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- Pharmacology For Mosapride + Pantoprazole
Mosapride + Pantoprazole Pharmacology
Mosapride + Pantoprazole
About Mosapride + PantoprazoleN/AMechanism of Action of Mosapride + PantoprazoleN/APharmacokinets of Mosapride + PantoprazoleN/AOnset of Action for Mosapride + PantoprazoleN/ADuration of Action for Mosapride + PantoprazoleN/AHalf Life of Mosapride + PantoprazoleN/ASide Effects of Mosapride + PantoprazoleN/AContra-indications of Mosapride + PantoprazoleN/ASpecial Precautions while taking Mosapride + PantoprazoleN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationContraindicatedChildren Related InformationN/AIndications for Mosapride + Pantoprazole1.Acid reflux diseases
2.Irritable bowel syndrome
3.Functional dyspepsia
Interactions for Mosapride + PantoprazoleN/ATypical Dosage for Mosapride + PantoprazoleN/ASchedule of Mosapride + PantoprazoleN/AStorage Requirements for Mosapride + PantoprazoleN/AEffects of Missed Dosage of Mosapride + PantoprazoleN/AEffects of Overdose of Mosapride + PantoprazoleN/AMosapride
About MosaprideA selective 5HT4 agonist, A gastroprokinetic agent.Mechanism of Action of MosaprideMosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.Pharmacokinets of MosaprideAbsorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.
Onset of Action for MosaprideN/ADuration of Action for MosaprideN/AHalf Life of Mosapride2 - 3 hoursSide Effects of Mosapride1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Dry mouth
5.Nausea
Contra-indications of Mosapride1.Hypersensitivity to MosaprideSpecial Precautions while taking Mosapride1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES: contraindicated
Indications for Mosapride1.Gastroesophageal reflux diseases
2.Functional dyspepsia
3.Diabetic gastropathy
4.Disorders associated with decreased gastric motility
5.Nausea
Interactions for MosaprideMosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride. Typical Dosage for MosaprideAdult:
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Children:not recommended
Schedule of MosaprideN/AStorage Requirements for MosaprideStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of MosaprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of MosaprideGive supportive measures and symptomatic treatment.
Pantoprazole
About PantoprazoleA proton pump inhibitor, Benzimidazole derivative, Anti ulcer.Mechanism of Action of PantoprazolePantoprazole is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Pantoprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump
(H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Pantoprazole irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Pantoprazole is more acid stable and its activity is lowered in higher pH. It is the only proton pump inhibitor which is available as parenteral form.
Pharmacokinets of PantoprazoleAbsorption: Pantoprazole is well absorbed after oral administration. Its bioavailability is about 77% since it`s undergoes first pass metabolism.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Pantoprazole is extensively metabolised in the liver.
Excretion: It is excreted mainly in the urine and small amount in faeces.
Onset of Action for Pantoprazole2-4 hoursDuration of Action for Pantoprazole1 dayHalf Life of Pantoprazole60 minutesSide Effects of Pantoprazole1. Diarrhoea
2. Nausea
3. Vomiting
4. Headache
5. Flatulence
6. Abdominal pain
7. Pruritis
8. Dizziness
9. Rash
Contra-indications of Pantoprazole1. Hypersensitivity to PantoprazoleSpecial Precautions while taking Pantoprazole1. Hepatic impairment
2. Monitor liver function
3. Avoid prolonged use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationUse with caution
Below 12 years : Contraindicated
Indications for Pantoprazole1. Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Gastroesophageal reflux disease
Interactions for PantoprazolePhenazone (antipyrine), diazepam, digoxin, theophylline, carbamazepine, diclofenac, phenprocoumon, phenytoin, warfarin, nifedipine, caffeine, metoprolol or ethanol : No clinically relevant interaction at therapeutic doses.
Oral contraceptives : Does not appear to compromise hormonal contraceptive efficacy as no interaction with a low dose combined oral contraceptive has been seen.
Typical Dosage for PantoprazoleOral :
Adult: 20-40mg / day before breakfast.
Duodenal ulcer: 40mg / day to be taken before breakfast for 2 - 4 weeks.
Benign Gastric ulcer: 40mg / day to be taken before breakfast for 1 - 2months.
Zollinger- Ellison syndrome: 80 mg / day in 2 divided doses increase the dose to 240 mg/ day if needed.
Gastroesophageal reflux disease: 20 - 40 mg / day to be taken before breakfast for 1 month and continue the treatment for 1 more month if needed.
Parenteral: 40 mg once daily as IV injection over 15 minutes.
Children below 12 years : Not recommended
Schedule of PantoprazoleHStorage Requirements for PantoprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of PantoprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PantoprazoleGive supportive measures and symptomatic treatment.Home Delivery for Mosapride + Pantoprazole in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mosapride + pantoprazole and other medicines and health products. Home delivery services for mosapride + pantoprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Mosapride + Pantoprazole is a generic medicine name and there are several brands available for it. Some of the brands for mosapride + pantoprazole might be better known than mosapride + pantoprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mosapride + pantoprazole in stock, you can ask for one of the branded alternatives for mosapride + pantoprazole.