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- Pharmacology For Ketorolac + Ofloxacin + Hydroxypropyl Methyl Cellulose
Ketorolac + Ofloxacin + Hydroxypropyl Methyl Cellulose Pharmacology
Ketorolac + Ofloxacin + Hydroxypropyl Methyl Cellulose
About Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AMechanism of Action of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/APharmacokinets of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AOnset of Action for Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/ADuration of Action for Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AHalf Life of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/ASide Effects of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AContra-indications of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/ASpecial Precautions while taking Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated in children younger than 3 years oldIndications for Ketorolac + Ofloxacin + Hydroxypropyl Methyl Cellulose1.Seasonal Allergic Conjunctivitis .
2.To prevent ocular itching.
3.Post operative ocular inflammation and pain.
4.To reduce Bacterial Keratitis
Interactions for Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/ATypical Dosage for Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseOne drop of ophthalmic solution should be applied to the affected eye(s) four times daily beginning 24 hours after cataract surgery and continuing through the first 2 weeks of the post-operative period.
Schedule of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AStorage Requirements for Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AEffects of Missed Dosage of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AEffects of Overdose of Ketorolac + Ofloxacin + Hydroxypropyl Methyl CelluloseN/AKetorolac
About KetorolacNSAID, heterocyclic acetic acid derivative, Analgesic,antipyretic,antiinflammatory.Mechanism of Action of KetorolacThis Non Steroidal Anti Inflammatory Drug`s peripheral analgesics action is by the reduction of the prostaglandin synthesis which mediates many of the inflammatory changes and fever at that time. Prostaglandin synthesis is reduced due to its cyclo oxygenase inhibition. At higher concentration it reduce production of super oxide radicals, induce apoptosis, inhibit the expression of adhesion molecules, decrease nitric oxide synthase , reduce pro inflammatory cytokines, modify lymphocyte activity, and alter cellular membrane functions.Pharmacokinets of KetorolacAbsorption-Absorbed rapidly after oral, i.v. and i.m. administration.
Distribution- Widely distributed in the body. 99% bound to the plasma proteins.
Metabolism- It is metabolized in liver by glucucoronidation.
Excretion-90% is excreted through urine and rest in feces. The rate of elimination is reduced in the elderly and in patients with renal failure.
Onset of Action for KetorolacFor I.V. there is rapid onset of action
In the case of I.M. it takes 10 minutes
After oral administration it takes ? to 1 hr
Duration of Action for Ketorolac6 to 8 hrsHalf Life of Ketorolac5 - 7 hrsSide Effects of Ketorolac1. Nausea
2. Drowsiness
3. Dizziness
4. Headache
5. Syncope
6. Transient scalp tingling
7. Orthostatic hypotension
8. Ventricular arrhythmias
9. Nasal stuffiness
10. Broncho spasm
11. Vomiting
12. Diarrhea
13. Muscle spasm
14. Toxic myopathy
15. Dry mouth
16. Ulcer
17. Gastric irritation
18. Oedema
19. Dry mouth
Contra-indications of Ketorolac1. Hypersensitivity to this drug
2. Peptic ulcer
3. As a prophylactic analgesic before surgery; pregnancy and lactation
5. In elderly patient there is usually hepatic or renal dysfunction
6. Coagulation disorder
Special Precautions while taking Ketorolac1. Hepatic dysfunction
2. Renal dysfunction and in to be used with caution
3. GI disease
4. Bleeding disorders
5. Patients with hypersensitivity to other Non Steroidal Anti Inflammatory Drugs
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Ketorolac1. It is used to severe and moderate pain frequently in post operative and acute musculoskeletal pain
2. For routine obstetrics analgesia
3. For renal colic, migraine and pain due to bony metastasis
4. Migraine
5. Acute gout
Interactions for KetorolacAnticoagulants: May prolong prothrombin time.
Beta blockers: Antihypertensive effect may be impaired.
Cyclosporine: Nephrotoxicity of both agents may be increased.
Lithium: Serum lithium levels may be increased resulting in toxicity.
Hydantoins: Serum hydantoins levels resulting in increased efficacy and toxic effects.
Methotrexate: Risk of methotrexate toxicity (stomatitis, bone marrow suppression, nephrotoxicity) increased.
Aspirin: Plasma concentration of ketorolac may be decreased and may increase the incidence of GI effects.Typical Dosage for KetorolacFor Injection-
Adults-Initially 60mg i.m. or 30mg i.v. as a single dose, or 30 mg i.m or i.v. every 6 hrs. In the case of renal impaired patient, initially 30mg i.m .or 15mg i.v. as a single doses or multiple doses of 15mg i.m. or i.v.every 6 hrs.
