Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide Pharmacology

Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide

About Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
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Mechanism of Action of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
Kojic Acid: A Potent Tyrosinase Inhibitor
Arbutin: A Non irritating Glycosylated Hydroquinone
Octinoxate : An Effective Sunscreen agent
Vitamin E: Anti oxidant with Skin lightening effect
Pine Bark Extract : Photo Protective, Anti Aging, Improves microcirculation
Allantoin : Mild Keratolytic and Moisturizer
Niacinamide : Inhibits Melanosome transfer from Melanocytes
Combination Reduces Melanin Synthesis and Promotes Skin Lightening
Pharmacokinets of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
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Onset of Action for Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
N/A
Duration of Action for Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
N/A
Half Life of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
N/A
Side Effects of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
N/A
Contra-indications of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
N/A
Special Precautions while taking Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
1.Chloasma / Melasma
2.Photo Melanosis
3.Post Inflammatory Hyperpigmentation
4.Peri Orbital & Peri Oral Melanosis
5.Age spots & Premature Aging Skin

Interactions for Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
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Typical Dosage for Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
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Schedule of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
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Storage Requirements for Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
N/A
Effects of Missed Dosage of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
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Effects of Overdose of Kojic Acid + Arbutin + Octinoxate + Vitamin E + Pine Bark Extracts + Allantoin + Niacinamide
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Kojic acid

About Kojic acid
Melanin inhibitor, A demelanizing agent.
Mechanism of Action of Kojic acid
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Pharmacokinets of Kojic acid
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Onset of Action for Kojic acid
N/A
Duration of Action for Kojic acid
N/A
Half Life of Kojic acid
N/A
Side Effects of Kojic acid
N/A
Contra-indications of Kojic acid
N/A
Special Precautions while taking Kojic acid
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Kojic acid
N/A
Interactions for Kojic acid
N/A
Typical Dosage for Kojic acid
N/A
Schedule of Kojic acid
N/A
Storage Requirements for Kojic acid
N/A
Effects of Missed Dosage of Kojic acid
N/A
Effects of Overdose of Kojic acid
N/A

Arbutin

About Arbutin
A glycosylated hydroquinone extracted from bearberry plant.
Mechanism of Action of Arbutin
It inhibits tyrosinase and thus prevents the formation of melanin. Arbutin is therefore used as a skin-lightening agent.
Pharmacokinets of Arbutin
N/A
Onset of Action for Arbutin
N/A
Duration of Action for Arbutin
N/A
Half Life of Arbutin
N/A
Side Effects of Arbutin
N/A
Contra-indications of Arbutin
N/A
Special Precautions while taking Arbutin
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Arbutin
1.Postinflammatory hyperpigmentation caused by acne, trauma, allergic reactions, infections, injuries, phototoxic reactions, reactions to medications, reactions to cosmetics, and inflammatory diseases.
2.Melasma (Dark skin discoloration).
Interactions for Arbutin
N/A
Typical Dosage for Arbutin
N/A
Schedule of Arbutin
N/A
Storage Requirements for Arbutin
N/A
Effects of Missed Dosage of Arbutin
N/A
Effects of Overdose of Arbutin
N/A

Octinoxate

About Octinoxate
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Mechanism of Action of Octinoxate
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Pharmacokinets of Octinoxate
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Onset of Action for Octinoxate
N/A
Duration of Action for Octinoxate
N/A
Half Life of Octinoxate
N/A
Side Effects of Octinoxate
N/A
Contra-indications of Octinoxate
N/A
Special Precautions while taking Octinoxate
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Pregnancy Related Information
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Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
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Indications for Octinoxate
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Interactions for Octinoxate
N/A
Typical Dosage for Octinoxate
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Schedule of Octinoxate
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Storage Requirements for Octinoxate
N/A
Effects of Missed Dosage of Octinoxate
N/A
Effects of Overdose of Octinoxate
N/A

