Moxonidine + Amlodipine Pharmacology

Moxonidine + Amlodipine

About Moxonidine + Amlodipine
N/A
Mechanism of Action of Moxonidine + Amlodipine
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Pharmacokinets of Moxonidine + Amlodipine
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Onset of Action for Moxonidine + Amlodipine
N/A
Duration of Action for Moxonidine + Amlodipine
N/A
Half Life of Moxonidine + Amlodipine
N/A
Side Effects of Moxonidine + Amlodipine
N/A
Contra-indications of Moxonidine + Amlodipine
N/A
Special Precautions while taking Moxonidine + Amlodipine
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Moxonidine + Amlodipine
Hypertension
Interactions for Moxonidine + Amlodipine
N/A
Typical Dosage for Moxonidine + Amlodipine
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Schedule of Moxonidine + Amlodipine
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Storage Requirements for Moxonidine + Amlodipine
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Effects of Missed Dosage of Moxonidine + Amlodipine
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Effects of Overdose of Moxonidine + Amlodipine
N/A

Moxonidine

About Moxonidine
Centrally-acting antihypertensive.
Mechanism of Action of Moxonidine
Moxonidine is a centrally-acting antihypertensive. It acts in the brainstem through stimulation of central imidazoline receptors to reduce sympathetic tone. Moxonidine also has a low affinity for ?2-adrenoceptors.
Pharmacokinets of Moxonidine
Absorption: Absorbed rapidly from the GI tract
Distribution: Plasma protein binding around 7%; present in breast milk
Excretion: Excreted in the urine (78% as unchanged drug)
Onset of Action for Moxonidine
N/A
Duration of Action for Moxonidine
N/A
Half Life of Moxonidine
N/A
Side Effects of Moxonidine
1.Dry mouth
2.Headache
3.Fatigue
4.Dizziness
5.Nausea
6.Sleep disturbances
7.Asthenia
8.Vasodilatation
9.Skin reactions
10.Constipation
11.Depression
12.Anxiety
13.Anorexia
14.Parotid pain
15.Vivid dreams
16.Impotence and loss of libido
17.Urinary retention or incontinence
18.Slight orthostastic hypotension
19.Fluid retention
Contra-indications of Moxonidine
1.Conduction disorders
2.Bradycardia
3.Severe arrhythmias
4.Severe heart failure
5.Severe ischaemic heart disease
6.History of angioedema
7.Severe liver or renal impairment
8.Raynaud's syndrome
9.Intermittent claudication
10.Epilepsy
11.Depression
12.Parkinson's disease
13.Glaucoma
Special Precautions while taking Moxonidine
1.Renal impairment
2.Avoid abrupt withdrawal (if concomitant treatment with ?-blocker has to be stopped, discontinue ?-blocker first, then moxonidine after few days)
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
Contra indicatedaged under 18 years.
Indications for Moxonidine
Hypertension
Interactions for Moxonidine
1.Additive effects with other antihypertensives
2.May increase sedative effects of benzodiazepines
3.Effects may be antagonised by TCAS
Typical Dosage for Moxonidine
Hypertension:Oral:Adult: 200 mcg once daily, increase if necessary after 3 wk to 400 mcg daily as single or in 2 divided doses. If necessary, after a further 3 wk, increase to 600 mcg daily in 2 divided doses. Max: 600 mcg daily.
Schedule of Moxonidine
N/A
Storage Requirements for Moxonidine
Do not store above 25?C.
Effects of Missed Dosage of Moxonidine
If you miss a dose ignore it and take the next dose at the normal time. Do not take two doses together to make up for the one you have missed.
Effects of Overdose of Moxonidine
1.Taking too much moxonidine may cause the following: sedation (confusion and sleepiness), low or high blood pressure, dizziness, fainting, sickness, dry mouth, slowing of heart rate, shortness of breath, narrowing of the pupil of the eye (miosis) and coma.
2.People who have taken too much moxonidine should call a doctor or go to the nearest hospital casualty department immediately.

Amlodipine

About Amlodipine
Calcium Channel Blocker, Anti hypertensive,anti angina.
Mechanism of Action of Amlodipine
Amlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.
Pharmacokinets of Amlodipine
Absorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.
Onset of Action for Amlodipine
Slow
Duration of Action for Amlodipine
24 hours
Half Life of Amlodipine
N/A
Side Effects of Amlodipine
1.Palpitation
2.Flushing
3.Nausea
4.Vomiting
5.Abdominal pain
6.Edema
7.Headache
8.Dizziness
9.Paresthesia
10.Light headedness
11.Fatigue
12.Aggravates myocardial ischaemia
13.Rashes
Contra-indications of Amlodipine
1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine
1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.
Children Related Information
Contraindicated
Indications for Amlodipine
1.Hypertension
2.Prinzmetal`s angina
3.Stable angina
Interactions for Amlodipine
ACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.
Typical Dosage for Amlodipine
5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
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Schedule of Amlodipine
H
Storage Requirements for Amlodipine
Store at room temperature below 30 degree C. Protect from moisture and light.

Effects of Missed Dosage of Amlodipine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Amlodipine
Monitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.

Home Delivery for Moxonidine + Amlodipine in Your City

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Moxonidine + Amlodipine is a generic medicine name and there are several brands available for it. Some of the brands for moxonidine + amlodipine might be better known than moxonidine + amlodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have moxonidine + amlodipine in stock, you can ask for one of the branded alternatives for moxonidine + amlodipine.