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- Pharmacology For Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin Pharmacology
Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin
About Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AMechanism of Action of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin1.Aceclofenac relieves pain & inflammation.
2.Methyl Salicylate provides counter-irritant action.
3.Menthol enhances Aceclofenac absorption and provides cooling action.
4.Linseed oil helps in reducing inflammation.
5.Capsaicin provides counter-irritant action.
Pharmacokinets of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AOnset of Action for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/ADuration of Action for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AHalf Life of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/ASide Effects of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AContra-indications of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/ASpecial Precautions while taking Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin1.Back pain
2.Knee pain
3.Sprain & strains
4.Soft tissue disorders
5.Osteoarthritis Knee
6.Spondylosis
7.Cervical spondylosis
8.Injury
9.Arthritis
10.Shoulder lesions
11.Frozen Shoulder
12.Prolapsed intervertebral disc
13.Thumb, knee, shoulder stiffness
14.Rheumatoid arthritis
15.Tennis elbow
Interactions for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/ATypical Dosage for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/ASchedule of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AStorage Requirements for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AEffects of Missed Dosage of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AEffects of Overdose of Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + CapsaicinN/AAceclofenac
About AceclofenacNSAID, Analgesic, Antiinflammatory, Anti arthritic.Mechanism of Action of AceclofenacThis drug has several mechanism of action.
1. It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action).
2. It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines.
3. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production.
4. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen.
5. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs.
6. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils.
7. Aceclofenac is also an NSAID with greater COX-2 specificity
Pharmacokinets of AceclofenacAbsorption- It is rapidly and completely absorbed after oral administration
Distribution- Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma.
Metabolism- Metabolized into metabolites in the liver. Main metabolite is 4-hydroxyaceclofenac
Excretion- It is excreted through urine mainly as conjugated hydroxymetabolites
Onset of Action for AceclofenacN/ADuration of Action for AceclofenacN/AHalf Life of AceclofenacThe mean plasma elimination half-life is 4 - 4.3 hoursSide Effects of Aceclofenac1. Dyspepsia
2. Abdominal pain
3. Dizziness
4. Vertigo
5. Pruritis
6. Rash
7. Dermatitis
8. Nausea
9. Diarrhoea
10. Flatulence
11. Gastritis
12. Constipation
13. Vomiting
14. Ulcerative stomatitis
15. Elevation of circulating levels of hepatic enzymes.
Contra-indications of Aceclofenac1. Hypersensitivity to the drug
2. Bleeding from the stomach or intestines
3. Moderate to severely decreased kidney function
4. Hypersensitivity to other NSAIDs
5. Active peptic ulcer
Special Precautions while taking Aceclofenac1. Hepatic porphyria
2. Bleeding tendencies
3. Blood disorders
4. Crohn`s disease
5. Decreased heart function
6. History of peptic ulcers
7. Inflammation of the bowel and back passage
8. Mildly decreased kidney function
9. Recent major surgery
10. Stomach disorders
11. Decreased liver function
12. Intestinal disorders
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicated.Children Related InformationUse with cautionIndications for Aceclofenac1. Ankylosing spondylitis
2. Osteoarthritis
3. Symptomatic treatment of pain and inflammation in Post-Traumatic pain
4. Cervical pain
5. Low back pain
6. Acute gout
Interactions for AceclofenacLithium, digoxin and methotrexate: Aceclofenac may increase plasma concentrations of lithium, digoxin and methotrexate.
Anticoagulants: Activity of anticoagulants may be increased.
Diuretics : Aceclofenac inhibits the activity of diuretics. When concomitantly administrated with potassium sparing diuretics, serum potassium should be monitored.
Cyclosporin: Aceclofenac may enhance cyclosporin nephrotoxicity.
Quinolones : Aceclofenac may precipitate convulsions when coadministered with quinolone antibiotics.
