Levofloxacin + Ambroxol Pharmacology

Levofloxacin + Ambroxol

About Levofloxacin + Ambroxol

N/A

Mechanism of Action of Levofloxacin + Ambroxol

N/A

Pharmacokinets of Levofloxacin + Ambroxol

N/A

Onset of Action for Levofloxacin + Ambroxol

N/A

Duration of Action for Levofloxacin + Ambroxol

N/A

Half Life of Levofloxacin + Ambroxol

N/A

Side Effects of Levofloxacin + Ambroxol

N/A

Contra-indications of Levofloxacin + Ambroxol

N/A

Special Precautions while taking Levofloxacin + Ambroxol

N/A

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Levofloxacin + Ambroxol

To treat severe or life-threatening bacterial infections or bacterial infections which have failed to respond to other antibiotic classes of Respiratory tract.

Interactions for Levofloxacin + Ambroxol

N/A

Typical Dosage for Levofloxacin + Ambroxol

N/A

Schedule of Levofloxacin + Ambroxol

N/A

Storage Requirements for Levofloxacin + Ambroxol

N/A

Effects of Missed Dosage of Levofloxacin + Ambroxol

N/A

Effects of Overdose of Levofloxacin + Ambroxol

N/A

Levofloxacin

About Levofloxacin

Third generation fluoroquinolone (or quinolone), A broad spectrum antiinfective.

Mechanism of Action of Levofloxacin

Levofloxacin is a broad spectrum antibacterial agent. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Levofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.

Pharmacokinets of Levofloxacin

Absorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism in the liver. Excretion: Drug is excreted mainly through urine.

Onset of Action for Levofloxacin

N/A

Duration of Action for Levofloxacin

N/A

Half Life of Levofloxacin

6 - 8 hour

Side Effects of Levofloxacin

1. Nausea
2. Vomiting
3. Diarrhoea
4. Abdominal discomfort
5. Restlessness
6. Dizziness
7. Drowsiness
8. Arthralgia
9. Rash
10. Confusion
11. Insomnia
12. Anorexia
13. Bad taste
14. Headache
15. Photosensitivity.

Contra-indications of Levofloxacin

Hypersensitivity to Levofloxacin and other Fluoroquinolones

Special Precautions while taking Levofloxacin

1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Cerebral arteriosclerosis

Caution while driving the vehicle or operating machine or involved in any hazardous activities. Avoid exposure to sun light

Pregnancy Related Information

Contraindicated.

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated.

Children Related Information

Contraindicated

Indications for Levofloxacin

1.Sinusitis
2.Bronchitis
3.Pneumonia
4.Urinary tract infection
5.Traveler`s diarrhoea
6.Skin and soft tissue infections
7.Urethritis

Interactions for Levofloxacin

N/A

Typical Dosage for Levofloxacin

Adults:
Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
Sinusitis, Bronchitis, Pneumonia, Skin and soft tissue infections: 500 mg daily for 1 - 2 week
Urinary tract infection: 250 mg / day for 10 days
Traveler`s diarrhoea: 500 mg / day along with Loperamide
Urethritis: 500 mg orally once daily for 7 days

Schedule of Levofloxacin

Storage Requirements for Levofloxacin

Store at 25 - 30 degree C in a tightly closed container.

Effects of Missed Dosage of Levofloxacin

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.

Effects of Overdose of Levofloxacin

Give supportive measures and symptomatic treatment. Empty the stomach. Maintain appropriate hydration.

Ambroxol

About Ambroxol

Active N-desmethyl metabolite of bromhexine,systemically active mucolytic agent, Secretomotoric and expectoration improver.

Mechanism of Action of Ambroxol

Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. It decreases mucus viscosity by altering its structure. It depolymerises mucopolysaccharides directly as well as by liberating lysosomal enzymes and by breaking network of fibres in tenacious sputum . It induces thin copious bronchial secretion and possesses antioxidant properties.

Pharmacokinets of Ambroxol

N/A

Onset of Action for Ambroxol

N/A

Duration of Action for Ambroxol

N/A

Half Life of Ambroxol

N/A

Side Effects of Ambroxol

1. Rhinorrhoea
2. Lacrimations
3. Allergic reactions
4. Gastric irritation.

Contra-indications of Ambroxol

Hypersensitivity to the Ambroxol hydrochloride or Bromhexine.

Special Precautions while taking Ambroxol

1.Hepatic impairment
2.Renal impairment
3.Gastric and duodenal ulcer
4.Convulsive disorders

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution

Indications for Ambroxol

1. As Expectorant and mucolytic
2. Conditions associated with production of viscid mucous
3. Bronchitis
4. Pharyngitis
5. Laryngitis
6. Rhinitis
7. Sinusitis
8. Asthmatic bronchitis
9. Mucous bronchiectasis
10. Chronic Pneumonia.

Interactions for Ambroxol

N/A

Typical Dosage for Ambroxol

Oral: 15mg to 30mg three times daily.
Children (6 to 12years): 5ml 2 to 3 times daily
Children (2 to 6years): 2.5ml thrice daily. (5ml liquid contains 30mg Ambroxol hydrochloride)
Children up to 2 years: 7.5mg two times daily

Schedule of Ambroxol

Storage Requirements for Ambroxol

Store in a cool dry place and protect from light. Keep out of reach of children.

Effects of Missed Dosage of Ambroxol

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Ambroxol

Provide symptomatic treatment and supportive measures.

Home Delivery for Levofloxacin + Ambroxol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levofloxacin + ambroxol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levofloxacin + ambroxol and other medicines and health products. Home delivery services for levofloxacin + ambroxol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levofloxacin + ambroxol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levofloxacin + ambroxol before they complete the sale. You can get this information while placing the order for levofloxacin + ambroxol with the pharmacy.

Levofloxacin + Ambroxol is a generic medicine name and there are several brands available for it. Some of the brands for levofloxacin + ambroxol might be better known than levofloxacin + ambroxol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levofloxacin + ambroxol in stock, you can ask for one of the branded alternatives for levofloxacin + ambroxol.