- Medicine India
- Generic Medicines
- M
- Pharmacology For Montelukast + Fexofenadine
Montelukast + Fexofenadine Pharmacology
Montelukast + Fexofenadine
About Montelukast + FexofenadineN/AMechanism of Action of Montelukast + FexofenadineN/APharmacokinets of Montelukast + FexofenadineN/AOnset of Action for Montelukast + FexofenadineN/ADuration of Action for Montelukast + FexofenadineN/AHalf Life of Montelukast + FexofenadineN/ASide Effects of Montelukast + FexofenadineN/AContra-indications of Montelukast + FexofenadineN/ASpecial Precautions while taking Montelukast + FexofenadineN/APregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationContraindicatedIndications for Montelukast + Fexofenadine1.Persistent allergic rhinitis
2.Asthma
3.Skin allergies
Interactions for Montelukast + FexofenadineN/ATypical Dosage for Montelukast + FexofenadineN/ASchedule of Montelukast + FexofenadineN/AStorage Requirements for Montelukast + FexofenadineN/AEffects of Missed Dosage of Montelukast + FexofenadineN/AEffects of Overdose of Montelukast + FexofenadineN/AMontelukast
About MontelukastLeukotriene(CysLT1) Receptor Antagonist, Antiinflammatory,antiasthma.Mechanism of Action of MontelukastMontelukast is competitively and selectively antagonizes CysLT1 receptor (leukotrienes receptor) mediated Bronchoconstriction.Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity.
Pharmacokinets of MontelukastAbsorption: Montelukast is rapidly absorbed after oral administration and its bioavailability is about 60 - 70%.
Distribution: It is minimally distributed to the tissues in protein bound form (99%)
Metabolism: It is extensively metabolised in the liver.
Excretion: Montelukast is excreted in the faeces.
Onset of Action for MontelukastN/ADuration of Action for MontelukastN/AHalf Life of Montelukast2.75 - 5.5 hoursSide Effects of Montelukast1.Headache
2.Dizziness
3.Nasal congestion
4.Sore throat
5.Abdominal pain
6.Fatigue
7.Asthenia
8.Cough
9.Influenza
10.Rash
11.Fever
12.Trauma
13.Trauma
14.Dyspepsia
Contra-indications of Montelukast1.Hypersensitivity to Montelukast
2.Acute asthmatic attacksSpecial Precautions while taking MontelukastN/APregnancy Related InformationUse with caution.Old Age Related InformationMay be used.Breast Feeding Related InformationUse with caution.Children Related InformationMay be used
CHILDREN below 6 years : contraindicated
NEONATES: contraindicated
Indications for MontelukastAsthma.Interactions for MontelukastBarbiturates & Primidone: Plasma concentration of montelukast is reduced by phenobarbital.
Typical Dosage for MontelukastAdult: 10 mg / day at bed time
Children (6 - 14 years): 5mg/day at bed time
Schedule of MontelukastN/AStorage Requirements for MontelukastStore at room temperature. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of MontelukastTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MontelukastGive supportive measures and symptomatic treatmentFexofenadine
About FexofenadineSecond Generation H1 Antagonist, Antihistamine.Mechanism of Action of FexofenadineFexofenadine blocks one type of peripheral receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine (Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing.) and the allergic symptoms produced by it.Pharmacokinets of FexofenadineAbsorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. 60-70% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted through urine (10% as unchanged), bile and feces
Onset of Action for FexofenadineN/ADuration of Action for Fexofenadine14 hrsHalf Life of Fexofenadine14.4 hrsSide Effects of Fexofenadine1. Headache
2. Dizziness
3. Drowsiness
4. Back pain
5. Cough
6. NauseaContra-indications of FexofenadineContraindicated in patients with hypersensitivity to the drug or other ingredientsSpecial Precautions while taking Fexofenadine1. Renal dysfunction
2. Any work which require mental alertness like driving and machine operationsPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Fexofenadine1. Hay fever
2. Runny nose
3. Sneezing
4. Tearing eyes
5. HivesInteractions for FexofenadineAn increase in the level of fexofenadine in plasma of 2-times was observed after co-administration of erythromycin or ketoconazole.Typical Dosage for FexofenadineOral-
Adult and children (12yrs)-
Allergic rhinitis:120mg once daily
Allergic skin conditions:180mg once daily
Schedule of FexofenadineN/AStorage Requirements for FexofenadineStore at room temperature and away from excess heat and moistureEffects of Missed Dosage of FexofenadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fexofenadine Give symptomatic and supportive treatment Home Delivery for Montelukast + Fexofenadine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including montelukast + fexofenadine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for montelukast + fexofenadine and other medicines and health products. Home delivery services for montelukast + fexofenadine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take montelukast + fexofenadine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for montelukast + fexofenadine before they complete the sale. You can get this information while placing the order for montelukast + fexofenadine with the pharmacy.
Montelukast + Fexofenadine is a generic medicine name and there are several brands available for it. Some of the brands for montelukast + fexofenadine might be better known than montelukast + fexofenadine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have montelukast + fexofenadine in stock, you can ask for one of the branded alternatives for montelukast + fexofenadine.