Amoxycillin + Clavulanic acid + Lactobacillus Pharmacology

Amoxycillin + Clavulanic acid + Lactobacillus

About Amoxycillin + Clavulanic acid + Lactobacillus
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Mechanism of Action of Amoxycillin + Clavulanic acid + Lactobacillus
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Pharmacokinets of Amoxycillin + Clavulanic acid + Lactobacillus
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Onset of Action for Amoxycillin + Clavulanic acid + Lactobacillus
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Duration of Action for Amoxycillin + Clavulanic acid + Lactobacillus
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Half Life of Amoxycillin + Clavulanic acid + Lactobacillus
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Side Effects of Amoxycillin + Clavulanic acid + Lactobacillus
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Contra-indications of Amoxycillin + Clavulanic acid + Lactobacillus
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Special Precautions while taking Amoxycillin + Clavulanic acid + Lactobacillus
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Amoxycillin + Clavulanic acid + Lactobacillus
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Interactions for Amoxycillin + Clavulanic acid + Lactobacillus
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Typical Dosage for Amoxycillin + Clavulanic acid + Lactobacillus
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Schedule of Amoxycillin + Clavulanic acid + Lactobacillus
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Storage Requirements for Amoxycillin + Clavulanic acid + Lactobacillus
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Effects of Missed Dosage of Amoxycillin + Clavulanic acid + Lactobacillus
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Effects of Overdose of Amoxycillin + Clavulanic acid + Lactobacillus
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Amoxycillin

About Amoxycillin
Semisynthetic Broad spectrum beta-lactam antibiotic, An aminopenicillin Derivative.
Mechanism of Action of Amoxycillin
Amoxycillin is a bactericidal drug. It is a Beta lactum antibiotic. It binds to the Penicillin binding protein in the cell wall of bacteria and inhibits the enzyme transpeptidase which is responsible for the transpeptidation reaction in peptidoglycan synthesis. It also activates the endogenous enzyme which degrades the peptidoglycan.These results in inhibition of protein synthesis and there by cell wall synthesis. Amoxycillin is active against gram positive and gram negative bacteria except penicillinase producing once.
Pharmacokinets of Amoxycillin
Absorption .It is well absorbed after oral administration. Distribution: It is very widely distributed in the body .Metabolism: In significant metabolism. Excretion: It is excreted mainly through urine and small amount excreted
in breast milk
Onset of Action for Amoxycillin
60 -120 minutes
Duration of Action for Amoxycillin
6-8 hours
Half Life of Amoxycillin
60 minutes
Side Effects of Amoxycillin
1.Aaphylaxis
2. Vomiting
3.Diarrhoea
4 Nausea
5.Rash
6.Urticaria
7.Thrombocytopenia
8.Nephritis
9.Seizure
10.Super infections.
Contra-indications of Amoxycillin
Hypersensitivity to Amoxicillin and other Penicillins.
Special Precautions while taking Amoxycillin
1.Mononucleosis
2.Lymphatic leukaemia
3.HIV infections
4.Hepatic impairment
5.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Amoxycillin
1Urinary tract infections
2.Gonorrhoea
3 Meningitis
4.SABE
5.Respiratory tract infections
6.Septicemia
7.Soft tissue infections
8.Otitis media
9.Sinusitis
10.Tetanus
11.Biliarytract infections
12.Bronchitis
13.Salmonellosis
14.Typhoid
15.Gastroenteritis
16.Chlamydia infection
17.Paratyphoid fever
18.Dental infections
Interactions for Amoxycillin
Oral contraceptives: Efficacy reduced, may cause breakthrough bleeding or pregnancy.
Erythromycin, Tetracycline: Reduce efficacy.
Typical Dosage for Amoxycillin
ADULT: 250 - 500 mg three to four times daily.
In severe infections dose can be increased to 3 - 6 g daily depending on the severity of infection.
CHILDREN:125 - 250 mg three to four times a day depending on the severity of infection.
Schedule of Amoxycillin
H
Storage Requirements for Amoxycillin
It should store at temperature below 25 degree C. Keep away from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Amoxycillin
Take the dose as soon as noticed and if it is the time to the next dose then skip the missed dose
Effects of Overdose of Amoxycillin
Give supportive measures and symptomatic treatment. If the patient is conscious induce emesis or gastric lavage followed by charcoal administration. Haemodialysis can be done if needed.

Clavulanic acid

About Clavulanic acid
Beta-Lactamase Inhibitor, Antibiotic resistance reducer to penicillin group.
Mechanism of Action of Clavulanic acid
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Pharmacokinets of Clavulanic acid
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Onset of Action for Clavulanic acid
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Duration of Action for Clavulanic acid
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Half Life of Clavulanic acid
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Side Effects of Clavulanic acid
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Contra-indications of Clavulanic acid
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Special Precautions while taking Clavulanic acid
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Clavulanic acid
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Interactions for Clavulanic acid
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Typical Dosage for Clavulanic acid
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Schedule of Clavulanic acid
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Storage Requirements for Clavulanic acid
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Effects of Missed Dosage of Clavulanic acid
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Effects of Overdose of Clavulanic acid
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Lactobacillus

About Lactobacillus
Lactic acid bacteria, Probiotic,Antidiarrhoeal.
Mechanism of Action of Lactobacillus
Lactobacillus is a probiotic and it is called as friendly bacteria. It is used along with antibiotic in order to restore the body`s natural microbial flora with in the digestive tract. Lactobacillus helps in the breakdown of food and leads to the production of lactic acid, hydrogen peroxide and other byproducts. This will alter the intestinal pH and that make the environment hostile for pathogens.
Pharmacokinets of Lactobacillus
Absorption: It is orally well absorbed after oral administration.
Onset of Action for Lactobacillus
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Duration of Action for Lactobacillus
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Half Life of Lactobacillus
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Side Effects of Lactobacillus
1.Abdominal discomfort
2.Vaginal irritation (when used vaginally)
Contra-indications of Lactobacillus
1.Recent bowel surgery
2.Intestinal damage
3.Weakened immune system
Special Precautions while taking Lactobacillus
Patient on Inulin treatment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: Use with caution
Indications for Lactobacillus
1.Aphthous stomatitis
2.Hypochlorhydria
3.Hepatic encephalopathy
4.Adjuvant to antibiotic therapy
5.Diarrhoea.
Interactions for Lactobacillus
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Typical Dosage for Lactobacillus
Adult: 60 - 150 million spores 3 times daily depending on the severity of infections.
Vaginal bacterial infections: 1- 2 billion bacteria 2 - 3 times daily
Suppositories:
Vaginal infections, cystitis: 1 - 2 suppositories are inserted in to vagina at night for 2 weeks. Each suppository contains 1 - 2 billion lactobacilli
Schedule of Lactobacillus
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Storage Requirements for Lactobacillus
Refrigerate below 5 degree C.
Effects of Missed Dosage of Lactobacillus
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Effects of Overdose of Lactobacillus
Give supportive measures and symptomatic treatment

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