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- Pharmacology For Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6
Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6 Pharmacology
Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6
About Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/AMechanism of Action of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/APharmacokinets of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/AOnset of Action for Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/ADuration of Action for Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/AHalf Life of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/ASide Effects of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/AContra-indications of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/ASpecial Precautions while taking Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B61.Peripheral neuropathies
2.Diabetic neuropathy
3.Nutritional supplement
Interactions for Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/ATypical Dosage for Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/ASchedule of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/AStorage Requirements for Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/AEffects of Missed Dosage of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/AEffects of Overdose of Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6N/ABenfotiamine
About BenfotiamineSynthetic S-acyl derivative of thiamine (vitamine B1), Antioxidant ,anti-AGE(Advanced glycation end product) supplement, Treating Diabetic Complications.Mechanism of Action of BenfotiamineN/APharmacokinets of BenfotiamineN/AOnset of Action for BenfotiamineN/ADuration of Action for BenfotiamineN/AHalf Life of BenfotiamineN/ASide Effects of BenfotiamineN/AContra-indications of BenfotiamineN/ASpecial Precautions while taking BenfotiamineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Benfotiamine1.Management of diabetic neuropathy, diabetic nephropathy and diabetic retinopathy
2.Beri Beri
3.Wenicke-korsakoff syndrome
Interactions for BenfotiamineN/ATypical Dosage for BenfotiamineN/ASchedule of BenfotiamineN/AStorage Requirements for BenfotiamineN/AEffects of Missed Dosage of BenfotiamineN/AEffects of Overdose of BenfotiamineN/AMecobalamin
About MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
2.Megaloblastic anaemia
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/AAlpha-Lipoic acid
About Alpha-Lipoic acidNaturally occurring dithiol compound , antioxidant, Agent for neuropathies.Mechanism of Action of Alpha-Lipoic acidAlpha-lipoic acid and its reduced metabolite, Dihydrolipoic acid (DHLA), form a redox couple and may scavenge a wide range of reactive oxygen species. Alpha-lipoic acid has been found to decrease urinary isoprostanes, O-LDL and plasma protein carbonyls, markers of oxidative stress. Further, alpha-lipoic acid and its redox couple DHLA have been found to have antioxidant activity in aqueous, as well as in lipophilic regions, and in extra cellular and intracellular environments. Alpha-lipoic acid participates in the recycling of other important biologic antioxidants, such as vitamins E and C, Ubiquinone and glutathione.
Both alpha-lipoic acid and DHLA can scavenge hydroxyl radicals, the nitric oxide radical, peroxynitrite, hydrogen peroxide and hypochlorite. Alpha-lipoic acid may scavenge singlet oxygen, and DHLA may scavenge super oxide and peroxyl reactive oxygen species.
Pharmacokinets of Alpha-Lipoic acidAbsorption: Alpha-lipoic acid is absorbed from the small intestine. The natural R-entantiomer is more readily absorbed than the L-entantiomer and is the more active form.
Distribution:It is distributed to the liver via the portal circulation and to various tissues in the body via the systemic circulation. . Alpha-lipoic acid readily crosses the blood-brain barrier. It is found, after its distribution to the various body tissues, intracellularly, intramitochondrialy and extracellularly.Metabolism: Alpha-lipoic acid is metabolized to its reduced form, dihydrolipoic acid (DHLA), by mitochondrial lipoamide dehydrogenase enzyme. DHLA, together with lipoic acid, form a redox couple. It is also metabolized to lipoamide, which functions as the lipoic acid cofactor in the multienzyme complexes that catalyze the oxidative decarboxylations of pyruvate and alpha-ketoglutarate. Alpha-lipoic acid may be metabolized to dithiol octanoic acid, which can undergo catabolism.
Onset of Action for Alpha-Lipoic acidN/ADuration of Action for Alpha-Lipoic acidN/AHalf Life of Alpha-Lipoic acidN/ASide Effects of Alpha-Lipoic acid1.Nausea
2.VomitingContra-indications of Alpha-Lipoic acid1.Contraindicated during radiotherapySpecial Precautions while taking Alpha-Lipoic acidPatient with diabetes and problems with glucose intolerancePregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Alpha-Lipoic acid1.Diabetic neuropathy
2.It may help prevent the oxidation of LDL cholesterol and may be protective, generally, against oxidative stress and, specifically, against atherosclerosis, ischemia-reperfusion injury and various radiologic and chemical toxins.