Vitamin E

About Vitamin E
N/A
Mechanism of Action of Vitamin E
Vitamin E acts as an antioxidant and protecting unsaturated lipids in the cell membrane, coenzyme Q, vitamin A, vitamin C etc. from free radical oxidation damage and generation of toxic peroxidation products. It also decreases platelet aggregation.
Pharmacokinets of Vitamin E
Absorption: Absorbed through lymph with the help of bile. Only 20 to 60% of vitamin from dietary sources is absorbed. As dose increases the fraction absorbed decreases.
Distribution: Widely distributed in a protein bound form and stored in adipose tissue.
Metabolism: Metabolized in liver by glucuronide conjugation.
Excretion: Excreted mainly through bile and also excreted through urine.
Onset of Action for Vitamin E
N/A
Duration of Action for Vitamin E
N/A
Half Life of Vitamin E
N/A
Side Effects of Vitamin E
1. Fatigue
2. Weakness
3. Headache
4. Nausea
5. Diarrhoea
6. Blurred vision
7. Flatulence


Contra-indications of Vitamin E
1. Hypersensitivity to the drug
2. Should not administer intravenously
Special Precautions while taking Vitamin E
1. Hepatic impairment
2. Gall bladder disease
3. Along with estrogens
Pregnancy Related Information
May be used
Old Age Related Information
N/A
Breast Feeding Related Information
May be used
Children Related Information
N/A
Indications for Vitamin E
1. Vitamin E deficiency
2. Intermittent claudication
3. Nocturnal muscle cramps
4. Coronary artery disease
5. Fibrocystic breast disease
6. Cystic fibrosis
7. In premature infants exposed to high concentration of oxygen
8. As antioxidant


Interactions for Vitamin E
Oral anticoagulants : Hypoprothrombinemic effect may be increased with possibility of bleeding.

Typical Dosage for Vitamin E
Oral:
Vitamin E deficiency:
Adults: 40 to 50mg/day or 60 to 75i.u. daily based on the severity of deficiency.
Children: 1 unit/kg/day.
Premature neonates: 5units daily.
Full term neonates: 5 units per liter of formula.
Intermittent claudication: 400mg/day for 12 to 18 weeks.
Nocturnal muscle cramps: 400mg/day for 8 to 12 weeks.
Coronary artery disease: 100 to 200mg/day for at least 2 years.
Fibrocystic breast disease: 600mg/day for at least 2years.
Cystic fibrosis: 100 to 200mg/day.
Children above 1 year: 100mg/day.
Children below 1year: 50mg/day.



Schedule of Vitamin E
C1
Storage Requirements for Vitamin E
Store in a well closed container in a cool dry place. Protect from light.
Effects of Missed Dosage of Vitamin E
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Vitamin E
Provide supportive measures and symptomatic treatment.

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Allantoin

About Allantoin
Skin-softening (keratolytic), cell-proliferating healing agent, abrasive and astringent agent.
Mechanism of Action of Allantoin
Allantoin works by slowing bacterial growth and loosing and softening scales and crust.The keratolytic effect and abrasive and astringent properties of Allantoin are used in skin softening cosmetic preparations.
Allantoin is a moisturizing, soothing, healing, anti-irritating, keratolytic and non-toxic agent. Allantoin is a cell-proliferating healing agent which stimulates healthy tissue formation. It removes necrotic and scaling tissue
Pharmacokinets of Allantoin
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Onset of Action for Allantoin
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Duration of Action for Allantoin
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Half Life of Allantoin
N/A
Side Effects of Allantoin
1.Rash
2.Itchy skin
Contra-indications of Allantoin
1.Hypersensitivity to Allantoin
2.Persons allergy to sunlight
Special Precautions while taking Allantoin
1.For external use only

Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
May be used
Children Related Information
May be used
Indications for Allantoin
1.Heal wounds
2.Relieving itching, skin irritations, scaling, dryness, and flaking of the skin due to dandruff, eczema, psoriasis, and seborrhea
3.Stimulate growth of healthy tissue
Interactions for Allantoin
N/A
Typical Dosage for Allantoin
Apply the medicament to the affected area 2 - 3 times daily.
Schedule of Allantoin
N/A
Storage Requirements for Allantoin
Store at room temperature. Keep out of the reach of children.
Effects of Missed Dosage of Allantoin
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule.
Effects of Overdose of Allantoin
Give supporive measures and symptomatic treatment.

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