Typical Dosage for AceclofenacOral-
Adult (general dose)-
100mg twice daily
Schedule of AceclofenacHStorage Requirements for AceclofenacStore below 25?CEffects of Missed Dosage of AceclofenacTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AceclofenacGive symptomatic and supportive treatment. Induce gastric lavage and administer charcoal in repeated doses. Treated with antacid if necessary.Methyl salicylate
About Methyl salicylateSalicylates, Rubefacient, counterirritant.Mechanism of Action of Methyl salicylateMethyl salicylate is a rubefacient. It produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. It is also called as counterirritant because they produce their action by counter irritation. Irritation of the sensory nerve endings alters pain in the underlying muscle or joints that are served by the same nerves.Pharmacokinets of Methyl salicylateN/AOnset of Action for Methyl salicylateN/ADuration of Action for Methyl salicylateN/AHalf Life of Methyl salicylateN/ASide Effects of Methyl salicylateN/AContra-indications of Methyl salicylateN/ASpecial Precautions while taking Methyl salicylateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Methyl salicylateN/AInteractions for Methyl salicylateN/ATypical Dosage for Methyl salicylateN/ASchedule of Methyl salicylateN/AStorage Requirements for Methyl salicylateN/AEffects of Missed Dosage of Methyl salicylateN/AEffects of Overdose of Methyl salicylateN/AMenthol
About MentholTerpenes and terpenoid, Antipruritic, decongestant, topical analgesic.Mechanism of Action of MentholMenthol acts as a local anesthetic on the respiratory passageways and causing cough suppression. When Menthol is rubbed on the skin, it acts as a rubefacient and causes localized vasodilatation; which gives feelings of comfort and warmth. When applied gently on the skin, it acts as an anti-pruritic agent and creates a feeling of coolness, and mild local anaesthetic effect relieves itching. It has good soothing effect and acts as a demulcent. It also acts as a carminative.Pharmacokinets of MentholN/AOnset of Action for MentholN/ADuration of Action for MentholN/AHalf Life of MentholN/ASide Effects of Menthol1.Irritation
2.Anxiety
3.Excitement
4.Delirium
5.Colic
6.Nausea
7.Vomiting
8.Diarrhoea
9.Convulsions
10.Apnoea
11.Asystole
12.Contact dermatitis
13.Allergic reactions
Contra-indications of Menthol1. Hypersensitivity to the drug
2.Should not applies to broken, injured, or burned skin
Special Precautions while taking Menthol1.Should not apply Menthol directly in to or near the nostrils of small children or asthma patients
2.Prolonged use
3.Seizures
4.Should not take steam inhalation orally
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution
Children Related InformationUse with caution
below 2 years: ContraindicatedIndications for Menthol1. Rubefacient.
2.Ingredient in cough preparations
3.Antipruritic
4. Ingredient in ointment or liniment to treat sprains; joint and muscle pain
5.Sore throat
6.Cold sores
7.Hay fever
8.As an inhalant to relieve nasal, bronchial, or upper respiratory congestion
9.Sinusitis
10.Bronchial cough
11.Pharyngeal inflammation
Interactions for MentholN/ATypical Dosage for MentholDosage individualized based on requirements of the patient.
Lozenges: Dissolve lozenge (5%-10% menthol) slowly in the mouth hourly as needed by the patients.
Topical: Rubbed on the throat and chest in a layer loosely covered with a warm dry cloth; up to thrice daily.
In vaporizer: Menthol (3.2%) in a hot steam vaporizer can be used by adding 1 tbsp of solution for each quart of cold water, or 1tsp of solution for each pint, up to thrice daily
Schedule of MentholN/AStorage Requirements for MentholStore at a cool dry place in a well closed container. Protect from light and heat. Keep out of reach of children.Effects of Missed Dosage of MentholTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MentholProvide symptomatic treatment and supportive measures.Linseed Oil
About Linseed OilIt contains powerful, rare natural antioxidants (lignans), omega-3 fatty acids, vitamins and minerals. It is a popular oil in cosmetic manufacturing and to a lesser degree (but no less suitable), massage therapists and aroma therapists. Linseed oil is also well absorbed by the skin.Mechanism of Action of Linseed OilN/APharmacokinets of Linseed OilN/AOnset of Action for Linseed OilN/ADuration of Action for Linseed OilN/AHalf Life of Linseed OilN/ASide Effects of Linseed OilN/AContra-indications of Linseed OilN/ASpecial Precautions while taking Linseed OilTaking blood thinners may not be safe to use along with flaxseed oil as treatment for a medical condition. Flaxseed will make your blood thinning medication more effective, which could be dangerous.
Pregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Linseed Oil1.Lower Cholesterol:Flaxseed oil and other sources of omega-3 fatty acids may increase your level of HDL--what is commonly called "good" cholesterol--and can help lower LDL ("bad" cholesterol) levels.
2.Healthy Heart:One of the elements in flaxseed oil, called alpha-linolenic acid (ALA), can lower your risk of heart disease through a number of factors. ALA keeps your blood vessels healthy, keeps platelets from sticking together and may even prevent minor arrhythmias.
3.Reduce Inflammation:The omega-3 found in flaxseed oil is a naturally-occurring anti-inflammatory agent. People who have arthritis, lupus, psoriasis and inflammatory bowel disorders may find a reduction in inflammation by adding flaxseed oil to their diets.
Interactions for Linseed OilN/ATypical Dosage for Linseed OilAdults can safely take up to 2 tbsp. of flaxseed oil or two soft-gels daily for medical use. Check with your doctor before giving your child flaxseed oil.Schedule of Linseed OilN/AStorage Requirements for Linseed OilN/AEffects of Missed Dosage of Linseed OilN/AEffects of Overdose of Linseed OilN/ACapsaicin
About CapsaicinA lipophilic capsaicinoid(methyl vanillyl nonenamide),substance P release inducer, A topical analgesic ,antineuralgic and antipruritic, rubefacient.Mechanism of Action of CapsaicinCapsaicin is a rubefacient. It produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. It is also called as counterirritant because they produce their action by counter irritation. Irritation of the sensory nerve endings alters pain in the underlying muscle or joints that are served by the same nerves.
Capsaicin depletes the neurochemical substance P which transmits pain and desensitizes person to pain. Capsaicin produces a temporary reduction in pain.Pharmacokinets of CapsaicinN/AOnset of Action for CapsaicinN/ADuration of Action for CapsaicinN/AHalf Life of CapsaicinN/ASide Effects of Capsaicin1.Warm
2.Stinging
3.Burning
4.Skin redness
Contra-indications of CapsaicinHypersensitivity to CapsaicinSpecial Precautions while taking Capsaicin1.Wear gloves when applying cream.
2.Do not apply after a hot bath or shower or use it with a heating pad.
3.Avoid contact with eyes, mucus membranes or broken skin
4.Broken or irritated skin
5.Prolonged use
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
Below 2 years:ContraindicatedIndications for Capsaicin1.Back pain
2.Bursitis
3.Fibromyalgia
4.Joint pain
5.Muscle pain
6.Nerve Pain
7.Osteoarthritis
8.Pain due to diabetic neuropathy
9.Post-herpetic neuralgia
10.Post-surgical neuropathic pain
Interactions for CapsaicinN/ATypical Dosage for CapsaicinTopical
For neuralgia or itching of the skin:
Adults: Apply 0.025% cream 3 or 4 times a day and rub well and if sufficient response is not obtained apply 0.075% cream.
Children: Same as adult dose
Below 2 years: Contraindicated
Schedule of CapsaicinN/AStorage Requirements for CapsaicinStore the medicine in a closed container at room temperature. Keep away from heat, moisture and direct light. Keep out of the reach of children.Effects of Missed Dosage of CapsaicinApply the missed dose as soon as remember and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the doses.Effects of Overdose of CapsaicinGive supportive measures and symptomatic treatment.Home Delivery for Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin in Your City
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Aceclofenac + Methyl Salicylate + Menthol + Linseed Oil + Capsaicin is a generic medicine name and there are several brands available for it. Some of the brands for aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin might be better known than aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin in stock, you can ask for one of the branded alternatives for aceclofenac + methyl salicylate + menthol + linseed oil + capsaicin.