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- Pharmacology For Amoxycillin + Bromhexine + Lactobacillus
Amoxycillin + Bromhexine + Lactobacillus Pharmacology
Amoxycillin + Bromhexine + Lactobacillus
About Amoxycillin + Bromhexine + LactobacillusN/AMechanism of Action of Amoxycillin + Bromhexine + LactobacillusN/APharmacokinets of Amoxycillin + Bromhexine + LactobacillusN/AOnset of Action for Amoxycillin + Bromhexine + LactobacillusN/ADuration of Action for Amoxycillin + Bromhexine + LactobacillusN/AHalf Life of Amoxycillin + Bromhexine + LactobacillusN/ASide Effects of Amoxycillin + Bromhexine + LactobacillusN/AContra-indications of Amoxycillin + Bromhexine + LactobacillusN/ASpecial Precautions while taking Amoxycillin + Bromhexine + LactobacillusN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Amoxycillin + Bromhexine + LactobacillusN/AInteractions for Amoxycillin + Bromhexine + LactobacillusN/ATypical Dosage for Amoxycillin + Bromhexine + LactobacillusN/ASchedule of Amoxycillin + Bromhexine + LactobacillusN/AStorage Requirements for Amoxycillin + Bromhexine + LactobacillusN/AEffects of Missed Dosage of Amoxycillin + Bromhexine + LactobacillusN/AEffects of Overdose of Amoxycillin + Bromhexine + LactobacillusN/AAmoxycillin
About AmoxycillinSemisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.Mechanism of Action of AmoxycillinAmoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.Pharmacokinets of AmoxycillinAbsorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin60 -120 minutesDuration of Action for Amoxycillin6-8 hoursHalf Life of Amoxycillin60 minutesSide Effects of Amoxycillin1.Aaphylaxis
2. Vomiting
3.Diarrhoea
4 Nausea
5.Rash
6.Urticaria
7.Thrombocytopenia
8.Nephritis
9.Seizure
10.Super infections.
Contra-indications of AmoxycillinHypersensitivity to Amoxicillin and other Penicillins.Special Precautions while taking Amoxycillin1.Mononucleosis
2.Lymphatic leukaemia
3.HIV infections
4.Hepatic impairment
5.Renal impairment
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Amoxycillin1Urinary tract infections
2.Gonorrhoea
3 Meningitis
4.SABE
5.Respiratory tract infections
6.Septicemia
7.Soft tissue infections
8.Otitis media
9.Sinusitis
10.Tetanus
11.Biliarytract infections
12.Bronchitis
13.Salmonellosis
14.Typhoid
15.Gastroenteritis
16.Chlamydia infection
17.Paratyphoid fever
18.Dental infections
Interactions for AmoxycillinOral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.Typical Dosage for AmoxycillinADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of AmoxycillinHStorage Requirements for AmoxycillinIt should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.Effects of Missed Dosage of AmoxycillinTake the dose as soon as noticed and if it is the time to the next dose then skip the missed doseEffects of Overdose of AmoxycillinGive supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.
Bromhexine
About BromhexineMucolytic (secretolytic)Mechanism of Action of BromhexineBromhexine hydrochloride acts as a mucokinetic and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and network of fibres in tenacious sputum is broken. It induces thin copious bronchial secretion.Pharmacokinets of BromhexineAbsorption: Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and bioavailability is about 20%. Distribution: It is widely distributed to body tissues in a highly protein bound form; Bromhexine crosses the blood brain barrier and small amounts cross the placenta, Metabolism: It undergoes extensive first-pass metabolism in the liver. Excretion: It is excreted primarily in the urine mainly as metabolites.Onset of Action for BromhexineN/ADuration of Action for BromhexineN/AHalf Life of Bromhexine12hours.Side Effects of Bromhexine1 Rhinorrhoea
2 Lacrimations
3.Allergic reactions
4.Gastric irritation.Contra-indications of BromhexineHypersensitivity to the drug.Special Precautions while taking Bromhexine1. Hepatic impairment
2. Renal impairment
3. Gastric and duodenal ulcer
4. Convulsive disorders
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Bromhexine1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10.Chronic Pneumonia.Interactions for BromhexineN/ATypical Dosage for BromhexineOral: 8mg thrice daily.
Children (5 to 10 years): 4mg thrice daily
Children (1 to 5 years): 4mg twice daily.
Schedule of BromhexineHStorage Requirements for BromhexineStore in a cool dry place and protect from light. Keep out of reach of children.Effects of Missed Dosage of BromhexineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of BromhexineProvide symptomatic treatment and supportive measures.Lactobacillus
About LactobacillusLactic acid bacteria, Probiotic,Antidiarrhoeal.Mechanism of Action of LactobacillusLactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.Pharmacokinets of LactobacillusAbsorption: It is orally well absorbed after oral administration.
Onset of Action for LactobacillusN/ADuration of Action for LactobacillusN/AHalf Life of LactobacillusN/ASide Effects of Lactobacillus1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus1.Recent bowel surgery
2.Intestinal damage
3.Weakened immune system
Special Precautions while taking LactobacillusPatient on Inulin treatmentPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: Use with cautionIndications for Lactobacillus1.Aphthous stomatitis
2.Hypochlorhydria
3.Hepatic encephalopathy
4.Adjuvant to antibiotic therapy
5.Diarrhoea.Interactions for LactobacillusN/ATypical Dosage for LactobacillusAdult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Suppositories:
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of LactobacillusN/AStorage Requirements for LactobacillusRefrigerate below 5 degree C.Effects of Missed Dosage of LactobacillusN/AEffects of Overdose of LactobacillusGive supportive measures and symptomatic treatmentHome Delivery for Amoxycillin + Bromhexine + Lactobacillus in Your City
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