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- Pharmacology For Clindamycin + Allantoin + Nicotinamide
Clindamycin + Allantoin + Nicotinamide Pharmacology
Clindamycin + Allantoin + Nicotinamide
About Clindamycin + Allantoin + NicotinamideN/AMechanism of Action of Clindamycin + Allantoin + NicotinamideClindamycin is a lincosamide antibiotic with a primarily bacteriostatic action against Gram-positive aerobes and a wide range of anaerobic bacteria. Nicotinamide is one of the principle form of B-Complex Vitamin (Vitamin B3) with anti-inflammatory activity. It reduces acne lesions, pustules, papules and acne severity. Its special base of allantoin keeps the skin moisturiser and smooth.Pharmacokinets of Clindamycin + Allantoin + NicotinamideN/AOnset of Action for Clindamycin + Allantoin + NicotinamideN/ADuration of Action for Clindamycin + Allantoin + NicotinamideN/AHalf Life of Clindamycin + Allantoin + NicotinamideN/ASide Effects of Clindamycin + Allantoin + NicotinamideN/AContra-indications of Clindamycin + Allantoin + NicotinamideN/ASpecial Precautions while taking Clindamycin + Allantoin + NicotinamideAvoid contact with eye.Pregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Clindamycin + Allantoin + NicotinamideManagement of mil to moderate acne vulgaris and reduction of inflammatory acne lesions.Interactions for Clindamycin + Allantoin + NicotinamideN/ATypical Dosage for Clindamycin + Allantoin + NicotinamideApply to the affected area two times a day,wash affected area before use.Schedule of Clindamycin + Allantoin + NicotinamideN/AStorage Requirements for Clindamycin + Allantoin + NicotinamideN/AEffects of Missed Dosage of Clindamycin + Allantoin + NicotinamideN/AEffects of Overdose of Clindamycin + Allantoin + NicotinamideN/AClindamycin
About ClindamycinMacrolide, Lincosamide Antibiotic.Mechanism of Action of ClindamycinIt binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie:they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis. Along with Quinine sulfate, Clindamycin is used in the treatment of Chloroquine resistant falciparum malaria.Pharmacokinets of ClindamycinAbsorption: It is well absorbed after oral administration.Distribution: It is very widely distributed in the body as protein bound form.Metabolism: Small amount is metabolized in the liver to inactive compound.Excretion: The drug is excreted through urine and small amount through bile and breast milk.Onset of Action for ClindamycinWith in minutesDuration of Action for Clindamycin6 hourHalf Life of Clindamycin3 hourSide Effects of Clindamycin1.Abdominal pain
2.Nausea
3.Vomiting
4.Diarrhoea
5.Pseudomembrnous colitis
6.Urticaria
7.Rash
8.Dermatitis
9.Anaphylaxis
10.Leucopenia
11.EosinophiliaContra-indications of Clindamycin1.Hypersensitive to Clindamycin
2.Ulcerative colitisSpecial Precautions while taking Clindamycin1.Hepatic dysfunction
2.Renal impairment
3.Asthma
4.AllergyPregnancy Related InformationContra indicatedOld Age Related InformationUse with caution.Breast Feeding Related InformationContra indicatedChildren Related InformationUse with caution.Indications for Clindamycin1 Intra abdominal abscess
2.Lung abscess
3.Acne
4.Toxoplasmosis
5.Peritonitis
6.Endocarditis
7.Malaria
8.Empyema
9.Skin and soft tissue infection
10.Bacterial vaginosisInteractions for ClindamycinNeuromuscular blocking agents: Efficacy of these agents (e.g. tubocurarine) enhanced.
Cholinergics: Effects of neostigmine and pyridostigmine antagonised.
Erythromycin: AntagonismTypical Dosage for ClindamycinAdult: 150 - 300 mg four times daily
Severe infection: 300 - 450 mg four times daily
Malaria: 450 mg 3 times daily for 7 days in a regimen with quinine sulfate
Bacterial vaginosis: 300mg twice daily for 7 days
Children:8 - 16 mg / kg body weight/day in 3 - 4 divided dose
Severe infection: 16 - 20 mg/ kg body weight/ day in 3 - 4 divided dose
Schedule of ClindamycinHStorage Requirements for ClindamycinThe drug should be store at room temperature.Effects of Missed Dosage of ClindamycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of ClindamycinGive supportive measures and symptomatic treatment.Allantoin
About AllantoinSkin-softening (keratolytic), cell-proliferating healing agent, abrasive and astringent agent.Mechanism of Action of AllantoinAllantoin works by slowing bacterial growth and loosing and softening scales and crust.The keratolytic effect and abrasive and astringent properties of Allantoin are used in skin softening cosmetic preparations.
Allantoin is a moisturizing, soothing, healing, anti-irritating, keratolytic and non-toxic agent. Allantoin is a cell-proliferating healing agent which stimulates healthy tissue formation. It removes necrotic and scaling tissuePharmacokinets of AllantoinN/AOnset of Action for AllantoinN/ADuration of Action for AllantoinN/AHalf Life of AllantoinN/ASide Effects of Allantoin1.Rash
2.Itchy skinContra-indications of Allantoin1.Hypersensitivity to Allantoin
2.Persons allergy to sunlightSpecial Precautions while taking Allantoin1.For external use only
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Allantoin1.Heal wounds
2.Relieving itching, skin irritations, scaling, dryness, and flaking of the skin due to dandruff, eczema, psoriasis, and seborrhea
3.Stimulate growth of healthy tissue
Interactions for AllantoinN/ATypical Dosage for AllantoinApply the medicament to the affected area 2 - 3 times daily.Schedule of AllantoinN/AStorage Requirements for AllantoinStore at room temperature. Keep out of the reach of children.Effects of Missed Dosage of AllantoinApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule.Effects of Overdose of AllantoinGive supporive measures and symptomatic treatment.Nicotinamide
About NicotinamideWater Soluble Vitamin(B complex- vitamin B3), Amide of nicotinic acid.Mechanism of Action of NicotinamideNicotinamide exerts its action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.Pharmacokinets of NicotinamideAbsorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.Onset of Action for NicotinamideN/ADuration of Action for NicotinamideN/AHalf Life of NicotinamideN/ASide Effects of Nicotinamide1.Activation of peptic ulcer
2.Nausea
3.Vomiting
4.Diarrhoea
5.Headache
6.Hypotension
7.Arrhythmias
8.Hepatic impairment
Contra-indications of Nicotinamide1.Hypersensitivity to the drug
2.Hepatic impairment
3.Peptic ulcer
4.Severe hypotension
5.Arterial haemorrhage
Special Precautions while taking Nicotinamide1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Nicotinamide1.Pellagra
2.Niacin deficiency
3.Hartnup disease
Interactions for NicotinamideN/ATypical Dosage for NicotinamidePellagra: 200 to 500mg daily in divided doses.
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of NicotinamideN/AStorage Requirements for NicotinamideStore at controlled room temperature at a range of 15 to 30 degree C.Effects of Missed Dosage of NicotinamideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of NicotinamideProvide supportive measures and symptomatic treatment.Home Delivery for Clindamycin + Allantoin + Nicotinamide in Your City
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