Cefotaxime Pharmacology

Cefotaxime

About Cefotaxime
Third Generation cephalosporin Parenteral antibiotic.
Mechanism of Action of Cefotaxime
Cefotaxime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. Cefotaxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefotaxime
Pharmacokinets of Cefotaxime
Absorption: Orally not well absorbed & should be given parenterally, Distribution: widely distributed, & good CSF penetration, Metabolism: A portion of it is deacetylated in the body in to an active metabolite desacetylcefotaxime, Excretion: Excreted mainly through urine & small amount is seen in breast milk.

Onset of Action for Cefotaxime
Sudden
Duration of Action for Cefotaxime
12 hours
Half Life of Cefotaxime
N/A
Side Effects of Cefotaxime
1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes
3.Vaginitis
4.Pruritus
5.Candidiasis
6.Nephrotoxicity
7.Pseudo membranous colitis
8.Nausea
9.Vomiting
10.Elevated liver enzymes
11.Neutropenia
12.Thrombocytopenia
Contra-indications of Cefotaxime
1.Hypersensitivity to cephalosporins
2.Along with other nephrotoxic drugs
3.Pseudo membranous colitis
Special Precautions while taking Cefotaxime
1.Renal impairment
2.Patient allergic to penicillins
3.Neuromuscular disorders
Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution..
Children Related Information
May be used.
Neonates: may be used
Indications for Cefotaxime
1.Meningitis
2.Resistant hospital acquired infections
3.Septicemia
4.Infections in immunocompromised patients
5.Urinary tract &genital tract infections
6.Surgical prophylaxis
7.Skin & soft tissue infections
8.Bone & Joint infections
9.Gonorrhea.
Interactions for Cefotaxime
Synergy with aminoglycosides.
Typical Dosage for Cefotaxime
Adults: 1g to 2gm I.M. or I.V. two times daily to four times daily.
Children: 50 to 100 mg/kg/day I.M or I.V. two times daily to four times daily.
Neonates: 50mg/kg I.V. two times daily in first week & three times daily in next three weeks
Maximum adult dose: Up to 12gm/day
Maximum child dose: 200mg/kg/day three times daily or four times daily
Gonorrhea: 1gm, once daily, I.M.
Schedule of Cefotaxime
H
Storage Requirements for Cefotaxime
Store in a refrigerator.
Effects of Missed Dosage of Cefotaxime
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefotaxime
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures

Home Delivery for Cefotaxime in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cefotaxime.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefotaxime and other medicines and health products. Home delivery services for cefotaxime may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefotaxime only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefotaxime before they complete the sale. You can get this information while placing the order for cefotaxime with the pharmacy.

Cefotaxime is a generic medicine name and there are several brands available for it. Some of the brands for cefotaxime might be better known than cefotaxime itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefotaxime in stock, you can ask for one of the branded alternatives for cefotaxime.