Duloxetine + Mecobalamin Pharmacology

Duloxetine + Mecobalamin

About Duloxetine + Mecobalamin

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Mechanism of Action of Duloxetine + Mecobalamin

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Pharmacokinets of Duloxetine + Mecobalamin

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Onset of Action for Duloxetine + Mecobalamin

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Duration of Action for Duloxetine + Mecobalamin

N/A

Half Life of Duloxetine + Mecobalamin

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Side Effects of Duloxetine + Mecobalamin

N/A

Contra-indications of Duloxetine + Mecobalamin

N/A

Special Precautions while taking Duloxetine + Mecobalamin

N/A

Pregnancy Related Information

Contraindicated

Old Age Related Information

N/A

Breast Feeding Related Information

Contraindicated

Children Related Information

N/A

Indications for Duloxetine + Mecobalamin

1.Management of neuropathic pain associated with diabetic peripheral neuropathy, and fibromyalgia
2.Depression

Interactions for Duloxetine + Mecobalamin

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Typical Dosage for Duloxetine + Mecobalamin

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Schedule of Duloxetine + Mecobalamin

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Storage Requirements for Duloxetine + Mecobalamin

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Effects of Missed Dosage of Duloxetine + Mecobalamin

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Effects of Overdose of Duloxetine + Mecobalamin

N/A

Duloxetine

About Duloxetine

A serotonin-norepinephrine reuptake inhibitor,Thiophene derivative, Antidepressant.

Mechanism of Action of Duloxetine

Duloxetine preferentially inhibits the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitter Serotonin in the synaptic cleft and produces antidepressant effect

Pharmacokinets of Duloxetine

Absorption: It is well absorbed after oral administration. Distribution: It is very widely distributed in the body in protein bound form. Metabolism: Duloxetine is extensively metabolised in the liver. Excretion: Excreted mainly through urine and small amount excreted through urine.

Onset of Action for Duloxetine

N/A

Duration of Action for Duloxetine

N/A

Half Life of Duloxetine

12 hours

Side Effects of Duloxetine

1.Diarrhea
2.Vomiting
3.Nausea
4.Dry mouth
5.Constipation
6.Decreased appetite
7.Decreased weight
8.Fatigue
9.Dizziness
10.Somnolence
11.Tremor
12.Sweating increased
13.Hot flushes
14.Blurred Vision
15.Insomnia
16.Anxiety
17.Ejaculatory dysfunction

Contra-indications of Duloxetine

1.Hypersensitivity to Duloxetine
2.Patient on Monoamine Oxidase Inhibitors therapy
3.Uncontrolled Narrow-Angle Glaucoma
4.Severe hepatic impairment
5.Hypertension

Special Precautions while taking Duloxetine

1.Bipolar affective disorder
2.History of mania
3.Epilepsy
4.Heart disease
5.People with bleeding tendencies

Pregnancy Related Information

contraindicated

Old Age Related Information

use with caution

Breast Feeding Related Information

contraindicated

Children Related Information

contraindicated

Indications for Duloxetine

1. Major depressive disorder
2. Diabetic Peripheral Neuropathic Pain
3. Generalised anxiety disorder

Interactions for Duloxetine

N/A

Typical Dosage for Duloxetine

Major Depressive Disorder: 20 - 60mg / day in 2 divided doses
Diabetic Peripheral Neuropathic Pain:60 mg/day
Generalized Anxiety Disorder: 60 mg/ day

Schedule of Duloxetine

N/A

Storage Requirements for Duloxetine

Store at 15 - 25 degree C. Keep out of the reach of children.

Effects of Missed Dosage of Duloxetine

Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.

Effects of Overdose of Duloxetine

Give supportive measures and symptomatic treatment. Gastric lavage can be done to eliminate the drug from the body. Charcoal can be given to reduce the absorption of the drug.

Mecobalamin

About Mecobalamin

Water soluble, Form of Vitamin B12

Mechanism of Action of Mecobalamin

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Pharmacokinets of Mecobalamin

Absorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine

Onset of Action for Mecobalamin

N/A

Duration of Action for Mecobalamin

N/A

Half Life of Mecobalamin

N/A

Side Effects of Mecobalamin

1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site

Contra-indications of Mecobalamin

N/A

Special Precautions while taking Mecobalamin

N/A

Pregnancy Related Information

May be used

Old Age Related Information

May be used

Breast Feeding Related Information

May be used

Children Related Information

N/A

Indications for Mecobalamin

1.Peripheral neuropathies
2.Megaloblastic anaemia

Interactions for Mecobalamin

1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol

Typical Dosage for Mecobalamin

Peripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk

Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.

Schedule of Mecobalamin

N/A

Storage Requirements for Mecobalamin

Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.

Effects of Missed Dosage of Mecobalamin

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Effects of Overdose of Mecobalamin

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Home Delivery for Duloxetine + Mecobalamin in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for duloxetine + mecobalamin and other medicines and health products. Home delivery services for duloxetine + mecobalamin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take duloxetine + mecobalamin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for duloxetine + mecobalamin before they complete the sale. You can get this information while placing the order for duloxetine + mecobalamin with the pharmacy.

Duloxetine + Mecobalamin is a generic medicine name and there are several brands available for it. Some of the brands for duloxetine + mecobalamin might be better known than duloxetine + mecobalamin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have duloxetine + mecobalamin in stock, you can ask for one of the branded alternatives for duloxetine + mecobalamin.