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- Pharmacology For Povidone Iodine + Ornidazole
Povidone Iodine + Ornidazole Pharmacology
Povidone Iodine + Ornidazole
About Povidone Iodine + OrnidazoleN/AMechanism of Action of Povidone Iodine + OrnidazoleN/APharmacokinets of Povidone Iodine + OrnidazoleN/AOnset of Action for Povidone Iodine + OrnidazoleN/ADuration of Action for Povidone Iodine + OrnidazoleN/AHalf Life of Povidone Iodine + OrnidazoleN/ASide Effects of Povidone Iodine + OrnidazoleN/AContra-indications of Povidone Iodine + OrnidazoleN/ASpecial Precautions while taking Povidone Iodine + OrnidazoleN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Povidone Iodine + Ornidazole1.Burns
2.Ulcers
3.Wounds
4.Cutaneous candidiasis
5.Skin infection
6.Vaginal infection
7.Pre-operative handsrubs
8.Operation site preparation
Interactions for Povidone Iodine + OrnidazoleN/ATypical Dosage for Povidone Iodine + OrnidazoleN/ASchedule of Povidone Iodine + OrnidazoleN/AStorage Requirements for Povidone Iodine + OrnidazoleN/AEffects of Missed Dosage of Povidone Iodine + OrnidazoleN/AEffects of Overdose of Povidone Iodine + OrnidazoleN/APovidone Iodine
About Povidone IodineIodine preparation, External broad microbicidal spectrum antiseptic.Mechanism of Action of Povidone IodinePovidone iodine is an iodophore antiseptic and is a microbicidal drug. It releases iodine from its complex and produces pharmacological actions. The released iodine produces antiseptic actions. Iodine is highly reactive with surrounding and has strong oxidizing effect on functional groups of amino acids (-NH 2, -SH etc.), Nucleotides, and fatty acids (double bond of unsaturated fatty acids). Interaction of Iodine with these groups in a cell results in disintegration of the cytoplasm, enzyme denaturation, loss of integrity in the bacterial cell membrane and fungal cell wall .These will leads to destruction of microbial protein and DNA and finally kills the microbes.Pharmacokinets of Povidone IodineAbsorption: It is poorly absorbed through intact skin but absorption is enhanced through denuded skin.Onset of Action for Povidone IodineImmediate.Duration of Action for Povidone IodineN/AHalf Life of Povidone IodineN/ASide Effects of Povidone Iodine1.Local irritation
2.Rashes
3.Itching
Contra-indications of Povidone Iodine1. Hypersensitivity to Povidone iodine and other preparations containing iodine
2. Thyroid disorders - goiter, hypothyroidism
3. Application to large areas of skin
4. Patient on Lithium therapy
Special Precautions while taking Povidone Iodine1. Hepatic impairment
2. If irritation or redness develops stop the drug use
3. Avoid contact with eyes
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
Below 2 years: contraindicated
NEONATES: contraindicatedIndications for Povidone IodineAs antiseptic in
1. Boils
2. Furunculosis
3. Burns
4. Ulcers
5. Otitis externa
6. Tinea infestations
7. Wound infections
8. Post surgical dressings
9. Cutaneous candidiasis
10. Trichomoniasis
11. Vaginal candidiasis
12. Oral candidiasis
13. Oral hygiene
Interactions for Povidone IodineLab tests: May interfere with thyroid function tests.Typical Dosage for Povidone IodineTopical
Adult:
Ointment (5% w/w Povidone iodine), Cream (5% w/w Povidone iodine). Spray(5 - 10 % w / v Povidone iodine solution), Solution (5 - 7.5 % w/ v Povidone iodine solution) and Powder( 5% w/w Povidone iodine)
Thoroughly clean and dry the area. Apply the drug. Cover with a bandage.
Gargle solution:
Oral candidiasis: 1% mouthwash solution rinse mouth with this solution
Oral hygiene: 0.1 % of 10 ml solution (undiluted or diluted with equal quantity of warm water solution) rinse mouth with this for 30 seconds 4 times daily for 2 weeks
Surgical scrub: 7.5 % w/v solution
Wet hands with water. Pour about 1 teaspoonful of Scrub on the palm of the hand and spread over both hands and
scrub thoroughly for about 5 minutes.
Use a brush if desired. Clean thoroughly under fingernails.
Add a little water and develop copious suds. Rinse thoroughly under running water.
Repeat the entire procedure.
Pessaries:
Vaginal candidiasis: 200 mg as pessaries. Insert 2 pessaries in vagina at night and continue for 2 weeks
Schedule of Povidone IodineN/AStorage Requirements for Povidone IodineStore in a cool dry place. Protect from direct light and heat. Keep out of reach of childrenEffects of Missed Dosage of Povidone IodineApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Povidone IodineGive supportive measures and symptomatic treatment.Ornidazole
About OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. Home Delivery for Povidone Iodine + Ornidazole in Your City
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