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- Pharmacology For Cefepime + Tazobactam
Cefepime + Tazobactam Pharmacology
Cefepime + Tazobactam
About Cefepime + TazobactamN/AMechanism of Action of Cefepime + TazobactamN/APharmacokinets of Cefepime + TazobactamN/AOnset of Action for Cefepime + TazobactamN/ADuration of Action for Cefepime + TazobactamN/AHalf Life of Cefepime + TazobactamN/ASide Effects of Cefepime + TazobactamN/AContra-indications of Cefepime + TazobactamN/ASpecial Precautions while taking Cefepime + TazobactamN/APregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Cefepime + Tazobactam1.In the treatment of moderate to severe pneumonia
2.Febrile neutropenic patients empirically
3.Uncomplicated and complicated urinary tract infections
4.Uncomplicated and complicated skin and skin structure infections
5.Complicated intra-abdominal infections.
Interactions for Cefepime + TazobactamN/ATypical Dosage for Cefepime + TazobactamN/ASchedule of Cefepime + TazobactamN/AStorage Requirements for Cefepime + TazobactamN/AEffects of Missed Dosage of Cefepime + TazobactamN/AEffects of Overdose of Cefepime + TazobactamN/ACefepime
About CefepimeFourth Generation cephalosporin antibiotic.Mechanism of Action of CefepimeCefepime is a 3rd generation cephalosporin which exerts its bactericidal action by inhibiting bacterial cell wall synthesis. Cefepime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like CefipimePharmacokinets of CefepimeWell absorbed after Parenteral administration, Distribution: widely distributed, Metabolism: It is metabolized inside the body Excretion: Excreted mainly through urineOnset of Action for Cefepime30 minutesDuration of Action for CefepimeN/AHalf Life of CefepimeN/ASide Effects of Cefepime1.Pain after I.M. injection & thrombophlebitis after I.V. injection.
2 Rashes
3.Vaginitis
4.Pruritus
5.Candiasis
6.Nephrotoxicity
7.Pseudo membranous colitis
8.Nausea
9.Vomiting
10.Elevated liver enzymes
11.Headache
12.Dizziness
13.Hypotention
14.Vertigo
Contra-indications of Cefepime1.Hypersensitivity to cephalosporins or Penicillins
2.Along with other nephrotoxic drugs
Special Precautions while taking Cefepime1.Renal impairment
2.Pseudo membranous colitis
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationContraindicated
Neonates: contraindicatedIndications for Cefepime1.Pneumonia
2.Resistant hospital acquired infections
3.Septicemia,
4.Empiric therapy in febrile neutropenic patients
5.Urinary tract infections
6.Pyelonephritis
7.Tonsillitis, Pharyngitis etc.
8.Skin & soft tissue infections
Interactions for CefepimeN/ATypical Dosage for CefepimeAdults: 1 to 2 gm I.V. twice daily or thrice daily
Urinary tract infections:500mg to 1gm I.V. or I.M. twice daily for 10 days. In severe cases dose may be increased up to 2gm twice daily for 10 days
Infections in neutropenic patients:6gm/day in 3 divided doses; for 1week
Pneumonia:1 to 2 gm twice daily for 10 days
Intra abdominal infections:2gm twice daily for 10 days
Schedule of CefepimeHStorage Requirements for CefepimeStore in a temperature range of 2 degree to 25 degree C and protect from light.Effects of Missed Dosage of CefepimeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefepimeSymptoms of over dosage include neuromuscular disorders and may precipitate seizures. Treatment includes removal of drug from the body by hemodialysis & supportive measuresTazobactam
About TazobactamA Penicillanic acid sulfone beta-lactamase inhibitor, penams, To increase the antibacterial activity of penicillins against ?-lactamase?producing organisms.Mechanism of Action of TazobactamTazobactam is a Penicillanic acid sulfone beta lactamase inhibitor.Sulbactam has no significant antimicrobial activity, despite sharing the ?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Tazobactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against ?-lactamase-secreting resistant bacteria.It is usually given in combination with Piperacillin.Pharmacokinets of TazobactamN/AOnset of Action for TazobactamN/ADuration of Action for TazobactamN/AHalf Life of TazobactamN/ASide Effects of Tazobactam1.Gastrointestinal disturbances
2.Headache
3.Dizziness
4.Insomnia
5.Rash
6.Pain
7.Hypertension
8.Edema
9.Pruritus
10.Agitation
11.Local reactions
Contra-indications of TazobactamHypersensitivity to TazobactamSpecial Precautions while taking Tazobactam1.Renal impairment
2.Cystic fibrosis
3.Haematopoiesis
4.Monitor electrolytes
5.Discontinue if bleeding disorders occur
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Tazobactam1.Skin infections
2.Pneumonia
3.Postpartum endometritis
4.Pelvic inflammatory disease
5.Appendicitis
6.Peritonitis
Interactions for TazobactamN/ATypical Dosage for TazobactamIV Infusion over 30 minutes.
Adults: 3 to 4 grams of Piperacillin, in combination with 0.375 to 0.5 grams of Tazobactam, every 6 - 8 hours for 7 - 10 days.
Schedule of TazobactamN/AStorage Requirements for TazobactamN/AEffects of Missed Dosage of TazobactamN/AEffects of Overdose of TazobactamN/AHome Delivery for Cefepime + Tazobactam in Your City
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