Flupirtine Pharmacology

Flupirtine

About Flupirtine
Aminopyridine derivative,centrally acting nonopioid analgesic.
Mechanism of Action of Flupirtine
Flupirtine maleate is a centrally acting analgesic mainly used to treat pain. It appears to work by suppressing pain perception transmission to the brain and spinal cord. Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Flupirtine does not reduce inflammation or fever. The drug works best for pain associated with noninflammatory conditions. In addition to alleviating pain, flupirtine relaxes muscles through GABA-ergic mechanisms (it inhibits relexes in the spinal cord) and works against seizures. Flupirtine has a low potential for abuse.
Pharmacokinets of Flupirtine
Absorption:Rapidly absorbed after oral absorption
Distribution:Volume of distribution is 154L,plasmaprotein binding 80%
Metabolism:Hepatic
Elimination:Renal
Onset of Action for Flupirtine
N/A
Duration of Action for Flupirtine
N/A
Half Life of Flupirtine
6.5hrs in adults ,10 hrs in elderly
Side Effects of Flupirtine
1.Sedation
2.Dizziness
3.Dry mouth
4.Nausea
5.Headache
6.Heart burn
7.Sweating
8.Vomiting
9.Rare: Liver toxicity and rare cardiac effects
Contra-indications of Flupirtine
1.Established hypersensitivity to flupirtine maleate.
2.Flupirtine should not be given to patients at risk of a hepatic encephalopathy nor to patients. Suffering from cholestasis, since an encephalopathy or ataxia may develop or deteriorate.
3.As flupirtine maleate loosens muscle tenseness patients suffering from myasthenia gravis should not be treated with flupirtine.
4.Since flupirtine maleate is mostly metabolized in the liver, patients with a liver disease and alcohol abusers should not be given Flupirtine.

Special Precautions while taking Flupirtine
1.Do not drive or operate heavy machinery.
2.It is recommended that initial doses of flupirtine be reduced by 50% in patients with even mild degrees of renal impairment.
Pregnancy Related Information
Not recommended
Old Age Related Information
Start with 50% of normal dose ;use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Not recommended <6yrs
Indications for Flupirtine
1.Treatment of acute and chronic pain
2.For painful increased muscle tone of the posture and. Motor muscles
3.Primary headache
4.Tumor pain
5.Dysmenorrheal
6.Pain after traumatologic/ orthopedic operations and injuries.
Interactions for Flupirtine
1.Flupirtine may interact with anticoagulants such as warfarin.
2.Alcohol or other sedatives such as benzodiazepines can increase the tiredness and dizziness that you may experience with flupirtine.
Typical Dosage for Flupirtine
1.100 mg three or four times daily by mouth or 150 mg three or four times daily as a rectal suppository.
2.For children at least 6 years of age, the recommended dose is 50 mg by mouth or 75 mg by rectum three or four times daily to a maximum of 300 mg orally and 450 mg rectally.
3.Use the lowest effective dose for the elderly, patients with kidney or liver impairment, gallbladder disease, or malnourished patients.
4.The duration of treatment should not exceed 4 weeks.
Schedule of Flupirtine
N/A
Storage Requirements for Flupirtine
Store in a cool and dry place protected from light and moisture.
Effects of Missed Dosage of Flupirtine
N/A
Effects of Overdose of Flupirtine
N/A

Home Delivery for Flupirtine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including flupirtine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for flupirtine and other medicines and health products. Home delivery services for flupirtine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take flupirtine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for flupirtine before they complete the sale. You can get this information while placing the order for flupirtine with the pharmacy.

Flupirtine is a generic medicine name and there are several brands available for it. Some of the brands for flupirtine might be better known than flupirtine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have flupirtine in stock, you can ask for one of the branded alternatives for flupirtine.