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- Pharmacology For Vitamin A + Zinc Sulphate
Vitamin A + Zinc Sulphate Pharmacology
Vitamin A + Zinc Sulphate
About Vitamin A + Zinc SulphateN/AMechanism of Action of Vitamin A + Zinc SulphateZinc deficiency limits the bioavailability of vitamin A. Because zinc and vitamin A deficiency often coexist in malnourished children, simultaneous zinc and vitamin A supplementation may improve the vitamin A deficiency in these children.Pharmacokinets of Vitamin A + Zinc SulphateN/AOnset of Action for Vitamin A + Zinc SulphateN/ADuration of Action for Vitamin A + Zinc SulphateN/AHalf Life of Vitamin A + Zinc SulphateN/ASide Effects of Vitamin A + Zinc SulphateN/AContra-indications of Vitamin A + Zinc SulphateN/ASpecial Precautions while taking Vitamin A + Zinc SulphateN/APregnancy Related InformationUse with cautionOld Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Vitamin A + Zinc SulphateZinc and Vitamin A deficiencyInteractions for Vitamin A + Zinc SulphateN/ATypical Dosage for Vitamin A + Zinc SulphateN/ASchedule of Vitamin A + Zinc SulphateN/AStorage Requirements for Vitamin A + Zinc SulphateN/AEffects of Missed Dosage of Vitamin A + Zinc SulphateN/AEffects of Overdose of Vitamin A + Zinc SulphateN/AVitamin A
About Vitamin AFat-soluble vitamin, Treatment of vitamin A deficiency.Mechanism of Action of Vitamin AVitamin A is required for a variety of physiological functions in the body such as: - 1).Proper functioning of retina and formation of pigment Rhodopsin during dark adaptation. 2).promotes differentiation and maintains structural integrity of epithelia over the body and also retard the malignancies of epithelial structures.3).Promotes mucous secretion. 4).Inhibits keratinization, 5). Maintains proper bone growth, 6).Maintenance of spermatogenesis, 7).Supports foetal development, 8).Improves resistance to infection. It is required for proper antibody response, normal lymphocyte proliferation and killer cell function.Pharmacokinets of Vitamin AAbsorption: Completely absorbed normally. Steatorrhoea, bile deficiency, and protein poor diet adversely affects the absorption and absorption requires bile salts, pancreatic lipase, and dietary fat.
Distribution: Stored primarily as palmitate in kupffer`s cells in liver. Circulates in the form of specific alpha-1 protein; retinol binding protein and transported to cellular retinol binding protein of target cells.
Metabolism: Metabolized in the liver.
Excretion: Excreted mainly through bile and a small amount is excreted through urine.
Onset of Action for Vitamin AN/ADuration of Action for Vitamin AN/AHalf Life of Vitamin AN/ASide Effects of Vitamin AAdverse effects occurs only with higher doses and toxicity
1. Nausea
2. Vomiting
3. Itching
4. Dermatitis
5. Exfoliation
6. Alopecia
7. Bone and joint pain
8. Anorexia
9. Irritability
10. Increased intracranial pressure
11. Hepatic impairment
12. Anaphylactic shock
Contra-indications of Vitamin A1. Hypervitaminosis A
2. Hypersensitivity to the vitamin A
Special Precautions while taking Vitamin A1. Oral form should not use in patients with malabsorption syndrome.
2. In inadequate bile secretion oral route may be used with concurrent administration of bile salts.
3. I. V. route is contraindicated except for special water miscible forms intended for infusion with large parenteral volumes and should not use I. V. push of vitamin A of any type.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Vitamin A1. Vitamin A deficiency
2. Xerophthalmia
3. Acne
4. Ichthyosis
5. Bitot`s spots
6. Night blindness
Interactions for Vitamin ACholestyramine: Absorption of Vitamin A is reduced due to reduced availability of fat stabilizing bile salts.
Mineral oil: Interferes with intestinal absorption of Vitamin A.
Oral Contraceptives: Plasma Vitamin A levels are significantly increased.Typical Dosage for Vitamin ASevere vitamin A deficiency with xerophthalmia: 500000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Severe vitamin A deficiency: 100000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Children: 5000 to 10000 IU daily for 14 days.
Schedule of Vitamin AC1 (Oral)
C (Parenteral)
Storage Requirements for Vitamin AStore in a well closed, airtight container in a cool dry place.Effects of Missed Dosage of Vitamin ATake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin ADiscontinue the vitamin A if hypercalcaemia persists and administer I.V. saline, prednisolone, and calcitonin if required. Monitor hepatic function tests to detect liver damage. Zinc Sulphate
About Zinc SulphateZinc compound, An astringent , Adjunctive treatment of Wilson?s disease.Mechanism of Action of Zinc SulphateN/APharmacokinets of Zinc SulphateN/AOnset of Action for Zinc SulphateN/ADuration of Action for Zinc SulphateN/AHalf Life of Zinc SulphateN/ASide Effects of Zinc SulphateN/AContra-indications of Zinc SulphateN/ASpecial Precautions while taking Zinc SulphateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Zinc SulphateN/AInteractions for Zinc SulphateN/ATypical Dosage for Zinc SulphateN/ASchedule of Zinc SulphateN/AStorage Requirements for Zinc SulphateN/AEffects of Missed Dosage of Zinc SulphateN/AEffects of Overdose of Zinc SulphateN/AHome Delivery for Vitamin A + Zinc Sulphate in Your City
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