Cefadroxil + Ambroxol Pharmacology

Cefadroxil + Ambroxol

About Cefadroxil + Ambroxol
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Mechanism of Action of Cefadroxil + Ambroxol
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Pharmacokinets of Cefadroxil + Ambroxol
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Onset of Action for Cefadroxil + Ambroxol
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Duration of Action for Cefadroxil + Ambroxol
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Half Life of Cefadroxil + Ambroxol
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Side Effects of Cefadroxil + Ambroxol
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Contra-indications of Cefadroxil + Ambroxol
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Special Precautions while taking Cefadroxil + Ambroxol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Cefadroxil + Ambroxol
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Interactions for Cefadroxil + Ambroxol
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Typical Dosage for Cefadroxil + Ambroxol
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Schedule of Cefadroxil + Ambroxol
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Storage Requirements for Cefadroxil + Ambroxol
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Effects of Missed Dosage of Cefadroxil + Ambroxol
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Effects of Overdose of Cefadroxil + Ambroxol
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Cefadroxil

About Cefadroxil
First Generation Cephalosporin, para-hydroxy derivative of cefalexin, Oral broad-spectrum antibiotic
Mechanism of Action of Cefadroxil
Cefadroxil is a 1st generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefadroxil inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefadroxil

Pharmacokinets of Cefadroxil
Absorption: well absorbed orally, Distribution: widely distributed, Metabolism: not metabolized, Excretion: excreted mainly through urine; & small amount is excreted in breast milk.
Onset of Action for Cefadroxil
Within one hour
Duration of Action for Cefadroxil
Up to16 hours
Half Life of Cefadroxil
N/A
Side Effects of Cefadroxil
1.Nausea
2.Vomiting
3.Diarrhea
4.Gastritis
5.Super infection
6.Candidiasis
7.Rash
8.Hypersensitivity reactions
9.Angioedema
10.Vaginitis
11.Neutropenia
12.Thrombocytopenia
13.Headache
14.Dizziness
15.Hallucinations
16.Nephritis
17.Elevated liver enzymes.
Contra-indications of Cefadroxil
1.Hypersensitivity to cephalosporins
2.Porphyria
3.Neuromuscular disorders.
Special Precautions while taking Cefadroxil
1.Renal impairment
2.Patient allergic to penicillins
3.Neuromuscular disorders
Pregnancy Related Information
Use with caution.
Old Age Related Information
May be used.
Breast Feeding Related Information
Use with caution.
Children Related Information
May be used.
Indications for Cefadroxil
1. Urinay tract infections
2. Tonsillitis & Pharyngitis
3. Skin &soft tissue infections
4. Otitis media.
Interactions for Cefadroxil
Aminoglycosides (Gentamycin, Tobramycin): Nephrotoxicity of aminoglycosides potentiated.
Oral anticoagulants: Hypoprothrombinaemic effect potentiated, bleeding complications may occur.
Bacteriostatic Agents like Chloramphenicol: Decrease efficacy of Cefadroxil.
Probenecid: Slows tubular excretion and this enhances efficacy.
Frusemide & Ethacrynic Acid: Potentiate Nephrotoxicity of Cefadroxil.
Urine Glucose: False positive with Benedicts solution and Fehlings solution.
Direct Coomb?s Test: False positive.
Urinary 17-Ketosteroid values: Falsely elevated values.

Typical Dosage for Cefadroxil
Adults:500mg to 1gm 12 hourly
Children:30mg/kg/day two times daily
Schedule of Cefadroxil
H
Storage Requirements for Cefadroxil
Store in a cool place.

Effects of Missed Dosage of Cefadroxil
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Cefadroxil
Symptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measures

Ambroxol

About Ambroxol
Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.
Mechanism of Action of Ambroxol
Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.
Pharmacokinets of Ambroxol
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Onset of Action for Ambroxol
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Duration of Action for Ambroxol
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Half Life of Ambroxol
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Side Effects of Ambroxol
1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.
Contra-indications of Ambroxol
Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.
Special Precautions while taking Ambroxol
1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Ambroxol
1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.
Interactions for Ambroxol
N/A
Typical Dosage for Ambroxol
Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily
Schedule of Ambroxol
H
Storage Requirements for Ambroxol
Store in a cool dry place and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Ambroxol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ambroxol
Provide symptomatic treatment and supportive measures.

Home Delivery for Cefadroxil + Ambroxol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cefadroxil + ambroxol and other medicines and health products. Home delivery services for cefadroxil + ambroxol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cefadroxil + ambroxol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cefadroxil + ambroxol before they complete the sale. You can get this information while placing the order for cefadroxil + ambroxol with the pharmacy.

Cefadroxil + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for cefadroxil + ambroxol might be better known than cefadroxil + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefadroxil + ambroxol in stock, you can ask for one of the branded alternatives for cefadroxil + ambroxol.