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- Pharmacology For Mebeverine + Alprazolam
Mebeverine + Alprazolam Pharmacology
Mebeverine + Alprazolam
About Mebeverine + AlprazolamN/AMechanism of Action of Mebeverine + AlprazolamN/APharmacokinets of Mebeverine + AlprazolamN/AOnset of Action for Mebeverine + AlprazolamN/ADuration of Action for Mebeverine + AlprazolamN/AHalf Life of Mebeverine + AlprazolamN/ASide Effects of Mebeverine + AlprazolamN/AContra-indications of Mebeverine + AlprazolamN/ASpecial Precautions while taking Mebeverine + AlprazolamN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with caution Breast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Mebeverine + Alprazolam1.Irritable bowel syndrome
2.GI tract spasm
Interactions for Mebeverine + AlprazolamN/ATypical Dosage for Mebeverine + AlprazolamN/ASchedule of Mebeverine + AlprazolamN/AStorage Requirements for Mebeverine + AlprazolamN/AEffects of Missed Dosage of Mebeverine + AlprazolamN/AEffects of Overdose of Mebeverine + AlprazolamN/AMebeverine
About MebeverineReserpine derivative, antimuscarinic, a musculotropic antispasmodic, Motility stimulant.Mechanism of Action of MebeverineMebeverine has a direct relaxant effect on smooth muscle. This will inhibits gastrointestinal propulsive motility and gastric acid secretion.Pharmacokinets of MebeverineAbsorption: It is well absorbed after oral administration.
Distribution:
Metabolism: Mebeverine is rapidly and extensively undergoes hydrolysis and forms Veratric acid
Excretion: Metabolites are excreted mainly in urine
Onset of Action for MebeverineN/ADuration of Action for MebeverineN/AHalf Life of Mebeverine1.1 hoursSide Effects of Mebeverine1.Gastrointestinal disturbances
2.Heart burn
3.Dizziness
4.Dyspepsia
Contra-indications of Mebeverine1.Hypersensitivity to MebeverineSpecial Precautions while taking Mebeverine1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Ischemic heart disease
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Mebeverine1.Irritable bowel syndromeInteractions for MebeverineN/ATypical Dosage for MebeverineAdult: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children above 10 years: 405 mg / day in 3- divided doses to be taken 20 minutes before meals. Dose can be gradually reduced after 1 week if sufficient response is obtained.
Children below 10 years: contraindicated.
Schedule of MebeverineHStorage Requirements for MebeverineStore in a cool dry place. Protect from heat and light.
Keep out of the reach of children
Effects of Missed Dosage of MebeverineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of MebeverineGive supportive measures and symptomatic treatment.Alprazolam
About AlprazolamBenzodiazepine derivative, Anti anxiety.Mechanism of Action of AlprazolamAlprazolam mainly acts on Limbic system and ascending reticular formation in the CNS and binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will produce an increase in the concentration of the inhibitory neurotransmitter GABA and increase in chloride ions and decreases firing rate of neuron. This in turn alters normal functions of the body.Pharmacokinets of AlprazolamAbsorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised to active and inactive metabolite in the liver. Excretion: Drug is excreted in urine.Onset of Action for Alprazolam15 - 30 minutesDuration of Action for Alprazolam12 - 16 hoursHalf Life of Alprazolam12 -15 hoursSide Effects of Alprazolam1.Ataxia
2.Drowsiness
3.Light headedness
4. Slurred speech
5.Nausea
6.Constipation or diarrhoea
7.Tremor
8.Dependence
9.Anorexia
0.Confusion
11.Light headedness
12.Mood changes
13.Muscle rigidity
14.AmnesiaContra-indications of Alprazolam1.Hypersensitivity to Benzodiazepines
2.Acute angle closure glaucomaSpecial Precautions while taking Alprazolam1.Renal impairment
2.Hepatic impairment
3.Pulmonary insufficiency
4.Drug abuse
5.Bipolar disorder
6.Driving vehicles and operating machines and people involving any other dangerous activitiesPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES- contraindicated
Indications for Alprazolam1.For the short-term management of anxiety,
2.Treatment of Panic disorder.Interactions for AlprazolamAlcohol & other CNS depressants: Enhanced CNS effects.
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol,
Valproic Acid: Elimination of alprazolam decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs.
Levodopa: Decrease in antiparkinsonism efficacy.
Rifampicine: Decreases efficacy.Typical Dosage for AlprazolamAdult:
Anxiety: 0.25 - 0.5 mg every 8 hours in a day. Depending on the severity of the disease the dose can be gradually increased every 3 or 4 days.
Maximum dose: 4 mg / day in divided dose.
Anxiety with depression: 0.5 mg every 8 hours in a day
Maintenance dose: 1.5 - 4.5 mg/ day in divided dose
Panic disorder: starting dose: 1.5 mg /day in 3 divided dose. Depending on the severity of the disease the dose can be gradually increased every 3 or 4 days.
Children: Not recommended
Schedule of AlprazolamHStorage Requirements for AlprazolamThe drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of AlprazolamTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of AlprazolamGive supportive measures and symptomatic treatment. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.If the patient is conscious induce emesis followed by charcoal administrationHome Delivery for Mebeverine + Alprazolam in Your City
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