3.It may also be useful in some inborn metabolic disordersInteractions for Alpha-Lipoic acidN/ATypical Dosage for Alpha-Lipoic acidAdult: up to 600 milligrams daily
Diabetic neuropathy: 300 milligrams daily taken in divided doses.Schedule of Alpha-Lipoic acidN/AStorage Requirements for Alpha-Lipoic acidStore at room temperature away from moisture and heat.Keep out of the reach of children. Keep the medicine from freezing. Do not refrigerate.Effects of Missed Dosage of Alpha-Lipoic acidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.Effects of Overdose of Alpha-Lipoic acidGive supportive measures and symptomatic treatment.Vit B6
About Vit B6Physiological functions: It is involved as a coenzyme (Pyridoxal phosphate) in metabolism of tryptophan, in several metabolic transformations of amino acids including transamination, decarboxylation & racemization.
Deficiency symptoms: Peripheral neuritis, seizures, stomatitis, glossitis, anaemia, seborrhea like lesions.Mechanism of Action of Vit B6Vitamin B6 is a collective term for Pyridoxine, Pyridoxal, Pyridoxamine and their phosphorylated derivatives such as Pyridoxine phosphate, Pyridoxal phosphate and Pyridoxamine derivatives respectively. Vitamin B6 is essential for the metabolism of amino acid, glycogen and fatty acids, for nerve functions, for the formation of red blood cells and also helps the skin healthy. Vitamin B6 is also used for the synthesis of nucleic acid, Haemoglobin, Sphingomyelin, other Sphingolipids, Serotonin, Dopamine, Noradrenaline and GABA.Pharmacokinets of Vit B6Absorption: Vitamin B6 is readily absorbed after oral administration.
Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain.
Metabolism: It is metabolised in the liver
Onset of Action for Vit B6N/ADuration of Action for Vit B6N/AHalf Life of Vit B615-20 daysSide Effects of Vit B61. Neuropathy
2. Unstable gait
3. Drowsiness
4. Perioral numbness
5. Paresthesia
6. Numbness of feet
7. Somnolence
8. Sensory neuropathy
9. Ataxia
Contra-indications of Vit B61. Hypersensitivity to Vitamin B6Special Precautions while taking Vit B6N/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Contraindicated
Indications for Vit B61. Vitamin B6 deficiency including inadequate diet and drug induced causes
2. Neuropathy
3. Premenstrual syndrome
4. Hyperoxaluria type 1
5. Metabolic disorder
6. Isoniazid poisoning
Interactions for Vit B6Cycloserine, Hydralazine, Isoniazide, Oral contraceptive, Penicillamine: Increase Pyridoxine requirement.
Levodopa: Pyridoxine reverses the therapeutic effect of Levodopa.
Phenobarbital, Phenytoin: Pyridoxine decreases serum level of these anticonvulsants.
Typical Dosage for Vit B6Adult: 10 - 20 mg / day
Dietary deficiency: 2.5 -10 mg / day for effective therapeutic response is obtained.
Maintenance dose: 2 - 5 mg / day for several weeks.
Drug induced deficiency: 100 - 200 mg / day for 3 weeks.
Maintenance dose: 25 - 100 mg / day
Neuropathy: 50 - 200 mg /day
Premenstrual syndrome: 40 - 500 mg / day
Hyperoxaluria type 1: 25 - 300 mg / day
Metabolic disorder: 100-500 mg /day.
Isoniazid poisoning: Initial dose: 1 - 4 g as IV administration, then 1 g IM every 30 minute until Pyridoxine dose is equal to the Isoniazid dose has been given.
Schedule of Vit B6N/AStorage Requirements for Vit B6Store it at 15 - 30 degree C. Protect from moisture and heat.Effects of Missed Dosage of Vit B6Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B6Give supportive measures and symptomatic treatment. The signs of Pyridoxine overdose can be resolved by discontinuation (withdrawal) of Pyridoxine.Home Delivery for Benfotiamine + Mecobalamin + Alpha-Lipoic Acid + Vit B6 in Your City
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