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- Pharmacology For Naproxen + Paracetamol
Naproxen + Paracetamol Pharmacology
Naproxen + Paracetamol
About Naproxen + ParacetamolN/AMechanism of Action of Naproxen + ParacetamolN/APharmacokinets of Naproxen + ParacetamolN/AOnset of Action for Naproxen + ParacetamolN/ADuration of Action for Naproxen + ParacetamolN/AHalf Life of Naproxen + ParacetamolN/ASide Effects of Naproxen + ParacetamolN/AContra-indications of Naproxen + ParacetamolN/ASpecial Precautions while taking Naproxen + ParacetamolN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Naproxen + Paracetamol1.Rheumatic disorders
2.Acute musculoskeletal disorders
3.Migrain
4.Acute gout
Interactions for Naproxen + ParacetamolN/ATypical Dosage for Naproxen + ParacetamolN/ASchedule of Naproxen + ParacetamolN/AStorage Requirements for Naproxen + ParacetamolN/AEffects of Missed Dosage of Naproxen + ParacetamolN/AEffects of Overdose of Naproxen + ParacetamolN/ANaproxen
About NaproxenNSAID, 2-arylpropionic acid (profen) derivative, Analgesic, anti-inflammatory,antipyretic.Mechanism of Action of NaproxenNaproxen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Naproxen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.Pharmacokinets of NaproxenAbsorption: Naproxen is well absorbed after oral administration and its bioavailability is about 95 %.
Distribution: It is distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver.
Excretion: Naproxen and its metabolites are excreted mainly in the urine.
Onset of Action for Naproxen1 hoursDuration of Action for Naproxen7 hoursHalf Life of Naproxen10-20 hoursSide Effects of Naproxen1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastrointestinal bleeding
5. Abdominal pain
6. Constipation
7. Peptic ulceration
8. Dyspepsia
9. Headache
10. Drowsiness
11. Oedema
12. Agranulocytosis
13. Neutropenia
14. Thrombocytopenia
15. Dizziness
16. Rash
17. Pruritis
Contra-indications of Naproxen1. Hypersensitivity to Naproxen and other NSAIDs
2. Inflammatory bowel disease
3. Peptic ulcer
4. Severe renal impairment
Special Precautions while taking Naproxen1. Hepatic impairment
2. Renal impairment
3. Hypertension
4. Gastrointestinal diseases
5. Pre existing asthma
6. Oedema
7. Heart failure
8. Myocardial infarction
9. Stroke
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
NEONATES: ContraindicatedIndications for Naproxen1. Rheumatoid arthritis
2. Ankylosing spondylitis
3. Acute gout
4. Joint disorders e.g. inflammatory disease and crystal deposition in the joints
5. Osteoarthritis
6. For the relief of pain and inflammation in dental minor surgery and orthopedic
7. Dysmenorrhoea
8. Juvenile arthritis
9. Migraine
Interactions for NaproxenN/ATypical Dosage for NaproxenAdult: 500 - 1 g / day in 2 divided doses
Pain, Migraine, Dysmenorrhoea, Tendonitis, and Bursitis: Initial dose: 500 mg followed by 250 mg every 6 - 8 hours.
Maximum daily dose after first day: 1250mg
Acute gout: Initial dose: 750 mg followed by 250 mg every 8 hours until attack has subsided.
Children: 5 mg / kg body weight 2 times daily
Schedule of NaproxenHStorage Requirements for NaproxenStore Naproxen at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of NaproxenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NaproxenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Paracetamol
About ParacetamolAcetanilide derivative, Non narcotic Analgesic,Antipyretic.Mechanism of Action of ParacetamolParacetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of ParacetamolAbsorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol30 - 60 minutesDuration of Action for Paracetamol6 hoursHalf Life of Paracetamol1-4 hoursSide Effects of Paracetamol1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol1. Hypersensitivity to ParacetamolSpecial Precautions while taking Paracetamol1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES : Contraindicated
Indications for Paracetamol1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for ParacetamolCholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.Typical Dosage for ParacetamolAdult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of ParacetamolHStorage Requirements for ParacetamolStore at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.Effects of Missed Dosage of ParacetamolTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ParacetamolGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Naproxen + Paracetamol in Your City
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Naproxen + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for naproxen + paracetamol might be better known than naproxen + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have naproxen + paracetamol in stock, you can ask for one of the branded alternatives for naproxen + paracetamol.