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- Pharmacology For Cefuroxime + Serratiopeptidase
Cefuroxime + Serratiopeptidase Pharmacology
Cefuroxime + Serratiopeptidase
About Cefuroxime + SerratiopeptidaseN/AMechanism of Action of Cefuroxime + SerratiopeptidaseN/APharmacokinets of Cefuroxime + SerratiopeptidaseN/AOnset of Action for Cefuroxime + SerratiopeptidaseN/ADuration of Action for Cefuroxime + SerratiopeptidaseN/AHalf Life of Cefuroxime + SerratiopeptidaseN/ASide Effects of Cefuroxime + SerratiopeptidaseN/AContra-indications of Cefuroxime + SerratiopeptidaseN/ASpecial Precautions while taking Cefuroxime + SerratiopeptidaseN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Cefuroxime + SerratiopeptidaseN/AInteractions for Cefuroxime + SerratiopeptidaseN/ATypical Dosage for Cefuroxime + SerratiopeptidaseN/ASchedule of Cefuroxime + SerratiopeptidaseN/AStorage Requirements for Cefuroxime + SerratiopeptidaseN/AEffects of Missed Dosage of Cefuroxime + SerratiopeptidaseN/AEffects of Overdose of Cefuroxime + SerratiopeptidaseN/ACefuroxime
About CefuroximeSecond Generation Cephalosporin antibiotic.Mechanism of Action of CefuroximeCefuroxime is a 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefuroxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefuroxime
Pharmacokinets of CefuroximeCefuroxime sodium is orally not well absorbed & should be given parenterally but Cefuroxime axetil is absorbed orally & food increases absorption rate. Distribution: widely distributed, & greater CSF penetration. Metabolism: Not metabolized, Excretion: Excreted mainly through urine & small amount is seen in breast milk.Onset of Action for CefuroximeWithin 1 hourDuration of Action for Cefuroxime12 hoursHalf Life of CefuroximeN/ASide Effects of Cefuroxime1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2.Rashes & allergic manifestations
3.Vaginitis
4.Nephrotoxicity
5.Pseudo membranous colitis
6.Pruritus
7.Candidiasis
8.Glossitis
9.Nausea
10.Vomiting
11.Elevated liver enzymes
12.Neutropenia
13.Thrombocytopenia
14.Hemolytic anemia
Contra-indications of Cefuroxime1.Hypersensitivity to Cefuroxime or other cephalosporins
2.Along with other nephrotoxic drugs
3.Along with oral anticoagulants
4.Pseudo membranous colitis
Special Precautions while taking Cefuroxime1.Pseudomembranous colitis
2.Patients sensitive to PenicillinPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Cefuroxime1.Meningitis caused by H.influenzae, meningococci, pneumococci etc.
2.Gonorrhea
3.Pneumonia & Pulmonary infections
4.Infections caused by ampicillin resistant H. influenzae
5.Septicemia
6.Tonsillitis
7.Pharyngitis
8.Urinary tract infections
9.Otitis media
Interactions for CefuroximeSynergy with aminoglycosides.Typical Dosage for CefuroximeAdults:
Oral dose: 0.25 to 0.5gm two times daily
Parenteral dose: 0.75 to 1.5gm I.M or I.V. thrice daily for 5 to 10 days.
Severe infections: 1.5gm I.M. or I.V. four times daily
Meningitis: 3gm I.M.or I.V. thrice daily
Tonsillitis, Pharyngitis, Urinary tract infections etc.: 125 to 500mg orally twice daily up to 10 days
Children:30 to 100mg/kg/day I.M or I.V. three times daily or four times daily
Meningitis: Initially 200 to 240mg/kg/day I.V. three times daily or four times daily & continue the therapy with 100mg/kg/day.
Tonsillitis, Pharyngitis, Urinary tract infections etc.:
Above 1`2 years:same as adult dose
Below 12 years: 0.125gm to 0.25gm orally twice daily for 10 days or :20mg/kg/day oral suspension twice daily for 10 days
Otitismedia: 30mg/kg/day orally twice daily
Schedule of CefuroximeHStorage Requirements for CefuroximeStore in a cool place.Effects of Missed Dosage of CefuroximeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CefuroximeSymptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures.Serratiopeptidase
About SerratiopeptidaseA proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.Mechanism of Action of SerratiopeptidaseThis anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.Pharmacokinets of SerratiopeptidaseOrally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.Onset of Action for SerratiopeptidaseN/ADuration of Action for Serratiopeptidase8 to 10 hrsHalf Life of SerratiopeptidaseN/ASide Effects of Serratiopeptidase1. Hypersensitivity
2. Anorexia
3. Gastric discomfort
4. Nausea
5. Vomiting
6. Epistaxis
7. Diarrhoea
8. Skin rash
Contra-indications of Serratiopeptidase1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase1. In patients with renal failure or hepatic failurePregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Serratiopeptidase1. Antiinflammatory
2. Antiswelling
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
6. Bronchitis
7. Fibrocystic breast swelling
8. Sinusitis
9. Cough
10. Laryngitis
11. Fibromyalgia
12. Emphysema
13. Gout
Interactions for SerratiopeptidaseN/ATypical Dosage for SerratiopeptidaseOral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of SerratiopeptidaseN/AStorage Requirements for SerratiopeptidaseStore below 25 degree Celsius, protect from light and moisture.Effects of Missed Dosage of SerratiopeptidaseTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SerratiopeptidaseGive supportive measures and symptomatic treatment.Home Delivery for Cefuroxime + Serratiopeptidase in Your City
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Cefuroxime + Serratiopeptidase is a generic medicine name and there are several brands available for it. Some of the brands for cefuroxime + serratiopeptidase might be better known than cefuroxime + serratiopeptidase itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefuroxime + serratiopeptidase in stock, you can ask for one of the branded alternatives for cefuroxime + serratiopeptidase.