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- Pharmacology For Cefalexin + Bromhexine
Cefalexin + Bromhexine Pharmacology
Cefalexin + Bromhexine
About Cefalexin + BromhexineN/AMechanism of Action of Cefalexin + BromhexineN/APharmacokinets of Cefalexin + BromhexineN/AOnset of Action for Cefalexin + BromhexineN/ADuration of Action for Cefalexin + BromhexineN/AHalf Life of Cefalexin + BromhexineN/ASide Effects of Cefalexin + BromhexineN/AContra-indications of Cefalexin + BromhexineN/ASpecial Precautions while taking Cefalexin + BromhexineN/APregnancy Related InformationContraindicated; since Cephalexine is contraindicated in pregnancy. So the combination generic cannot be used in pregnancyOld Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Cephalexine is contraindicated in breast feeding, the combination generic cannot be used in breast feedingChildren Related InformationN/AIndications for Cefalexin + BromhexineIt is a combination of first generation Cephalexin and Expectorant and mucolytic Bromhexine.
1.Surgical procedures done during broncho pulmonary complications
2.Respiratory tract infections
Interactions for Cefalexin + BromhexineN/ATypical Dosage for Cefalexin + Bromhexine1 tablet to be taken three or four times daily.Each tablet contains Cephalexin 250mg & Bromhexine 4mgSchedule of Cefalexin + BromhexineN/AStorage Requirements for Cefalexin + BromhexineN/AEffects of Missed Dosage of Cefalexin + BromhexineN/AEffects of Overdose of Cefalexin + BromhexineN/ACefalexin
About CefalexinA first-generation cephalosporin antibiotic.Mechanism of Action of CefalexinCephalexin is a 1st generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cephalexin inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cephalexin
Pharmacokinets of CefalexinAbsorption: well absorbed orally, food delays absorption, Distribution: widely distributed, Metabolism: not metabolized, Excretion: excreted mainly through urine; & small amount is excreted in breast milkOnset of Action for CefalexinWithin 1hourDuration of Action for CefalexinUp to 12 hoursHalf Life of CefalexinN/ASide Effects of Cefalexin1.Nausea
2.Vomiting
3.Diarrhea
4.Gastritis
5.Super infections
6.Candidiasis
7.Rash & hypersensitivity reactions
8.Joint pain
9.Vaginitis
10.Neutropenia
11.Tthrombocytopenia
12.Headache
13.Dizziness
14.Hallucinations
15.Nephritis
16.Elevated liver enzymes
Contra-indications of Cefalexin1.Hypersensitivity to cephalosporins
2.Porphyria
3.Neuromuscular disorders.
Special Precautions while taking Cefalexin1.Renal impairment
2.Those allergic to penicillins
3. Neuromuscular disorders
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Cefalexin1.Respiratory tract infections
2.Urinary tract infections
3.Surgical prophylaxis
4.Skin infections`
5.Joint & bone infections
6.Otitis media`
7.Reproductive tract infections`
Interactions for CefalexinProbenecid: Excretion of cephalexin reduced.
Aminoglycosides: Enhance half-life and potentiate nephrotoxicity.Typical Dosage for CefalexinAdults: 0 .25 to 1gm orally three times daily or four times daily
Children: 25 to 100mg/kg/day orally four times daily
Infections caused by susceptible organisms:
Adults: 0.25 to 1gm orally four times daily
Children: 25 to 50mg/kg/day orally four times daily
Otitismedia:
Adults: 0.25 to 1gm orally four times daily
Children:75 to 100 mg/kg/day four times daily
Schedule of CefalexinHStorage Requirements for CefalexinStore in a cool place.Effects of Missed Dosage of CefalexinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CefalexinSymptoms of over dosage include neuromuscular disorders & some times seizure may get precipitated. Treatment includes removal of drug from the body by dialysis & supportive measuresBromhexine
About BromhexineMucolytic (secretolytic)Mechanism of Action of BromhexineBromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.Pharmacokinets of BromhexineAbsorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.Onset of Action for BromhexineN/ADuration of Action for BromhexineN/AHalf Life of Bromhexine12hours.Side Effects of Bromhexine1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.Contra-indications of BromhexineHypersensitivity to the drug.Special Precautions while taking Bromhexine1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Bromhexine1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.Interactions for BromhexineN/ATypical Dosage for BromhexineOral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of BromhexineHStorage Requirements for BromhexineStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of BromhexineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BromhexineProvide symptomatic treatment and supportive measures.Home Delivery for Cefalexin + Bromhexine in Your City
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Cefalexin + Bromhexine is a generic medicine name and there are several brands available for it. Some of the brands for cefalexin + bromhexine might be better known than cefalexin + bromhexine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cefalexin + bromhexine in stock, you can ask for one of the branded alternatives for cefalexin + bromhexine.