For oral-
Adults- 20mg as a single dose followed by 10mg every 4 to 6 hrs. In the case of renal impaired patients 10mg as a single dose, followed by 10mg every 4 to 6 hrs.
Schedule of KetorolacHStorage Requirements for KetorolacStore at controlled room temperature.Effects of Missed Dosage of KetorolacTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of KetorolacTake more fluids to dilute the over dosage. Give symptomatic and supportive treatment.Ofloxacin
About OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Constipation
6. Dry mouth
7. Dizziness
8. Headache
9. Rash
10. Pruritis
11. Pseudomembranous colitis
12. Visual disturbances
13. Insomnia
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
4. Epilepsy
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
2. Pneumonia
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
6. Gonorrhoea
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
10. Prostatis
11. Otitis
12. Gynaecological infections
13. Conjunctivitis
14. Keratitis
15. Urethritis
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done. Hydroxypropyl Methyl Cellulose
About Hydroxypropyl Methyl CelluloseA semisynthetic, inert, viscoelastic polymer, Ophthalmic lubricant ,Artificial tears.Mechanism of Action of Hydroxypropyl Methyl CelluloseHydroxy Propyl methylcellulose belongs to the group of medicines known as artificial tears. Artificial tears are used to treat the keratoconjunctivitis sicca (dryness) and irritation in the eye. They are also used to moisten contact lenses and in eye examinations. These moisten lenses and remove particulate matter that causes irritation.
The surface active properties of the Hydroxy Propyl methyl cellulose (vehicles) found in artificial tears solutions act to stabilize the tear film and increase tear viscosity to prevent tear evaporation and retard tear drainage. The vehicles found in bland lubricant artificial tear ointments also enhance the tear film and additionally have a prolonged duration of action in the eye versus artificial tear solutions.
It is used to relieve dryness and irritation caused by reduced tear flow. It helps prevent damage to the eye in certain eye diseases. Hydroxy Propyl methylcellulose may also be used to moisten hard contact lenses and artificial eyes. In addition, it may be used in certain eye examinations
Pharmacokinets of Hydroxypropyl Methyl CelluloseN/AOnset of Action for Hydroxypropyl Methyl CelluloseN/ADuration of Action for Hydroxypropyl Methyl CelluloseN/AHalf Life of Hydroxypropyl Methyl CelluloseN/ASide Effects of Hydroxypropyl Methyl Cellulose1.Eye irritation
2.Stickiness of eyelashes
3.Blurred vision
4.Redness of eyes
Contra-indications of Hydroxypropyl Methyl CelluloseN/ASpecial Precautions while taking Hydroxypropyl Methyl Cellulose1.Eye pain
2.Changes in vision
3.Continued redness or irritation of the eye
4.Excessive tearing or if symptoms continue for more than 3 days or become worse consult doctor.
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be used
NEONATES: may be used
Indications for Hydroxypropyl Methyl CelluloseAid in anterior surgical preparations:
1.Cataract surgery
2.Intraocular lens implantation
3.Diagnostic aid in Gonioscopy
4.In keratoplasty
5.Diagnostic aid in contact lens procedures
6.Artificial tear
7.Lubricant in ophthalmic preparations
8.Protectant in ophthalmic preparations
9.Moistening of daily wear soft lenses
Interactions for Hydroxypropyl Methyl CelluloseN/ATypical Dosage for Hydroxypropyl Methyl CelluloseDOSAGE: Hydroxy Propyl methylcellulose (HPMC) 0.3% is used
For dry eyes:
Adults and children-Instill 1 drop 3 -4 times a day. Dose is depending on the patient`s response
Schedule of Hydroxypropyl Methyl CelluloseN/AStorage Requirements for Hydroxypropyl Methyl CelluloseStore at room temperature. Keep in a tightly closed container. Keep out of the reach of childrenEffects of Missed Dosage of Hydroxypropyl Methyl CelluloseInstill the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Hydroxypropyl Methyl CelluloseGive supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.Home Delivery for Ketorolac + Ofloxacin + Hydroxypropyl Methyl Cellulose in Your City
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Ketorolac + Ofloxacin + Hydroxypropyl Methyl Cellulose is a generic medicine name and there are several brands available for it. Some of the brands for ketorolac + ofloxacin + hydroxypropyl methyl cellulose might be better known than ketorolac + ofloxacin + hydroxypropyl methyl cellulose itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ketorolac + ofloxacin + hydroxypropyl methyl cellulose in stock, you can ask for one of the branded alternatives for ketorolac + ofloxacin + hydroxypropyl methyl cellulose.