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- Pharmacology For Telmisartan + Indapamide
Telmisartan + Indapamide Pharmacology
Telmisartan + Indapamide
About Telmisartan + IndapamideN/AMechanism of Action of Telmisartan + IndapamideN/APharmacokinets of Telmisartan + IndapamideN/AOnset of Action for Telmisartan + IndapamideN/ADuration of Action for Telmisartan + IndapamideN/AHalf Life of Telmisartan + IndapamideN/ASide Effects of Telmisartan + IndapamideN/AContra-indications of Telmisartan + IndapamideN/ASpecial Precautions while taking Telmisartan + IndapamideN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Telmisartan + IndapamideHypertension.Interactions for Telmisartan + IndapamideN/ATypical Dosage for Telmisartan + IndapamideN/ASchedule of Telmisartan + IndapamideN/AStorage Requirements for Telmisartan + IndapamideN/AEffects of Missed Dosage of Telmisartan + IndapamideN/AEffects of Overdose of Telmisartan + IndapamideN/ATelmisartan
About TelmisartanAngiotensin II Receptor antagonist, Antihypertensive.Mechanism of Action of TelmisartanIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of TelmisartanAbsorption: Absorbed orally, bioavailability is about 42% Distribution: It is distributed in to the body in a highly protein bound form, Metabolism: Metabolized by glucuronide conjugation in to an inactive metabolite. Excretion: Excreted mainly through faeces and rest is excreted through urine.Onset of Action for TelmisartanN/ADuration of Action for Telmisartan24 hoursHalf Life of Telmisartan24 hoursSide Effects of Telmisartan1.Dizziness
2.Headache
3.Coughing
4.Edema
5.Nausea
6.Abdominal pain
7.Diarrhoea
8.Dyspepsia
9.Pharyngitis
10.Sinusitis
11.Upper respiratory tract infections
12.Urinary tract infections
13.Elevated liver enzymes
14.Weakness
15.Chest pain
16.Myalgia
17.Back pain
18.Neutropenia
19.Fetopathic
20.Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
21.Urticaria
22.Rashes
23.Hyperkalemia
Contra-indications of TelmisartanHypersensitivity to the drugSpecial Precautions while taking Telmisartan1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Aortic or mitral valve stenosis
5.Obstructive cardiomyopathy
6.Use cautiously in volume depleted and salt depleted individuals, these conditions should be corrected before starting the therapy
7.Patient should be cautiously involve in driving or operating heavy machinery during therapy
8.Avoid alcohol or use with caution during therapy
9.Use with caution in hyperkalemia and along with potassium sparing diuretics
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Telmisartan1.HypertensionInteractions for TelmisartanN/ATypical Dosage for Telmisartan40mg once daily
Maintenance dose: 20 to 80mg once daily
Schedule of TelmisartanHStorage Requirements for TelmisartanStore at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container. Do not remove blisters until just before taking tablets
Effects of Missed Dosage of TelmisartanTake the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular doseEffects of Overdose of TelmisartanTreatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal salineIndapamide
About IndapamideThiazide-related(a non-thiazide sulphonamide) drug, Diuretic, Antihypertensive.Mechanism of Action of IndapamideIt exerts thiazides like diuretic action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion.
It causes vasodilatation by Ca channel blockade. It decreases total peripheral resistance and exerts anti hypertensive action. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.
Pharmacokinets of IndapamideAbsorption: It is compleately absorbed orally.
Distribution: Widely distributed
Metabolism: Extensively metabolized inside the body, and a small portion reaches tubular fluid.
Excretion: Excreted mainly through urine and rest is excreted through faeces.
Onset of Action for Indapamide1 to 2 hoursDuration of Action for Indapamide24 to 36 hoursHalf Life of IndapamideN/ASide Effects of Indapamide1. Dizziness
2 Headache
3. Orthostatic hypotension
4. Back pain
5. Infection
6. Rhinitis
7. Pharyngitis
8. Sinusitis
9. Vertigo
10 Nausea
11. Diarrhoea
12. Vomiting
13. Constipation
14. Muscle cramps
15. Peripheral edema
16. Polyuria
17. Weakness
18. Hypochloremia
19. Hypokalaemia
20. Hyponatraemia
21. Hyper urecaemia
22. Elevated levels of glucose calcium and lipids
23. Gastro intestinal disturbances
24. Impotence
25. Visual impairment
26. Electrolyte imbalance
27.Ototoxicity
Contra-indications of Indapamide1. Hepatic impairment.
2. Hypersensitivity to the drug
3. Hypersensitivity to Sulfonamides
4. Anuric renal failure
5. Cerebro vascular accidents
Special Precautions while taking Indapamide1. Renal impairment
2. Progressive Liver diseases
3. Hyper urecaemia and Gout
4. Diabetes mellitus
5. Fluid and electrolyte imbalance
6. Cirrhosis
7. Hyper calcaemia
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Indapamide1. Hypertension
2. Oedema
Interactions for IndapamideDiazoxide: Synergistic action - may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretic induced hypokalaemia may precipitate digitalis toxicity.
Frusemide: Synergy leading to profound diuresis and greater than predicted electroyte loss.
Sulfonylureas: Hypoglycaemic effects enhanced.
Chlorpropamide: Hypokalaemia.
Propantheline: Bioavailability of indapamide increased.
Metoclopramide: Bioavailability of indapamide decreased.
NSAID`s: Natriuretic effect of indapamide decreased. Typical Dosage for IndapamideHyper tension: 1.25mg single daily dose. Increased to 2.5mg if required after 4 weeks.
Maximum dose: 5mg/day
Edema: 2.5mg single daily dose. Increased to 5mg if required after 1 week.
Schedule of IndapamideGStorage Requirements for IndapamideStore at a cool dry place; and at a temperature below 30 degree C. in a well closed container. Keep out of reach of children.Effects of Missed Dosage of IndapamideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Indapamide Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and assist respiratory, cardiovascular, and renal function as indicated. Monitor and support fluid and electrolyte balance.Home Delivery for Telmisartan + Indapamide in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for telmisartan + indapamide and other medicines and health products. Home delivery services for telmisartan + indapamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
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Telmisartan + Indapamide is a generic medicine name and there are several brands available for it. Some of the brands for telmisartan + indapamide might be better known than telmisartan + indapamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have telmisartan + indapamide in stock, you can ask for one of the branded alternatives for telmisartan + indapamide.