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- Pharmacology For Mecobalamin + Alpha- Lipoic Aicd
Mecobalamin + Alpha- Lipoic Aicd Pharmacology
Mecobalamin + Alpha- Lipoic Aicd
About Mecobalamin + Alpha- Lipoic AicdN/AMechanism of Action of Mecobalamin + Alpha- Lipoic AicdN/APharmacokinets of Mecobalamin + Alpha- Lipoic AicdN/AOnset of Action for Mecobalamin + Alpha- Lipoic AicdN/ADuration of Action for Mecobalamin + Alpha- Lipoic AicdN/AHalf Life of Mecobalamin + Alpha- Lipoic AicdN/ASide Effects of Mecobalamin + Alpha- Lipoic AicdN/AContra-indications of Mecobalamin + Alpha- Lipoic AicdN/ASpecial Precautions while taking Mecobalamin + Alpha- Lipoic AicdN/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Mecobalamin + Alpha- Lipoic Aicd1.Peripheral neuropathy
2.Diabetic neuropathy
3.Megaloblastic anaemia
Interactions for Mecobalamin + Alpha- Lipoic AicdN/ATypical Dosage for Mecobalamin + Alpha- Lipoic AicdN/ASchedule of Mecobalamin + Alpha- Lipoic AicdN/AStorage Requirements for Mecobalamin + Alpha- Lipoic AicdN/AEffects of Missed Dosage of Mecobalamin + Alpha- Lipoic AicdN/AEffects of Overdose of Mecobalamin + Alpha- Lipoic AicdN/AMecobalamin
About MecobalaminWater soluble, Form of Vitamin B12Mechanism of Action of MecobalaminMecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.Pharmacokinets of MecobalaminAbsorption: Absorbed after oral, sublingual, injection
Excretion: Excretion via urine
Onset of Action for MecobalaminN/ADuration of Action for MecobalaminN/AHalf Life of MecobalaminN/ASide Effects of Mecobalamin1.Oral: Anorexia, nausea, vomiting and diarrhea
2.Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site
Contra-indications of MecobalaminN/ASpecial Precautions while taking MecobalaminN/APregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationN/AIndications for Mecobalamin1.Peripheral neuropathies
2.Megaloblastic anaemia
Interactions for Mecobalamin1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines
2.Reduced serum concentrations with oral contraceptives
3.Reduced effects in anaemia with parenteral chloramphenicol
Typical Dosage for MecobalaminPeripheral neuropathies
Oral: Adult: 1500 mcg/day in 3 divided doses
Parenteral: 500 mcg daily IM/IV 3 times/wk
Megaloblastic anaemia caused by vitamin B12 deficiency
Parenteral: Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.Schedule of MecobalaminN/AStorage Requirements for MecobalaminOral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Effects of Missed Dosage of MecobalaminN/AEffects of Overdose of MecobalaminN/AAbout N/AMechanism of Action of N/APharmacokinets of N/AOnset of Action for N/ADuration of Action for N/AHalf Life of N/ASide Effects of N/AContra-indications of N/ASpecial Precautions while taking N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for N/AInteractions for N/ATypical Dosage for N/ASchedule of N/AStorage Requirements for N/AEffects of Missed Dosage of N/AEffects of Overdose of N/AHome Delivery for Mecobalamin + Alpha- Lipoic Aicd in Your City
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