Clotrimazole + Beclomethasone + Neomycin + Chlorocresol Pharmacology

Clotrimazole + Beclomethasone + Neomycin + Chlorocresol

About Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Mechanism of Action of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Pharmacokinets of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Onset of Action for Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Duration of Action for Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Half Life of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Side Effects of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
1.Skin thinning
2.Skin atrophy
3.Telangiectasia
Contra-indications of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
N/A
Special Precautions while taking Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
Mixed(fungal and/ or bacterial) infection associated with inflammation.
Interactions for Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
N/A
Typical Dosage for Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
To be applied as a thin film over the effected area 2-3 times daily.
Schedule of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Storage Requirements for Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Effects of Missed Dosage of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Effects of Overdose of Clotrimazole + Beclomethasone + Neomycin + Chlorocresol
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Clotrimazole

About Clotrimazole
A broad-spectrum antifungal antibiotic, imidazole derivative, Oral Nonabsorbed Antifungal Agent.
Mechanism of Action of Clotrimazole
Clotrimazole is fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis which is an essential constituent of cell membrane. Inhibition of ergosterol synthesis will alter the membrane permeability of the susceptible fungus and kill or inhibit them.
Pharmacokinets of Clotrimazole
Absorption: Absorption is minimal after topical administration.
Onset of Action for Clotrimazole
N/A
Duration of Action for Clotrimazole
3 hours
Half Life of Clotrimazole
N/A
Side Effects of Clotrimazole
1.Stinging
2.Erythema
3.Burning
4.Pruritis
5.Vesication
6.Desquamation
7.Urticaria
8.Burning
9.Peeling
10.Irritation
Contra-indications of Clotrimazole
Hypersensitivity to Clotrimazole
Special Precautions while taking Clotrimazole
1.Avoid contact with eyes, nose and mouth.
2.Do not wear occlusive dress over the medicament.
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
NEONATES: contraindicated
Indications for Clotrimazole
1.Tinea pedis
2.Tinea cruris
3.Tinea versicolor
4.Tinea corporis
5.Cutaneous candidiasis
6.Vulvovaginal candidiasis
Interactions for Clotrimazole
Polyene Antibiotics : Antagonises effects of polyene antibiotics.
Typical Dosage for Clotrimazole
Topical: Clotrimazole cream, lotion and solution 1 % is used.
Clean and dry the affected area and apply the medicament with gentle massage 2 -3 times daily for 2 - 4 weeks.
Vaginal candidiasis: Insert 1 applicator full (vaginal cream 1%) intravaginally at night for 1 -2 weeks.
Vaginal tablets 100. 200 and 500mg tablet is available.
Vulvovaginal candidiasis: Insert 100mg tablet intravaginally at bed time for 7 consecutive days or 200 mg tablet for 3 consecutive days or 500 mg tablet for 1 day at night.
Oral lozenge 10 mg is available
Oropharyngeal candidiasis: 1 lozenge orally 5 times daily for 2 weeks
Prophylaxis of Oropharyngeal candidiasis: 1 lozenge is used 3 times daily
Gel: Insert with an applicator intravaginally at night for 1 - 2 weeks.
Powder (1% w/ w): dusted over the body parts as required
Schedule of Clotrimazole
H
Storage Requirements for Clotrimazole
Store at room temperature (15 - 25 degree C). Protect from heat and moisture. Keep out of the reach of children
Effects of Missed Dosage of Clotrimazole
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clotrimazole
Give supportive measures and symptomatic treatment.

About
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Special Precautions while taking
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Pregnancy Related Information
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Typical Dosage for
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Neomycin

About Neomycin
An aminoglycoside, Antibiotic, Ammonium Detoxicant.
Mechanism of Action of Neomycin
This aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Pharmacokinets of Neomycin
Absorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin
1 to 4 hr after oral administration
Duration of Action for Neomycin
8hrs after oral administration
Half Life of Neomycin
Its plasma half life is 2 to 3 hrs
Side Effects of Neomycin
1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin
1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin
1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Neomycin
1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for Neomycin
N/A
Typical Dosage for Neomycin
Ophthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of Neomycin
C
Storage Requirements for Neomycin
Eye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.
Effects of Missed Dosage of Neomycin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Neomycin
Give symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drug

Chlorocresol

About Chlorocresol
A potent chlorinated phenolic compound, Bactericide ,Antiseptic , Disinfectant, Preservative.

Mechanism of Action of Chlorocresol
Chlorocresol is a potent chlorinated phenolic disinfectant, antiseptic and bactericide. It has bactericidal activity against Gram-positive and Gram-negative bacteria and is effective against fungi but has little activity against bacterial spores except at high temperatures. It is more active in acid than in alkaline solution.
Chlorocresol is used in preparations for disinfection of the skin and wounds. It is also used as a preservative in cosmetics and in creams and other preparations for external use that contain water.
Chlorocresol is used as a preservative in aqueous injections issued in multidose containers. It is used as a preservative in pharmaceutical creams and lotions, especially steroid creams.
Chlorocresol is used in preparations for disinfection of the skin and wounds. It is also used as a preservative in cosmetics and in creams and other preparations for external use that contain water.
Pharmacokinets of Chlorocresol
Absorption: It is applied topically
Onset of Action for Chlorocresol
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Duration of Action for Chlorocresol
N/A
Half Life of Chlorocresol
N/A
Side Effects of Chlorocresol
Sensitisation reactions
Contra-indications of Chlorocresol
Hypersensitivity to the drug
Special Precautions while taking Chlorocresol
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Chlorocresol
Antiseptic
Interactions for Chlorocresol
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Typical Dosage for Chlorocresol
As directed by the Physician
Schedule of Chlorocresol
N/A
Storage Requirements for Chlorocresol
Store at room temperature away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Chlorocresol
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Chlorocresol
Give supportive measures and symptomatic treatment.

Home Delivery for Clotrimazole + Beclomethasone + Neomycin + Chlorocresol in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clotrimazole + beclomethasone + neomycin + chlorocresol and other medicines and health products. Home delivery services for clotrimazole + beclomethasone + neomycin + chlorocresol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clotrimazole + beclomethasone + neomycin + chlorocresol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clotrimazole + beclomethasone + neomycin + chlorocresol before they complete the sale. You can get this information while placing the order for clotrimazole + beclomethasone + neomycin + chlorocresol with the pharmacy.

Clotrimazole + Beclomethasone + Neomycin + Chlorocresol is a generic medicine name and there are several brands available for it. Some of the brands for clotrimazole + beclomethasone + neomycin + chlorocresol might be better known than clotrimazole + beclomethasone + neomycin + chlorocresol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clotrimazole + beclomethasone + neomycin + chlorocresol in stock, you can ask for one of the branded alternatives for clotrimazole + beclomethasone + neomycin + chlorocresol.