dosage of SerratiopeptidaseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SerratiopeptidaseGive supportive measures and symptomatic treatment.Home Delivery for Etoricoxib + Serratiopeptidase in Your City
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Etoricoxib + Serratiopeptidase is a generic medicine name and there are several brands available for it. Some of the brands for etoricoxib + serratiopeptidase might be better known than etoricoxib + serratiopeptidase itself. If the pharmacy that's willing to deliver medicines to your home doesn't have etoricoxib + serratiopeptidase in stock, you can ask for one of the branded alternatives for etoricoxib + serratiopeptidase.