Moxonidine Pharmacology

Moxonidine

About Moxonidine
Centrally-acting antihypertensive.
Mechanism of Action of Moxonidine
Moxonidine is a centrally-acting antihypertensive. It acts in the brainstem through stimulation of central imidazoline receptors to reduce sympathetic tone. Moxonidine also has a low affinity for ?2-adrenoceptors.
Pharmacokinets of Moxonidine
Absorption: Absorbed rapidly from the GI tract
Distribution: Plasma protein binding around 7%; present in breast milk
Excretion: Excreted in the urine (78% as unchanged drug)
Onset of Action for Moxonidine
N/A
Duration of Action for Moxonidine
N/A
Half Life of Moxonidine
N/A
Side Effects of Moxonidine
1.Dry mouth
2.Headache
3.Fatigue
4.Dizziness
5.Nausea
6.Sleep disturbances
7.Asthenia
8.Vasodilatation
9.Skin reactions
10.Constipation
11.Depression
12.Anxiety
13.Anorexia
14.Parotid pain
15.Vivid dreams
16.Impotence and loss of libido
17.Urinary retention or incontinence
18.Slight orthostastic hypotension
19.Fluid retention
Contra-indications of Moxonidine
1.Conduction disorders
2.Bradycardia
3.Severe arrhythmias
4.Severe heart failure
5.Severe ischaemic heart disease
6.History of angioedema
7.Severe liver or renal impairment
8.Raynaud's syndrome
9.Intermittent claudication
10.Epilepsy
11.Depression
12.Parkinson's disease
13.Glaucoma
Special Precautions while taking Moxonidine
1.Renal impairment
2.Avoid abrupt withdrawal (if concomitant treatment with ?-blocker has to be stopped, discontinue ?-blocker first, then moxonidine after few days)
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
Contra indicatedaged under 18 years.
Indications for Moxonidine
Hypertension
Interactions for Moxonidine
1.Additive effects with other antihypertensives
2.May increase sedative effects of benzodiazepines
3.Effects may be antagonised by TCAS
Typical Dosage for Moxonidine
Hypertension:Oral:Adult: 200 mcg once daily, increase if necessary after 3 wk to 400 mcg daily as single or in 2 divided doses. If necessary, after a further 3 wk, increase to 600 mcg daily in 2 divided doses. Max: 600 mcg daily.
Schedule of Moxonidine
N/A
Storage Requirements for Moxonidine
Do not store above 25?C.
Effects of Missed Dosage of Moxonidine
If you miss a dose ignore it and take the next dose at the normal time. Do not take two doses together to make up for the one you have missed.
Effects of Overdose of Moxonidine
1.Taking too much moxonidine may cause the following: sedation (confusion and sleepiness), low or high blood pressure, dizziness, fainting, sickness, dry mouth, slowing of heart rate, shortness of breath, narrowing of the pupil of the eye (miosis) and coma.
2.People who have taken too much moxonidine should call a doctor or go to the nearest hospital casualty department immediately.

Home Delivery for Moxonidine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including moxonidine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for moxonidine and other medicines and health products. Home delivery services for moxonidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take moxonidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for moxonidine before they complete the sale. You can get this information while placing the order for moxonidine with the pharmacy.

Moxonidine is a generic medicine name and there are several brands available for it. Some of the brands for moxonidine might be better known than moxonidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have moxonidine in stock, you can ask for one of the branded alternatives for moxonidine.